Sunday, October 9, 2016

Vitamin D receptor and polyomaviruses?

This blog post is just notes right now. Do polyomaviruses use vit D receptors to get to the ER? 

Alopecia and HLA-C (mailbox for the ER)
https://www.ncbi.nlm.nih.gov/pubmed/23588886

(there are other forms of alopecia we are looking at this HLA-C group)

Multiple sclerosis and HLA-C (not the MS triggered by zoster using HLA-B)
https://www.ncbi.nlm.nih.gov/pubmed/21067287

Polyomaviruses infect the endoplasmic reticulum (BK JC viruses)
https://www.ncbi.nlm.nih.gov/pubmed/20373089
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754070/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563856/

the docking sites for the VDR receptor at the cytosol are on the endoplasmic reticulum (using fluorescent bp-calcitriol)

https://books.google.com/books?id=sv4xBwAAQBAJ&pg=PA135&lpg=PA135&dq=endoplasmic+reticulum+calcitriol&source=bl&ots=c1RAYpgYS1&sig=39WUGn5TCOkHmPOgOd9UY3mi_JY&hl=en&sa=X&ved=0ahUKEwib5KX01tnSAhUC9GMKHSOSAYUQ6AEIKTAE#v=onepage&q=endoplasmic%20reticulum%20calcitriol&f=false

vit D receptor
https://en.wikipedia.org/wiki/Calcitriol_receptor

"calcitriol receptor, also known as the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors.[3] " from wiki

vit D receptor plays a role in Hair loss
https://www.ncbi.nlm.nih.gov/pubmed/27151518
https://www.ncbi.nlm.nih.gov/pubmed/21693169

Vit D and the ER
https://www.ncbi.nlm.nih.gov/pubmed/23012375

The VDR receptor aka vit D receptor located at the plasma membrane and the endoplasmic reticulum
https://www.ncbi.nlm.nih.gov/pubmed/8756529

Polyomaviruses and alopecia
https://www.ncbi.nlm.nih.gov/pubmed/25348766
https://www.ncbi.nlm.nih.gov/pubmed/23593936

Is there an overlap of MS and alopecia? if they are both triggered by a polyomavirus there might be

the VDR (vit D receptor) gene increased the risk specifically for progressive multiple sclerosis
https://www.ncbi.nlm.nih.gov/pubmed/16076630

MS triggered by hepatitis B vaccine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266455/

Alopecia triggered by hepatitis B vaccine? it is a controversy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956183/

(note there is more than one type of MS)

Looking at boards:

Alopecia and MS?
I've had Alopecia universalis since I was 12 (I'm nearly 30 now) so since I was young I have not had a single hair on my head or body. I lost all my eyebrows, eyelashes ... Everything! Although a big shock at first, I am now totally comfortable with my Alopecia and I understand that my immune system attacks my hair follicles, not allowing me to grow any hair.
The strange thing I've found is over the past 8-12 months I have started growing hair! I've not had a single hair on my head or body in over 18 years and now all of a sudden I have eyebrows, eyelashes, under arm hair (not liking this lol) and a little hair on my head.
Do you think it's possible that if my problems are due to MS and I have had a relapse, that maybe my immune system has been drawn to attacking another part of my body (for example my brain!) and so my hair follicles have been given a break for a while?
Sorry if this sounds stupid! It's just you don't know how weird it is for my to suddenly be growing hair after all these years .
Would love to hear people's thoughts on this :)





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