Saturday, October 8, 2016

Lupus viral triggers ?

Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target cell type triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.

(Previously fungal infections were suggested as the large outer infections for lupus, discord lupus, and SJ)


Late onset SLE and SJ : enteroviruses or Paramoxyoviruses

HLA-DR3 (anti RO) (HLA-DR cytosolic enveloped RNA)

coxsackie in SJ glands
http://onlinelibrary.wiley.com/store/10.1002/art.20463/asset/20463_ftp.pdf?v=1&t=iu1azvgw&s=075c4fdaeaaf4f1af4e7327a5769719de8c38ae1

coxsackie cross-reactivity of 2B protein and RO
https://www.ncbi.nlm.nih.gov/pubmed/15958081

Enterovirus and SLE
https://www.ncbi.nlm.nih.gov/pubmed/25488421

SLE and graves
http://file.scirp.org/pdf/OJIM_2015030313432940.pdf

enterovirus and graves disease
https://www.ncbi.nlm.nih.gov/pubmed/23280563

MG, thymus and enterovirus
https://www.ncbi.nlm.nih.gov/pubmed/20368632

SLE and MG
https://www.ncbi.nlm.nih.gov/pubmed/22160434

Enteroviruses and Nicotine Acetylcholine receptors (coxsackie family viruses)
http://angelabiggs.blogspot.com/2016/08/enteroviruses-and-nicotine.html

Paramoxyoviridae and Muscarine Acetylcholoine receptors (measles family viruses)
http://angelabiggs.blogspot.com/2016/09/do-paramyxoviridae-measles-family.html

Paramoxyovirus and Lupus
https://www.ncbi.nlm.nih.gov/pubmed/4115878
https://www.ncbi.nlm.nih.gov/pubmed/5444077

SJ and antibodies to M3R
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990929/
http://www.ncbi.nlm.nih.gov/pubmed/23629427
http://www.ncbi.nlm.nih.gov/pubmed/23135882


Juvenile onset lupus : Hepatitis C (flavivirus)

HLA-DRB1and HLA-DR5 (no anti-RO) (HLA-DR cytosolic enveloped RNA)

HLA-DR5 and Hepatitis C (retrovirus)
https://www.ncbi.nlm.nih.gov/pubmed/7993158

lupus and liver
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194618/
http://www.omicsonline.org/open-access/liver-complications-associated-with-systemic-lupus-erythematosus-2161-1149-1000146.php?aid=40992

SLE and Hepatitis C: only in the group with no  anti-dsDNA antibodies,
https://www.ncbi.nlm.nih.gov/pubmed/11145039


Discord lupus : Herpes or HPV ?

HLA-A, HLA-B (HLA-A nuclear DNA virus, HLA-B mitochodrial DNA virus)

http://onlinelibrary.wiley.com/store/10.1002/art.1780230804/asset/1780230804_ftp.pdf?v=1&t=iu1dgvk1&s=869fb790e54ba0422bd6f2f640b5b6e5c9a4f349

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.1977.tb12535.x/abstract

discord lupus at site of healed herpes zoster
https://www.researchgate.net/publication/277893675_Discoid_Lupus_Erythematosus_at_the_Site_of_Healed_Herpes_zoster_Wolf's_Isotopic_Response_Case_Report

is this the HHV8 group? or are they systemic lupus? or is this an early onset systemic lupus?

HHV8 and lupus
https://www.researchgate.net/publication/258957164_High_seroprevalence_of_human_herpesvirus_8_infection_in_patients_with_systemic_lupus_erythematosus

EBV and discord lupus
https://www.hindawi.com/journals/jir/2012/370516/
https://scholarsarchive.byu.edu/etd/6592/
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2006.01819.x/full


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