Sunday, October 9, 2016

Parkinson's disease, HLAs, and viruses

Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target cell type triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.

Previous post linking parkinson's to mycobacteria as the large infection ( the alpha-synuclein is linked to mycobacteria on the bottom of this page)

This post is looking at the viral suspects in parkinson's disease. These are hypotheses not proven.

Idopathic Parkinson's and melanocortin receptors: Flaviviruses ?

Parkinson's and the melanocortin receptor (MCR1)
http://www.mdsabstracts.com/abstract.asp?MeetingID=801&id=111124

note that odor and melanocortin receptors are linked

odor and idopathic parkinson's
https://www.omicsonline.org/open-access/odor-identification-function-differs-between-vascular-parkinson-ismand-akinetictype-parkinsons-disease-2161-0460-1000207.php?aid=68146

Late onset sporadic parkinson's with HLA-DR (cytosol mailbox RNA)
https://www.ncbi.nlm.nih.gov/pubmed/22807207
https://www.ncbi.nlm.nih.gov/pubmed/23139797
https://www.ncbi.nlm.nih.gov/pubmed/27073595

Parkinson's drug works on West nile virus inhibiting it's replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/

Hepatitis C and parkinson's
https://www.ncbi.nlm.nih.gov/pubmed/25608223
http://www.medscape.com/viewarticle/852066
http://www.neurology.org/content/86/9/840

west nile
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939474/

What are the other types of parkinson's

Parkinson's and other HLAs? : HLA- A, B, C, and D...a virus in every area?
https://www.researchgate.net/publication/16255474_Histocompatibility_types_in_Parkinson's_disease

Vascular parkinson's  : flu : HLA-D and HLA-B14
Post-encephalitic Parkinsonism

arteriosclerotic parkinsonism aka vascular parkinson's?
https://www.ncbi.nlm.nih.gov/pubmed/22121251
http://ageing.oxfordjournals.org/content/34/2/97.full.pdf

Postencephalitic parkinson's and the flu
https://en.wikipedia.org/wiki/Postencephalitic_parkinsonism
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(82)90820-0/abstract

H1N1 and vascular thrombosis
http://cid.oxfordjournals.org/content/52/2/e14.full

frontal lobe syndrome with flu
https://www.ncbi.nlm.nih.gov/pubmed/10788752

Vascular parkinson's is not responsive to l-dopa?
https://www.ncbi.nlm.nih.gov/pubmed/15713855
http://jnnp.bmj.com/content/75/4/545.full.pdf

"awakenings" they were responsive to L-dopa?

Postencephalitic parkinson's and the flu
https://en.wikipedia.org/wiki/Postencephalitic_parkinsonism
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(82)90820-0/abstract

Vascular parkinson's and tiny strokes
https://www.michaeljfox.org/foundation/news-detail.php?could-silent-strokes-cause-parkinson-disease

the flu and cardiovascular disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387426/

HLA-B14 antigen and postencephalitic parkinson's disease
https://www.ncbi.nlm.nih.gov/pubmed/7417054

Influenza A protein moves into the mitochondria
https://www.ncbi.nlm.nih.gov/pubmed/25140902

Is this protein what is being seen in the HLA-B14 mitochondria mailbox?

rare because this flu does not come around often?


Parkinsonism with dementia/alzheimer's : herpes viruses (HLA- A, B)

EBV and parkinson's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1763051/
https://www.ncbi.nlm.nih.gov/pubmed/21519006

Sarciodosis looks like parkinson's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027760/

Herpes zoster and sarciodosis
https://www.ncbi.nlm.nih.gov/pubmed/24616865

EBV and HHV6 and sarciodosis
https://www.ncbi.nlm.nih.gov/pubmed/24908953

Stroke caused by zoster
http://www.uptodate.com/contents/stroke-caused-by-varicella-zoster-virus

Common type with aging? overlaps with bipolar and schizophrenia


Drug induced parkinsonism?

the drug goes to the mitochondria

HLA-B (mitochondrial mailbox)
https://www.ncbi.nlm.nih.gov/pubmed/2567491


The larger Mycobacteria infection of parkinson's (copied from earlier post)

Parkinson's had alpha-synuclein in their gut (a different type of lewy body) as well as in the brain
http://www.livescience.com/36354-parkinsons-disease-colonoscopy-diagnosis.html

alpha-synuclein has also been found in the blood of type 2 diabetes
http://www.nature.com/articles/srep12081

alpha-synuclein is also found in multiple sclerosis which could involve mycobacterias
http://www.ncbi.nlm.nih.gov/pubmed/19151622

cGMP increases the amount of alpha-synuclein
http://eurekamag.com/research/034/334/034334017.php

cGMP and synuclein (functional connections)
https://www.ncbi.nlm.nih.gov/pubmed/18064424
https://www.ncbi.nlm.nih.gov/pubmed/17610578

Parkinson's, type 2 diabetes, fatty acid liver disease, crohn's, and psoriasis were previously connected to Mycobacterias on this blog.  The quorum of mycobacteria is cGMP. (which on  a previous blog post was connected to type 2 diabetes and fatty liver disease)

Thus the alpha-synuclein seen in these cases could be caused by the high concentraiton of cGMP made by mycobacterias as they attempt to talk to each other?

Why would psoriasis and crohn's not have synuclein until parkinson's developed? is alpha synclein caused by these specific viruses? by the autoimmune state of nerves?

 or is it generated by the viruses that alter glutamate release?

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