Matching autoimmune diseases, HLAs, and viruses

Autoimmune cross-targeting hypothesis:

The layering of 2 different infections on one target cell type triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, or spirochete infection marking the outside.

HLA Location hypothesis:

The HLA which is the T-cell mailbox reflects what area of the cell has an infection.

HLA-A the nucleus
HLA-B the mitochondria
HLA-C the endoplasmic reticulum
HLA-DR the cytosol encapsulated virus
HLA-DQ the cytosol non encapsulated virus
HLA-DP plasma membrane of immune cells (APC)

This post is just looking at the viral suspects for each autoimmune disease and seeing if the HLAs match.

Type 1 Diabetes HLA-DR3 and DR4
https://www.ncbi.nlm.nih.gov/pubmed/3527834

Enteroviruses:  HLA-DR3 (coxsackie)
Influenza: HLA-DR4

Hashimoto's and Graves HLA-DR5 and HLA-DR3

Retroviruses HLA-DR5 / DR6 (HIV HTLV) (hepatitis B also?)
Enteroviruses:  HLA-DR3 (coxsackie)

Hashimoto's , graves, and viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654877/

Myasthenia Gravis HLA-DR3, HLA-DR15

Enteroviruses HLA-DR3
Flaviviruses HLA-DR15

HLA-DR3, early onset MG, and acetylcholine
http://www.jimmunol.org/content/167/2/1118.full

Late onset MG and HLA-DR15
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348874/

Narcolepsy HLA-DR2 and HLA-DQ1

Influenza HLA-DR2
Reovirus HLA-DQ1

narcolepsy and flu (H1N1)
https://www.ncbi.nlm.nih.gov/pubmed/26668381

Pots syndrome (reovirus???) and narcolepsy
http://journal.frontiersin.org/article/10.3389/fneur.2014.00118/full

Multiple sclerosis Two types of MS : HLA-A/B  and  HLA-D/C

Herpes-alpha (zoster family)  HLA-B
Polyomavirus (hepatitis B) HLA-C

http://angelabiggs.blogspot.com/2016/10/multiple-sclerosis-viral-triggers-and.html

Schizophrenia : HLA-A/B

The 3 types of schizophrenia match up with the 3 types of herpes viruses
http://angelabiggs.blogspot.com/2016/09/schizophrenia-and-autoimmune-cross.html

Herpes beta, herpes gamma  HLA-A
https://kclpure.kcl.ac.uk/portal/en/publications/schizophrenia-and-hla-a-review(46aae44a-139d-4e0f-8162-a1ecbab7300b).html

Herpes-alpha HLA-B
https://www.ncbi.nlm.nih.gov/pubmed/16960807

Parkinson's

Late onset sporadic parkinson's : flaviviruses or flu : HLA-DR (Flu HLA-DR4)
Parkinsonism with dementia/alzheimer's : herpes viruses HLA- A, B

H5N1 flu parkinsons
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=500


http://angelabiggs.blogspot.com/2016/10/parkinsons-disease-and-viruses-this.html

Lupus 

Enteroviruses: HLA-DR3 (anti RO)
Retrovirus/ Hepatitis B  : HLA-DRB1and HLA-DR5 (no anti-RO)

Discord lupus

Herpes: HLA-A/B

Guillian Barre

Flavivirus : HLA-DR33
Herpes Zoster: HLA-B15

Acute Flaccid Paralysis

Enterovirus: HLA-DR3

https://www.ncbi.nlm.nih.gov/pubmed/12721936

Fisher Syndrome

Flu: HLA-DR2

Autism (3 types)

Flu HLA-DR4  (flu and RA:  frontal lobe autism) (HLA-DRB1.4)

MMR HLA-DRB1.13 (Measles and sutterella : cerebellum autism)
https://www.ncbi.nlm.nih.gov/pubmed/8763977

HHV6 HLA-A2 (HHV6 and DTP : temporal lobe autism)

Note these 3 types of autism are hypothesis generated by me

Behcet's disease

Herpes simplex: HLA-B5
https://www.ncbi.nlm.nih.gov/pubmed/6586049

Behcet's and HLA-B5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857840/
http://rheumatology.oxfordjournals.org/content/51/5/887.full

Alopecia

HLA-DQ : Reovirus : Areata Alopecia
HLA-C : Polyomavirus: Universalis Alopecia
HLA-DR : Flu : Totalis Alopecia

http://angelabiggs.blogspot.com/2016/10/using-hlas-to-find-viral-suspects-for.html

Note that HLA-B27 signifies something in the mitochondria.  Looking into possibility that the small proteins made by viruses or infections to alter the mitochondria are picked up by the HLA-B27.

HLA-DP exists on the plasma membrane whereas the other HLAs have to move to the location.  Hence the reason HLA-DP triggers transplant rejection is that it is already there for the T-cells to look at.

HLA-E, HLA-F, and HLA-G are involved with pregnancy.  If we could figure out how to get tissues to express the fetus forms we could possibly end transplant rejection.

HLA-E cytosol fetus
HLA-F endoplasmic reticulum fetus
HLA-G fetal nucleus  (and mitochondria? )

No known  HLA-Dp for the fetus. Maybe this is not expressed at all? Which is why the fetus is not rejected?

Imagine a future of Petri-dish organs grown for transplant with only fetal HLAs expressed. :)