Autoimmune cross-targeting hypothesis: the layering of 2 different infections on one target cell type triggers autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.
Previous post linking parkinson's to mycobacteria as the large infection ( the alpha-synuclein is linked to mycobacteria on the bottom of this page)
This post is looking at the viral suspects in parkinson's disease. These are hypotheses not proven.
Idopathic Parkinson's and melanocortin receptors: Flaviviruses ?
Parkinson's and the melanocortin receptor (MCR1)
http://www.mdsabstracts.com/abstract.asp?MeetingID=801&id=111124
note that odor and melanocortin receptors are linked
odor and idopathic parkinson's
https://www.omicsonline.org/open-access/odor-identification-function-differs-between-vascular-parkinson-ismand-akinetictype-parkinsons-disease-2161-0460-1000207.php?aid=68146
Late onset sporadic parkinson's with HLA-DR (cytosol mailbox RNA)
https://www.ncbi.nlm.nih.gov/pubmed/22807207
https://www.ncbi.nlm.nih.gov/pubmed/23139797
https://www.ncbi.nlm.nih.gov/pubmed/27073595
Parkinson's drug works on West nile virus inhibiting it's replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/
Hepatitis C and parkinson's
https://www.ncbi.nlm.nih.gov/pubmed/25608223
http://www.medscape.com/viewarticle/852066
http://www.neurology.org/content/86/9/840
west nile
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939474/
What are the other types of parkinson's
Parkinson's and other HLAs? : HLA- A, B, C, and D...a virus in every area?
https://www.researchgate.net/publication/16255474_Histocompatibility_types_in_Parkinson's_disease
Vascular parkinson's : flu : HLA-D and HLA-B14
Post-encephalitic Parkinsonism
arteriosclerotic parkinsonism aka vascular parkinson's?
https://www.ncbi.nlm.nih.gov/pubmed/22121251
http://ageing.oxfordjournals.org/content/34/2/97.full.pdf
Postencephalitic parkinson's and the flu
https://en.wikipedia.org/wiki/Postencephalitic_parkinsonism
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(82)90820-0/abstract
H1N1 and vascular thrombosis
http://cid.oxfordjournals.org/content/52/2/e14.full
frontal lobe syndrome with flu
https://www.ncbi.nlm.nih.gov/pubmed/10788752
Vascular parkinson's is not responsive to l-dopa?
https://www.ncbi.nlm.nih.gov/pubmed/15713855
http://jnnp.bmj.com/content/75/4/545.full.pdf
"awakenings" they were responsive to L-dopa?
Postencephalitic parkinson's and the flu
https://en.wikipedia.org/wiki/Postencephalitic_parkinsonism
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(82)90820-0/abstract
Vascular parkinson's and tiny strokes
https://www.michaeljfox.org/foundation/news-detail.php?could-silent-strokes-cause-parkinson-disease
the flu and cardiovascular disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387426/
Influenza A protein moves into the mitochondria
https://www.ncbi.nlm.nih.gov/pubmed/25140902
Is this protein what is being seen in the HLA-B14 mitochondria mailbox?
rare because this flu does not come around often?
Parkinsonism with dementia/alzheimer's : herpes viruses (HLA- A, B)
EBV and parkinson's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1763051/
https://www.ncbi.nlm.nih.gov/pubmed/21519006
Sarciodosis looks like parkinson's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027760/
Herpes zoster and sarciodosis
https://www.ncbi.nlm.nih.gov/pubmed/24616865
EBV and HHV6 and sarciodosis
https://www.ncbi.nlm.nih.gov/pubmed/24908953
Stroke caused by zoster
http://www.uptodate.com/contents/stroke-caused-by-varicella-zoster-virus
Common type with aging? overlaps with bipolar and schizophrenia
Drug induced parkinsonism?
the drug goes to the mitochondria
HLA-B (mitochondrial mailbox)
https://www.ncbi.nlm.nih.gov/pubmed/2567491
The larger Mycobacteria infection of parkinson's (copied from earlier post)
Parkinson's had alpha-synuclein in their gut (a different type of lewy body) as well as in the brain
http://www.livescience.com/36354-parkinsons-disease-colonoscopy-diagnosis.html
alpha-synuclein has also been found in the blood of type 2 diabetes
http://www.nature.com/articles/srep12081
alpha-synuclein is also found in multiple sclerosis which could involve mycobacterias
http://www.ncbi.nlm.nih.gov/pubmed/19151622
cGMP increases the amount of alpha-synuclein
http://eurekamag.com/research/034/334/034334017.php
cGMP and synuclein (functional connections)
https://www.ncbi.nlm.nih.gov/pubmed/18064424
https://www.ncbi.nlm.nih.gov/pubmed/17610578
Parkinson's, type 2 diabetes, fatty acid liver disease, crohn's, and psoriasis were previously connected to Mycobacterias on this blog. The quorum of mycobacteria is cGMP. (which on a previous blog post was connected to type 2 diabetes and fatty liver disease)
Thus the alpha-synuclein seen in these cases could be caused by the high concentraiton of cGMP made by mycobacterias as they attempt to talk to each other?
Why would psoriasis and crohn's not have synuclein until parkinson's developed? is alpha synclein caused by these specific viruses? by the autoimmune state of nerves?
or is it generated by the viruses that alter glutamate release?
Previous post linking parkinson's to mycobacteria as the large infection ( the alpha-synuclein is linked to mycobacteria on the bottom of this page)
This post is looking at the viral suspects in parkinson's disease. These are hypotheses not proven.
Idopathic Parkinson's and melanocortin receptors: Flaviviruses ?
Parkinson's and the melanocortin receptor (MCR1)
http://www.mdsabstracts.com/abstract.asp?MeetingID=801&id=111124
note that odor and melanocortin receptors are linked
odor and idopathic parkinson's
https://www.omicsonline.org/open-access/odor-identification-function-differs-between-vascular-parkinson-ismand-akinetictype-parkinsons-disease-2161-0460-1000207.php?aid=68146
Late onset sporadic parkinson's with HLA-DR (cytosol mailbox RNA)
https://www.ncbi.nlm.nih.gov/pubmed/22807207
https://www.ncbi.nlm.nih.gov/pubmed/23139797
https://www.ncbi.nlm.nih.gov/pubmed/27073595
Parkinson's drug works on West nile virus inhibiting it's replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/
Hepatitis C and parkinson's
https://www.ncbi.nlm.nih.gov/pubmed/25608223
http://www.medscape.com/viewarticle/852066
http://www.neurology.org/content/86/9/840
west nile
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939474/
What are the other types of parkinson's
Parkinson's and other HLAs? : HLA- A, B, C, and D...a virus in every area?
https://www.researchgate.net/publication/16255474_Histocompatibility_types_in_Parkinson's_disease
Post-encephalitic Parkinsonism
arteriosclerotic parkinsonism aka vascular parkinson's?
https://www.ncbi.nlm.nih.gov/pubmed/22121251
http://ageing.oxfordjournals.org/content/34/2/97.full.pdf
Postencephalitic parkinson's and the flu
https://en.wikipedia.org/wiki/Postencephalitic_parkinsonism
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(82)90820-0/abstract
H1N1 and vascular thrombosis
http://cid.oxfordjournals.org/content/52/2/e14.full
frontal lobe syndrome with flu
https://www.ncbi.nlm.nih.gov/pubmed/10788752
Vascular parkinson's is not responsive to l-dopa?
https://www.ncbi.nlm.nih.gov/pubmed/15713855
http://jnnp.bmj.com/content/75/4/545.full.pdf
"awakenings" they were responsive to L-dopa?
Postencephalitic parkinson's and the flu
https://en.wikipedia.org/wiki/Postencephalitic_parkinsonism
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(82)90820-0/abstract
Vascular parkinson's and tiny strokes
https://www.michaeljfox.org/foundation/news-detail.php?could-silent-strokes-cause-parkinson-disease
the flu and cardiovascular disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387426/
HLA-B14 antigen and postencephalitic parkinson's disease
https://www.ncbi.nlm.nih.gov/pubmed/7417054https://www.ncbi.nlm.nih.gov/pubmed/25140902
Is this protein what is being seen in the HLA-B14 mitochondria mailbox?
rare because this flu does not come around often?
Parkinsonism with dementia/alzheimer's : herpes viruses (HLA- A, B)
EBV and parkinson's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1763051/
https://www.ncbi.nlm.nih.gov/pubmed/21519006
Sarciodosis looks like parkinson's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027760/
Herpes zoster and sarciodosis
https://www.ncbi.nlm.nih.gov/pubmed/24616865
EBV and HHV6 and sarciodosis
https://www.ncbi.nlm.nih.gov/pubmed/24908953
Stroke caused by zoster
http://www.uptodate.com/contents/stroke-caused-by-varicella-zoster-virus
Common type with aging? overlaps with bipolar and schizophrenia
Drug induced parkinsonism?
the drug goes to the mitochondria
HLA-B (mitochondrial mailbox)
https://www.ncbi.nlm.nih.gov/pubmed/2567491
The larger Mycobacteria infection of parkinson's (copied from earlier post)
Parkinson's had alpha-synuclein in their gut (a different type of lewy body) as well as in the brain
http://www.livescience.com/36354-parkinsons-disease-colonoscopy-diagnosis.html
alpha-synuclein has also been found in the blood of type 2 diabetes
http://www.nature.com/articles/srep12081
alpha-synuclein is also found in multiple sclerosis which could involve mycobacterias
http://www.ncbi.nlm.nih.gov/pubmed/19151622
cGMP increases the amount of alpha-synuclein
http://eurekamag.com/research/034/334/034334017.php
cGMP and synuclein (functional connections)
https://www.ncbi.nlm.nih.gov/pubmed/18064424
https://www.ncbi.nlm.nih.gov/pubmed/17610578
Parkinson's, type 2 diabetes, fatty acid liver disease, crohn's, and psoriasis were previously connected to Mycobacterias on this blog. The quorum of mycobacteria is cGMP. (which on a previous blog post was connected to type 2 diabetes and fatty liver disease)
Thus the alpha-synuclein seen in these cases could be caused by the high concentraiton of cGMP made by mycobacterias as they attempt to talk to each other?
Why would psoriasis and crohn's not have synuclein until parkinson's developed? is alpha synclein caused by these specific viruses? by the autoimmune state of nerves?
or is it generated by the viruses that alter glutamate release?
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