1. Allergy hypothesis: Allergies reveal the infections we have. Severe allergies and infections can be matched up: peanut and Staph, bee and T.gondii, daisy and Clostridium, poison ivy and spirochetes. If an infection can be killed by a compound or inhibited by the compound our immune system sees the interaction and we associate all the compounds present with the infection. If an infection makes a pigment from a compound we will react to that too. For example aflatoxin with peanuts could cause staph to counter respond. Our immune system would identify everything there at the scene of the crime as part of the infection.
2. Quorum hypothesis: Infections talk using quorums. These quorums interfere with our body's pathways. ( for example mycobacteria's cGMP causes such things as type 2 diabetes, high cholesterol, and synuclein bodies)
3.. Autoimmune cross-targeting hypothesis: The Cross-targeting of simultaneous infections on one tissue, one infection inside and one infections outside, triggers autoimmunity. Antibodies or chemicals/drugs can replace one of the infections. By antibodies I mean even those triggered by vaccines. For example a flu virus inside of the pancreas and e.coli latching on to the outside could trigger type one diabetes.
4. Co-carcinogenesis: a virus and a carcinogen together cause cancer. Taking Rous’ hypothesis further, the carcinogen is a polymerase inhibitor which binds the viral polymerase with higher affinity. Thus the DNA methylation state has been changed but the virus is no longer viable. DNA damage does not cause most cancers, the interaction of carcinogens and viruses do. Further these cancers wear the receptors that the virus that triggered it used to enter and the characteristics of the cancer will be from the receptor's pathways.
5. Barrier crossing infections are ones that can cross the intestine or the blood brain barrier causing gluten sensitivity with the hole they leave behind. This explains the gluten sensitivity of Schizophernia from T.gondii, Celiac disease from e.coli, Tourettes from staph, and crohn’s from mycobacteria.
6. Viral families use receptor families. Influenzas use dopamine receptors. HPVs use Cannabinoid receptors. Herpes viruses use estrogen and estrogen-like receptors. Flaviviruses use melanocortin receptors. Polyomaviruses use serotonin receptors.
7. Aflatoxin like compounds cause tau bodies. ALS and picks disease are caused by different infections but both have tau. Both infections secrete an aflatoxin like compound. Vitamin D is protective against it because aflatoxin uses the vit D receptor.
8. Pituitary tumors are caused by an infection releasing butyrolactones which interfere with normal GABA signals and cause the immune system to confuse nerves with the infection. (or someone taking too many GHB sleeping pills)
9. The receptors used by a virus when triggering autoimmunity cause pathways to be activated which makes the various types of one autoimmune disease. There are 3 types of schizophrenia which match up with the 3 receptors use by the 3 herpes viruses. (sort of a continuation of 6)
The receptor pathway triggered by a virus involved in an autoimmune disease can cause symptoms of the disease that will be distinct. Example: The 3 types of schizophrenia has all 3 herpes virus families and each receptor activated can be matched to symptoms. Estrogen-related receptor and disorganized symptoms for example. 3 receptors used equals 3 types of schizophrenia
10. Alzheimer's disease is caused by damage to the mitochondria: alpha-herpes family, diacetyl, inherited and linked to down syndrome, or radiation damaged mitochondria.
11. Postural orthostatic tachycardia could be caused by reoviruses and the adrenergic receptors they bind.
12. The HLAs are mailboxes for T cells from different areas of the cell. HLA-A is the nuclear mailbox. HLA-B is the mitochondria's mailbox. HLA-C is the endoplasmic reticulum's mailbox. HLA-DR is the cytosol's mailbox for RNA viruses. HLA-DQ is the cytosol's mailbox for non-encapsulated viruses there. HLA-DP is the plasama membrane mailbox.
13. Carcinogens use certain receptors to get into cells which matches them up with specific cancers.
14. TLRs, toll like receptors, are the innane immune system of nets catching conserved molecules in a non specific way but identifying the region as well as general type of infection. Like HLAs they exist in the different areas of the cell. When the internal viral seeking TLRs are activated the IFN matches the region they are in thus the appropriate HLA is produced helping to find the exact culprit.
15. TLRs send IFNs which tells infected cells to express the corresponding HLAs and macrophages to wear the corresponding TAMs (hands to grab infected cells)
Cytosol TLR3 IFNbeta HLA-D Tyro3
Nucleus/ Mito TLR7/9 IFNalpha HLA-A HLA-B Mer
Endoplasmic R TLR 8 IFNgamma HLA-C Axl
(because an ER infected means little gets to the surface of a cell Natural killer cells step in here and secrete IFNgamma)
16. Nuclear viruses awaken embryonic Hervs. They do so by methylating or demethylating DNA. If the virus family demethylates the cancer will be aggressive while the methylating viruses are slow growing. (Cancer occurs when a carcinogen inhibits the viral polymerase..so the virus opens the DNA up but can't use it)