TLR are the butterfly nets catching in a nonspecific way. TLR3 and TLR8 are worn by dendritic cells and macrophages. TLR 7 and TLR9 are worn by B cells. If you match up the TLRs with the locations of the host cell they appear to catch things in this is the pattern you see.
TLR8 and Natural killer cells
TLR3 and natural killer cells
IFN is the coordination cytokine that triggers the correct HLA expression and Macrophage hands (Tyro3, AXL, Mer) .
Macrophage hands allow macrophages to attack virally infected cells.
HLAs are the mailboxes that hold up specific pieces to T cells or natural killer cells. It is my hypothesis that like the TLRs they are zone specific.
Note that the HLAs of the nucleus and the mitochondria are MHC1 : HLA-A and HLA-B and are worn by all cells. While MHC2 are worn by Antigen presenting cells like macrophages.
Tc cells look at MHC1
Th1cells look at MHC2: HLA-Dr, DQ, DP
NK cells look at HLA-C, HLA-E, HLA-F and HLA-G
The mailboxes for the NK cells involve the pathway of protein synthesis to the plasma membrane. If proteins can't make it to the plasma membrane then the cell would be "naked" and the NK cell would kill it anyway.