HLA location hypothesis and the linked viruses

HLA are the mailboxes for T cells showing the viral infection inside. Could these HLAs match up with these viruses?  These are guesses.

HLA A (Nucleus mailbox)DNA virus

A1, A10   beta-herpes family viruses (CMV)

A9  gamma-herpes family viruses (EBV)

 HPV viruses

HLA B (mitochondrial mailbox) DNA Virus

B alpha-herpes family viruses (Zoster, HSV1, HSV2)

*see notes at bottom

HLA C (endoplasmic reticulum mailbox) RNA or DNA virus? 

"the majority of the HLA-C4 molecules are not transported, but are retained in the endoplasmic reticulum"
https://www.ncbi.nlm.nih.gov/pubmed/9551969

Polyomaviruses infect the endoplasmic reticulum (BK JC viruses)
https://www.ncbi.nlm.nih.gov/pubmed/20373089

Hepatitis B

note that these are DNA viruses that look like they use the vit D receptor which goes through the ER
then into the nucleus

HLA DR (cytosol mailbox) enveloped RNA virus

DR1/ DR4 H5N1 flu

DR2 / DR4 H1N1 flu

DR3 / DR7  Enteroviruses and paramyxoviruses

DR5 / DR6 Retroviruses (HIV HTLV)

DR15 / DRA Flaviviruses (west nile zika dengue yellow fever hepC )


HLA DQ (cytosol mailbox) NON-enveloped RNA virus

HLA-DQ astroviruses (celiac disease)/ reoviruses

https://www.ncbi.nlm.nih.gov/pubmed/20573860
http://www.drugpapers.com/paper/9864029/company-detail.html

HLA E (vesicle mailbox) ????

majority of HLA-E are found on vesicles to lysosomes
https://www.ncbi.nlm.nih.gov/pubmed/26310830


*Notes: HLA-B has a strong association to the mitochondria. Abacavir a viral drug and Flucoxacillin a type of penicillin both of which can cause mitochondrial toxicity are HLA-B sensitive.   I have HLA-B here connected to the  alpha-herpes family which could be using the beta-estrogen receptor which cycles to the mitochondria allowing the virus to hide.

some HPV locates to the mitochondria
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075625
HLA-B and HPV
https://www.ncbi.nlm.nih.gov/pubmed/16206270

HPV has been linked to cancer so some viral HPV must be going to the nucleus using other Cannabinoid receptors

HPV uses cannabinoid receptors and CBR1 locates to the mitochondria.
https://www.ncbi.nlm.nih.gov/pubmed/25195527