Tuesday, September 27, 2016

The eleven medical hypotheses which will change our lives

1. Allergies reveal the infections we have.  If an infection can be killed by a compound or inhibited by the compound we will have a reaction.  If an infection makes a pigment from a compound we will react to that too.

2. Infections talk to themselves using quorums. These quorums interfere with our body's pathways.(causing such things as type 2  diabetes, high cholesterol, and synuclein bodies)

3.. Autoimmune cross-targeting hypothesis:  The Cross-targeting of simultaneous infections on one tissue, one infection inside and one infections outside, triggers autoimmunity.  Antibodies or chemicals/drugs can replace one of the infections.  By antibodies I mean even those triggered by vaccines.

4. Co-carcinogenesis: a virus and a carcinogen together cause cancer. The carcinogen is a polymerase inhibitor which binds the viral polymerase with higher affinity.  Cancers wear the receptors that the virus that triggered it used to enter.

5. Barrier crossing infections, ones that can cross the intestine or the blood brain barrier, cause gluten sensitivity and allow other infections across with the hole they leave behind.

6. Viral families use receptor families.

7. Aflotoxin like compounds cause tau bodies.  ALS and picks disease are caused by different infections but both have tau.  Vitamin D is protective against it.

8. Pituitary tumors are caused by an infection releasing  butyrolactones which interfere with normal GABA signals and cause the immune system to confuse nerves with the infection.

9. There are 3 types of schizophrenia which match up with the 3 receptors use by the 3 herpes viruses. (sort of a continuation of 6)

10. Alzheimer's disease is caused by damage to the mitochondria: alpha-herpes family, diacetyl, inherited and linked to down syndrome, or radiation damaged mitochondria.

11. Postural orthostatic tachycardia could be caused by reoviruses and the adrenergic receptors they bind.


Monday, September 26, 2016

Myelodysplastic syndromes and idopathic thrombocytopenia have an overlap because they share viral infections

Myelodysplastic syndromes and idopathic thrombocytopenia have an overlap because they share viral infections: the EBV virus and flaviviruses.

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.
Autoimmune cross-targeting has a virus marking the inside of cells for immune attack.

Older post:
Benzene, leukemia, and these same viruses: EBV or flaviruses
http://angelabiggs.blogspot.com/2016/04/leukemia-and-co-carcinogenesis.html

Note that benzene alone, with no the virus there, would inhibit polymerases causing stunted cell division thus anemia.

benzene inhibits polymerases
http://www.ncbi.nlm.nih.gov/pubmed/3381009
http://www.ncbi.nlm.nih.gov/pubmed/2926830

Myelodysplastic syndromes

EBV and myeloma
http://www.ncbi.nlm.nih.gov/pubmed/22234097

Hepatitis C and myeloma (hepatitis C is a flavivirus)
http://www.ncbi.nlm.nih.gov/pubmed/16610042
http://news.cancerconnect.com/hepatitis-c-infection-increases-risk-of-lymphoma-and-multiple-myeloma/


Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.

Idopathic thrombocytopenia is a spirochete and a flavivirus or a flu virus or EBV

H.pylori (spirochete) and  thrombocytopenia
http://www.ncbi.nlm.nih.gov/pubmed/24574745
http://www.ncbi.nlm.nih.gov/pubmed/25728540
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177465/
http://www.ncbi.nlm.nih.gov/pubmed/27603101
http://www.ncbi.nlm.nih.gov/pubmed/27326941

Lyme (spirochete) and thrombocytopenia
http://cid.oxfordjournals.org/content/22/6/1119.full.pdf
http://ispub.com/IJID/2/2/3023
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882572/
http://www.ncbi.nlm.nih.gov/pubmed/8183774

previous post of thrombocytopenia
http://angelabiggs.blogspot.com/2014/09/is-idopathic-thrombocytopenic-purpura.html

EBV and thrombocytopenia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026329/





Schizophrenia and autoimmune cross-targeting of the amygdala with herpes virus....breaking up the 3 types of schizophrenia?

Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target cell type triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.

Schizophrenia and autoimmune cross-targeting of the amygdala.  Different infections on the amygdala will trigger schizophrenia as long as one infects the inside and one infects the outside.

we know the amydala is involved in schizophrenia and it's hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24619536
http://www.ncbi.nlm.nih.gov/pubmed/20071145

Schizophrenia and t.gondii has long been suspected
http://wwwnc.cdc.gov/eid/article/9/11/03-0143_article
http://www.medicalnewstoday.com/articles/284681.php

Other infections at the amygdala could cause it...but t.gondii has the most evidence so far.
(at the bottom of the page I will look at mycobacterias as another culprit. )

(Also note that the T.gondii group I suspect may have bee allergies where as the mycobacteria group are more likely to have shellfish allergies)

So what virus is infecting the inside? Several have been looked at:

herpes and t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/21991754

mother's antibodies to HSV-2 and a child with schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/15319094

resent onset schizophrenia antibodies: CMV and HHV6
https://www.ncbi.nlm.nih.gov/pubmed/14991372

Earlier post about hearing loss, schizophrenia, and newborns
http://angelabiggs.blogspot.com/2014/12/tgondii-and-cytomegalovirus-both.html

So which virus causes Schizophrenia by cross-targeting with t.gondii?

All 3 receptors are there at the amygdala and I believe they each cause a different type of schizophrenia based on the receptor they use....thus the 3 major types of schizophrenia.

(these receptor virus match ups are another hypothesis that is not proven but they help describe what we are seeing!!)

Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2,  herpes zoster : Estrogen-beta receptors (nerves and uterine tissue )

Beta-herpes viruses: CMV, HHV6, HHV7 :  Estrogen-related receptors (CMV binding confirmed)

Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)

the amygdala has estrogen alpha receptors and beta receptors
http://languagelog.ldc.upenn.edu/myl/ldc/llog/Brizendine/Jasnow2006.pdf
and estrogen-related receptor-gammas.

Can we divide these into different types of schizophrenia: disorganized, catatonic, paranoid?

The estrogen related receptors have been connected to spatial learning.
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-47134/
http://www.omim.org/entry/602969

Some schizophrenia has spatial learning issues
http://www.sciencedirect.com/science/article/pii/S2213158212000253
http://www.ncbi.nlm.nih.gov/pubmed/16048451

 Could this be the "disorganized schizophrenia" group be similar to spatial issues and linked to the Estrogen Related Receptors and CMV?

Could the catatonic group be linked to the estrogen alpha receptors? (and hsv1 hsv2 and zoster?)

alpha-receptors are strongly correlated with  social behaviors
http://www.ncbi.nlm.nih.gov/pubmed/12488114
http://www.ncbi.nlm.nih.gov/pubmed/9213137

schizophrenia and social behaviors?
http://www.ncbi.nlm.nih.gov/pubmed/20417974

catatonic and herpes simplex 1
http://www.ncbi.nlm.nih.gov/pubmed/21364369
http://www.ncbi.nlm.nih.gov/pubmed/6487432
http://www.ncbi.nlm.nih.gov/pubmed/6722708
http://www.ncbi.nlm.nih.gov/pubmed/4370982

Which might mean that paranoid schizophrenia would be the beta-receptors?

EBV uses beta receptors

When just paranoid schizophrenia was looked at only EBV antibodies were found.
http://www.sciencedirect.com/science/article/pii/S0920996411001605 

Looking at the estrogen receptor genes they found that alpha receptor and beta receptor differences in schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/22001950

estrogen appears to be protective for woman against schizophrenia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860106/

We have known that during hormonal fluxes estrogen psychosis can result
http://psychcentral.com/news/2010/01/21/estrogen-may-prevent-psychosis/10886.html

Mycobacterias might replace T.gondii as the large outer infection

Previously on this blog I connected Mycobacterias to type 2 diabetes and high cholesterol through the use of it's quorum cGMP

http://angelabiggs.blogspot.com/2015/12/mycobacterias-possible-connection-to.html

Schizophrenia and metabolic disorder
http://www.ncbi.nlm.nih.gov/pubmed/17685741

Schizophrenia and type 2 diabetes
http://www.mdedge.com/currentpsychiatry/article/64865/schizophrenia-other-psychotic-disorders/link-between-schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16280338
http://www.ncbi.nlm.nih.gov/pubmed/15538314

Schizophrenia and high cholesterol
http://www.sciencedirect.com/science/article/pii/S0165032705002995

psoriasis and schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/21985649
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928455/ (and mood disorders)
file:///Users/angelabiggs/Downloads/fulltext-schizophrenia-v2-id1006%20(2).pdf

note that those with both schizophrenia and bipolar are at the highest risk for metabolic syndrome
http://www.healthyplace.com/diabetes/mental-health/metabolic-syndrome/


Bipolar is cross-targeting of the Anterior cingulate

Bipolar 1 : T.gondii and CMV
(more common in children?)

Bipolar 2: mycobacteria and CMV
(overlaps with high cholesterol and type 2 diabetes)

Hyperthyroid caused Bipolar-like...connected to graves and RA?

Hoarding and depression: spirochetes secreting high cortisone...not autoimmune either no cycles


Alzheimer's and schizophrenia should exist only in the catatonic type 
Alzheimer's I had hypothesized caused by damaged mitochondrias.

In the case of Schizophrenia only one herpes virus type damages the mitochondria the Alpha herpes family including herpes zoster, HSV1, and HSV2 which uses the beta estrogen receptors. Beta-estrogen receptors cycle to the nerves mitochondria.

Alzheimer's and schizophrenia ....catatonic?
http://onlinelibrary.wiley.com/doi/10.1111/j.1479-8301.2007.00218.x/abstract
https://www.ncbi.nlm.nih.gov/pubmed/8732586
https://www.ncbi.nlm.nih.gov/pubmed/19748376
https://www.ncbi.nlm.nih.gov/pubmed/12788685
http://www.techtimes.com/articles/20929/20141125/the-surprising-link-between-alzheimers-and-schizophrenia.htm

Parkinson's, Lewy bodies, bipolar, and schizophrenia
This overlap can only be caused by the shared mycobacterias

Lewy bodies are caused by mycobacteria's quorum, cGMP, in the brain

Parkinson's is the autoimmune cross-targeting of mycobacteria with a virus (flavivirus or flu) at the substantia nigra.

Bipolar 2 is mycobateria and cmv at the anterior singulate.

Schizophrenia is the mycobacteria with a herpes virus at the amygdala.

Thus if you are unlucky and catch a mycobacteria you are vulnerable to these autoimmune reactions if it gets into your brain. (and then you catch viral infections hence these autoimmune diseases can appear in different orders)



Thursday, September 22, 2016

Acute Disseminated Encephalomyelitis (ADEM): are there multiple types? Autoimmune cross-targeting hypothesis suggests there should be because not all nerves have the same receptors.

Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target cell type triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.

Different viral infections can trigger ADEM and it seems logical that since these virus families use different receptors to enter the nerves....there should be different types of ADEM.

Zika and ADEM
http://www.medscape.com/viewarticle/861811

Zika could be using the ACTH receptor

ADEM and autism (measles vaccine in common?)
http://www.huffingtonpost.com/robert-f-kennedy-jr-and-david-kirby/vaccine-court-autism-deba_b_169673.htm

ADEM after vaccination for / or infection with measles, mumps, or rubella
http://www.ncbi.nlm.nih.gov/pubmed/19179725

 Paramyxoviridae (measles family viruses) bind Muscarinic receptors

ADEM has been PROVEN to be triggered by the rabies vaccine

ADEM has also been linked to Enteroviruses which bind Nicotinic acetylcholine receptors

ADEM and enteroviruses
http://www.ncbi.nlm.nih.gov/pubmed/20677593
http://www.ncbi.nlm.nih.gov/pubmed/25576193
http://www.ncbi.nlm.nih.gov/pubmed/17106158
http://www.ncbi.nlm.nih.gov/pubmed/11419405

Multiple sclerosis has associations with herpes zoster which by using the beta estrogen receptor hides in the mitochondria of the nerves.  Thus this form of autoimmune disease could possibly wax and wane with the herpes zoster virus.

Pervious blog posts about MS connect the mycobacteria of psoriasis with the herpes zoster virus as the possible triggers of MS.

It is possible that some cases of ADEM are mycobacterias crossed with other viruses that do not wax and wane. (I had connected high cholesterol and type 2 diabetes to the quorum of mycobacterias : cGMP so this might be the vulnerable group)

The paralysis caused by enteroviruses like polio and D68 are very likely to be autoimmune in nature because not everyone who catches these viruses develop paralysis.  An autoimmune cross-targeting of the spinal region instead of the brain?

Any thoughts?











Wednesday, September 21, 2016

What is the relationship of Chamomile (tea oil), urease secretion, H.pylori, C.sordellii, ulcerative colitis, and Takasyasu? Can enterotoxins explain lactose intolerance?

Chamomile inhibited the production of urease by H.pylori
http://www.ncbi.nlm.nih.gov/pubmed/17724768

C. Sordellii is urease positive
http://jb.asm.org/content/86/3/605.1.full.pdf

Chamomile and ulcerative colitis (improves the condition)
http://onlinelibrary.wiley.com/doi/10.1111/apt.12397/full

H.pylori causes stomach ulcers through the urease

It is my contention that C. sorderllii causes ulcerative colitis. Chamomile could help the condition by inhibiting the urease production of C. Sordellii

note that C.diff has been linked to antibiotic triggered pseudomembranous colitis
http://www.ncbi.nlm.nih.gov/pubmed/700321
http://www.ncbi.nlm.nih.gov/pubmed/549188

Aortic aneurysm and c. diff
http://www.jiac-j.com/article/S1341-321X(16)30141-6/abstract
http://www.ncbi.nlm.nih.gov/pubmed/22306098

Takasyasu (chronic inflammation the aorta of unknown etiology) and C. ulcerative colitis
http://www.ncbi.nlm.nih.gov/pubmed/25931203
http://www.ncbi.nlm.nih.gov/pubmed/25948351
http://www.ncbi.nlm.nih.gov/pubmed/21709638
http://www.japi.org/february2006/CR-151.pdf
http://www.medpagetoday.com/rheumatology/arthritis/52967
http://onlinelibrary.wiley.com/store/10.1002/art.39157/asset/art39157.pdf?v=1&t=itczssyy&s=63dfcd7cb7b58274d612a04683a2f1edf5306a81
http://www.govaresh.org/index.php/dd/article/view/833
http://content.onlinejacc.org/article.aspx?articleid=1361678
http://gut.bmj.com/content/31/7/831.full.pdf

Vasculitis in patients with ulcerative colitis
http://www.ncbi.nlm.nih.gov/pubmed/26315859


Could Takasyasu be connected to a C.sordellii infection?

Note that I have an unproven association of ulcerative colitis and daisy/mum allergies.  The chamomile flower is in the same flower family as daisies and mums.


c.diff and lactose intolerance are known to be linked
https://cdifffoundation.org/2013/07/05/suggested-foods-to-avoid-during-a-c-diff-infection/

Are the toxins of C. diff and C. sordellii the reason for the diarrhea?

ToxinA ( an enterotoxin)  and C.diff's diarrhea
https://en.wikipedia.org/wiki/Clostridium_difficile_toxin_A

Note that Lactose is a natural ligand of the toxin ricin and cholera
http://pubs.acs.org/doi/abs/10.1021/am900846r
https://www.ncbi.nlm.nih.gov/pubmed/20369893
https://www.ncbi.nlm.nih.gov/pubmed/12000304
https://www.ncbi.nlm.nih.gov/pubmed/7766178

Lactose is able to bind enterotoxins!!!!
http://www.nature.com/nature/journal/v355/n6360/abs/355561a0.html

Lactose intolerance and IBS (irritable bowel syndrome)
https://www.ncbi.nlm.nih.gov/pubmed/12439117
https://www.ncbi.nlm.nih.gov/pubmed/12591050
https://www.ncbi.nlm.nih.gov/pubmed/11407668
https://www.ncbi.nlm.nih.gov/pubmed/15380888
https://www.ncbi.nlm.nih.gov/pubmed/20522486

Summary: It is possible that the reactions of ulcerative colitis to dairy involve C.sordellii.  C.sordellii has an endotoxin that causes diarrhea and a urease that causes ulcers.  Lactose would bind both of these causing the bacteria to ramp up production.  Takasyasu could be when so much damage has occurred at the intestine S.sordellii has crossed over into the bloodstream's vessels?

Any thoughts?







Tuesday, September 13, 2016

Do Paramyxoviridae (measles family viruses) bind Muscarinic receptors?


Enteroviruses (coxsackie, polio etc) may bind nicotine receptors
http://angelabiggs.blogspot.com/2016/08/enteroviruses-and-nicotine.html

Nectin-like interactions of polio virus binding
http://www.ncbi.nlm.nih.gov/pubmed/25631086

Measles virus binds nectin-4
http://www.ncbi.nlm.nih.gov/pubmed/27483301

since polio virus binds nectins and measles binds nectin 4 is it possible that paramyxoviridae viruses bind muscarinic receptors?

do measles bind muscarinic receptors? Muscarinic receptors are found on smooth muscles.

eye and bladder have muscarinic receptors

neurogenic bladder after measles
http://www.ncbi.nlm.nih.gov/pubmed/2087429

bladder and muscarinic receptors
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751864/

Measles is the leading cause of childhood blindness !!!

Measles issues: croupy cough, loss of voice, swelling eyes, uncontrolled salivation

M1 receptors and eye development
https://www.ncbi.nlm.nih.gov/pubmed/20964868

joints and muscarinic receptors?
http://www.sciencedirect.com/science/article/pii/036192309190296V

measles and smooth muscle antibodies in joint of RA
http://ard.bmj.com/content/36/4/302.full.pdf+html
http://www.ncbi.nlm.nih.gov/pubmed/901028

muscarinic receptors and the cerebellum
http://www.ncbi.nlm.nih.gov/pubmed/23776234

M3 and cerebellum?
http://www.ncbi.nlm.nih.gov/pubmed/26823384

cerebellum type 2 and 3 muscarinic receptors
http://www.ncbi.nlm.nih.gov/pubmed/18358697

measles and cerebellum
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375852/

parainfluenza viruses
https://en.wikipedia.org/wiki/Human_parainfluenza_viruses

HPIV 1 and 2 cause CROUP

M2 receptors and croup?
https://www.ncbi.nlm.nih.gov/pubmed?term=9649578

HPIV 3 Bronchiolitis ( inflammation of the bronchioles)

Bronchioles have M3 receptors
https://en.wikipedia.org/wiki/Bronchoconstriction

Can't clearly match up viruses and muscarinic receptors: measles virus could bind more than one type?

Kids who had RSV can later have asthmatic reactions to viral infections...why?

eosinphils express muscarini receptors (M2)
http://digitalcommons.ohsu.edu/etd/540/

RSV and eosinphils: eosinphils as targets of infection
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741084/

eosinphils and measles (eosinphils increased)
http://jid.oxfordjournals.org/content/180/4/950.full

Are they increased to counter the numbers of eosinphils infected by the virus?

increased eosinphils in bronchial asthma
http://www.ncbi.nlm.nih.gov/pubmed/2215562

has the immune system adapted because of the RSV and started making more eosinphils each time?

Note that eosinphils are required for the development of plasma cells
http://www.ncbi.nlm.nih.gov/pubmed/21217761

Could doses of measles destroy eosinphil populations?

A woman was cured of plasma cell cell cancer (Myeloma) by measles virus treatments
http://www.medicalnewstoday.com/articles/276966.php

How did they "engineer" these cancer treatment measle viruses? could they infect cells but not replicate?










Sunday, September 11, 2016

Looking at Charles Richet's life, T.gondii, and hallucinations

Looking at Charles Richet's 1930 discovery of anaphylaxis and then his obsessions with the "sixth sense".

I can't help wonder these things:

France in general has a high infection rate of T.gondii.  This parasite which prefers the host of cats can also infect other mammals including cows, people, and dogs.

T. gondii has strong associations with Schizophrenia which involves hallucinations.  I have been suggesting that schizophrenia could be a cross-targeting autoimmune reaction of T.gondii and another infection in the brain.

During Charles Richet's lifetime the drink Absinthe was popular among the poor.  This worm wood green fairy drink was known to cause hallucinations in a percent of the population.

Richet was trying to explain the ability, the spiritual energy, as real not hallucinations. (was he himself infected?)

What if....this is a huge assumption and leap....what if the percent of the population that had hallucinations to Absinthe had t.gondii infections.

What if the Absinthe goes to the same area of the brain as the t.gondii thus causes the hallucinations similar to schizophrenia ?

Bee sting reactions and schizophrenia patients
http://www.ncbi.nlm.nih.gov/pubmed/5239954

What if the dogs that had fatal bee reactions in Richet's experiment had t.gondii infections too?

a toxin from sea anemone blocks potassium channels like honey bee toxin does.

T.gondii and T. cruzii have potassium channels
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0032264

T.gondii and t.cruzii infections and bee venom
http://www.ncbi.nlm.nih.gov/pubmed/23562368
https://www.researchgate.net/publication/277891898_14_In_vitro_Effects_of_Some_Bee_Products_on_T_gondii_Tachyzoites

I doubt that dogs are exposed to bees as much as bee keepers which currently seem to be the favored bee anaphylaxis allergy explanation now.

Does thujone play are role? Thujone is a compound in absinthe that acts on GABA receptors.  (not a high concentration) But if the number of receptors are increased in a person.

 Schizophrenia patients have increased GABA receptors.
http://www.ncbi.nlm.nih.gov/pubmed/16362364?dopt=Abstract

T.gondii and GABA receptors
http://mbio.asm.org/content/6/6/e01428-15.full
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003051