Autoimmune cross-targeting hypothesis: autoimmunity is triggered by a large infection marking the outside of a cell and a virus marking the inside of the cell.
The overlapping of autoimmune diseases could be due to a shared infection...in this case a herpes virus.
coexistance of ms and schizophrenia
Herpes zoster and CMV with schizophrenia
In MS the nerves are the target. Mycobacteria as the large infection and there are several possible viral triggers.
These are my guesses:
HLA-B: Herpes-alpha (zoster): Relapsing remitting
HLA-C: Polyomavirus (hepatitis B) or hep C- MCR4 flavivirus : primary progressive
HLA-DR15 : Flavivirus (? ) :Secondary progressive
HLA-A: Herpes-gamma (epstein barr): progressive relapsing (or CMV?)
In schizophrenia the large infection would t.gondii or fungal and then the virus would be a herpes. The herpes infection would overlap MS.
Schizophrenia : HLA-A/B
The 3 types of schizophrenia HLA match up with the 3 types of herpes viruses
DISORGANIZED : HLA-A2 and HLA-A11 : beta-herpes (CMV)
CATATONIC : HLA-B16 : Alpha-herpes (zoster, simplex)
PARANOID: HLA-A9 and HLA-A3 : Gamma Herpes (EBV)
relapsing remitting MS that overlaps with the catatonic schizophrenia
progressive relapsing MS that overlaps with the paranoid schizophrenia (EPV) or disorganized (CMV)