Multiple sclerosis, viral triggers, and HLAs ?

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

In MS the nerves are the target. Mycobacteria as the large infection and there are several possible viral triggers.

HLA-B: Herpes-alpha (zoster): Relapsing remitting
HLA-C: Polyomavirus (hepatitis B) : primary progressive
HLA-DR15 : Flavivirus (hepatitis C) :Secondary progressive
HLA-A: Herpes-gamma (epstein barr): progressive relapsing


(note that HLA-DR1 seems connected to a secreted bacterial/mycobacterial protein and this hasn't been figured out yet)

Two types of MS based on HLA: 291 were HLA-A/B  and 97 were HLA-D (and HLA-c?)
https://www.ncbi.nlm.nih.gov/pubmed/6978384

Specifically the HLA-DRA and HLA-C is a group
https://www.ncbi.nlm.nih.gov/pubmed/21067287

MS Relapsing remitting :

HLA-B Herpes alpha group which uses the Beta estrogen receptors which cycle to the mitochondria

woman are more likely to have relapsing remitting multiple sclerosis perhaps because of the changing estrogen levels which can release the herpes zoster from the mitochondria.

Herpes zoster and MS
http://jid.oxfordjournals.org/content/204/2/177.full
https://www.ncbi.nlm.nih.gov/pubmed/24635924
https://www.ncbi.nlm.nih.gov/pubmed/18306233

MS primary progressive

HLA-C

Endoplasmic reticulum viruses are known to be polyomaviruses

Hepatitis B and MS
https://www.ncbi.nlm.nih.gov/pubmed/27699497
https://www.ncbi.nlm.nih.gov/pubmed/11172163 (the vaccine worry)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266455/
were the ones who reacted to the vaccine the ones with mycobacterial infections?

Is there is a relationship between hepatitis B and vitamin D?
http://www.hoajonline.com/internalmedicine/2052-6954/1/2


Mycobacteria as the large infection

mycobacteria and Epstein barr virus (HLA-A)  in multiple sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/26956729
http://www.ncbi.nlm.nih.gov/pubmed/26453465

Psoriasis has been connected to MS
http://www.ncbi.nlm.nih.gov/pubmed/26352056
http://www.ncbi.nlm.nih.gov/pubmed/27125193
http://www.ncbi.nlm.nih.gov/pubmed/19924503

psoriasis mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/24050284
http://www.ncbi.nlm.nih.gov/pubmed/18485527

mycobacteria infect schwann cells which produce myelin
http://www.ncbi.nlm.nih.gov/pubmed/20739294
http://www.ncbi.nlm.nih.gov/pubmed/15019586