tag:blogger.com,1999:blog-23991234314114084622024-03-12T15:03:08.309-07:00Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.comBlogger591125tag:blogger.com,1999:blog-2399123431411408462.post-12749291610337577472020-05-19T12:40:00.001-07:002020-07-29T07:06:40.420-07:00Is Kawasaki disease an autoimmune disease caused by the cross-targeting of two infections? <div dir="ltr" style="text-align: left;" trbidi="on">
Autoimmune cross-targeting hypothesis: Two infections on one target tissue. One infection involves infecting inside of cells the other outside of the cells of the target tissue.<br />
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Kawasaki as an autoimmune disease<br />
<a href="https://pubmed.ncbi.nlm.nih.gov/25882057/?from_term=kawasaki+disease+autoimmune&from_pos=9">https://pubmed.ncbi.nlm.nih.gov/25882057/?from_term=kawasaki+disease+autoimmune&from_pos=9</a><br />
<br />
<a href="https://pubmed.ncbi.nlm.nih.gov/31013925/?from_term=kawasaki+disease+autoimmune&from_pos=2">https://pubmed.ncbi.nlm.nih.gov/31013925/?from_term=kawasaki+disease+autoimmune&from_pos=2</a><br />
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The inner viral infections:<br />
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Viruses associated with Kawasaki disease : enterovirus adenovirus rhinovirus and <b>coronavirus</b><br />
<a href="https://www.sciencedirect.com/science/article/pii/S0929664614000035">https://www.sciencedirect.com/science/article/pii/S0929664614000035</a><br />
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coronavirus<br />
<a href="https://pubmed.ncbi.nlm.nih.gov/15655771/?from_term=kawasaki+coronavirus&from_pos=1">https://pubmed.ncbi.nlm.nih.gov/15655771/?from_term=kawasaki+coronavirus&from_pos=1</a><br />
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The outer bacterial infections:<br />
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Strep and Kawasaki<br />
<a href="https://www.npjournal.org/article/S1555-4155(12)00621-6/pdf">https://www.npjournal.org/article/S1555-4155(12)00621-6/pdf</a><br />
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Location is more important than the type of virus when triggering autoimmune disease. If an infections exists inside of a cell as well as outside then an autoimmune response is triggered.<br />
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Coronavirus infection increases the binding of bacterial infections<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168281/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168281/</a><br />
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<span style="background-color: white; color: #1b1c2a; font-family: "georgia"; font-size: 16px;">Naphthalene/shampoo from carpet cleaning could trigger Kawasaki how? which infection does it replace ?</span><br />
<a href="https://pubmed.ncbi.nlm.nih.gov/6125730/">https://pubmed.ncbi.nlm.nih.gov/6125730/</a><br />
<a href="https://pubmed.ncbi.nlm.nih.gov/2020511/">https://pubmed.ncbi.nlm.nih.gov/2020511/</a><br />
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naphthalene and ER stress<br />
<a href="https://www.dovepress.com/67-dihydroxy-2-4prime-hydroxyphenylnaphthalene-induces-hct116-cell-apo-peer-reviewed-article-DDDT">https://www.dovepress.com/67-dihydroxy-2-4prime-hydroxyphenylnaphthalene-induces-hct116-cell-apo-peer-reviewed-article-DDDT</a><br />
napthalene and ER damage<br />
<a href="https://www.sciencedirect.com/science/article/abs/pii/0022201185901090">https://www.sciencedirect.com/science/article/abs/pii/0022201185901090</a><br />
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Covid-19 and multisystem inflammatory syndrome<br />
<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2021680">https://www.nejm.org/doi/full/10.1056/NEJMoa2021680</a><br />
<a href="https://www.statnews.com/2020/06/29/nejm-inflammation-children-covid19-misc/">https://www.statnews.com/2020/06/29/nejm-inflammation-children-covid19-misc/</a></div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com1tag:blogger.com,1999:blog-2399123431411408462.post-88392517689175942662020-03-30T16:56:00.001-07:002020-05-19T13:58:44.417-07:00Immune system cells involved with antigens outside of cells evolve from the yolk<div dir="ltr" style="text-align: left;" trbidi="on">
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Resident tissue macrophage<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675852/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675852/</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/26992565">https://www.ncbi.nlm.nih.gov/pubmed/26992565</a><br />
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langerhans<br />
<a href="https://link.springer.com/chapter/10.1007/978-1-4757-9966-8_76">https://link.springer.com/chapter/10.1007/978-1-4757-9966-8_76</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/22565823">https://www.ncbi.nlm.nih.gov/pubmed/22565823</a><br />
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M cells and GH<br />
<a href="https://joe.bioscientifica.com/view/journals/joe/147/3/joe_147_3_002.xml">https://joe.bioscientifica.com/view/journals/joe/147/3/joe_147_3_002.xml</a><br />
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B1 and B2 cells<br />
<a href="https://www.sciencedaily.com/releases/2019/02/190215082333.htm">https://www.sciencedaily.com/releases/2019/02/190215082333.htm</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com1tag:blogger.com,1999:blog-2399123431411408462.post-39452956651143284502019-09-29T15:28:00.000-07:002019-09-29T15:28:04.877-07:00Autoimmunity of the Brain: two tertiary lymph regions<div dir="ltr" style="text-align: left;" trbidi="on">
Autoimmune disease in the area of the brain: Autoimmune hypothesis is that two infections on one target trigger autoimmunity but one infection must be an outside infection and the other an inside infection.<br />
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Neuromyelitis Optica which has antibodies to aquaporin disrupts the blood brain barrier.<br />
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Neuromyelitis has been linked to both mycobacterias and viruses like dengue.<br />
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Eosinophils and aquaporin-4<br />
<a href="https://www.sciencedirect.com/science/article/pii/S096758681731069X">https://www.sciencedirect.com/science/article/pii/S096758681731069X</a><br />
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Mycobacteria (TB) and Neuromyelitis<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938476/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938476/</a><br />
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mycobacteria and swelling of the choroid plexus<br />
<a href="https://journals.sagepub.com/doi/abs/10.1177/0284185116633913?journalCode=acrc">https://journals.sagepub.com/doi/abs/10.1177/0284185116633913?journalCode=acrc</a><br />
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lymph structure in choroid plexus<br />
<a href="https://insight.jci.org/articles/view/124203">https://insight.jci.org/articles/view/124203</a><br />
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dengue virus can trigger Neuromyelitis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/29475624">https://www.ncbi.nlm.nih.gov/pubmed/29475624</a><br />
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dengue and the BBB<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606788/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606788/</a><br />
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B cells and the blood brain barrier<br />
<a href="https://www.jci.org/articles/view/63842">https://www.jci.org/articles/view/63842</a><br />
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in MS two groups of B cells: BBB and choroid plexus<br />
<a href="https://onlinelibrary.ectrims-congress.eu/ectrims/2016/32nd/146268/brigitte.wildemann.cns-transmigration.of.distinct.b-cell.subsets.through.the.html">https://onlinelibrary.ectrims-congress.eu/ectrims/2016/32nd/146268/brigitte.wildemann.cns-transmigration.of.distinct.b-cell.subsets.through.the.html</a><br />
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meningitis (bacteria) and choroid plexus<br />
<a href="https://journals.sagepub.com/doi/abs/10.1177/197140091002300507?journalCode=neub">https://journals.sagepub.com/doi/abs/10.1177/197140091002300507?journalCode=neub</a><br />
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viral infections of the brain and the blood brain barrier<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367119/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367119/</a><br />
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Consider the two zones of the lymph split in the brain into literally two different regions.<br />
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Where the choroid plexus deals with the outer antigens and the blood brain barrier is the inner antigens.<br />
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<br />
For mycobacteria the main outside pathway involves Eosinophils. So the IgG4 is created to stop the eosinophils.</div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-47894786357354594362019-09-02T06:16:00.003-07:002019-10-19T15:22:30.827-07:00IgG4 antibodies and shutting down outer pathways...considered again.<div dir="ltr" style="text-align: left;" trbidi="on">
IgG4 are the autoimmune antibodies which shut down the outer pathway so the immune system can focus on the inside pathway.<br />
<br />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Autoimmune hypothesis: Two infections on one target triggers autoimmune disease. One infection inside and one infection outside of the cell.</span><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;"></span><b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;">Does the B cell that gets pulled from outside antigen pathways to inside antigen pathways become the IgG4 producing B cell with the goal of shutting down the outside pathways?</b><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">This would mean that the IgG4 would be similar based on the large infection and the pathway stopped if the autoimmune diseases share the same large infection. For example, all mycobacteria triggered autoimmune diseases would have the same IgG4 against aquaporins.</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;">IgG4 antibodies represent a down-regulatory response</b><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><a href="https://www.ncbi.nlm.nih.gov/pubmed?term=24111912" style="color: #6699cc; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pubmed?term=24111912</a></b><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;"></span><b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;">IgG4 made by Bcells that produce il-10</b><br />
<a href="https://www.jacionline.org/article/S0091-6749(13)00150-4/pdf" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.jacionline.org/article/S0091-6749(13)00150-4/pdf</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Br1 up regulate the plasma cells to become IgG4 producing</span><br />
<a href="https://www.jacionline.org/article/S0091-6749(16)30722-9/pdf" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.jacionline.org/article/S0091-6749(16)30722-9/pdf</a><br />
<br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;">Anti-gangliosides</b><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Involves vacuole bacteria</span><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Guillian-barre and anti-gangliosides</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422685/" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422685/</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<a href="http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=5;spage=1324;epage=1331;aulast=Baskar" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=5;spage=1324;epage=1331;aulast=Baskar</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<a href="https://www.researchgate.net/publication/325884578_Anti-ganglioside_Antibodies_in_Peripheral_Nerve_Pathology" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.researchgate.net/publication/325884578_Anti-ganglioside_Antibodies_in_Peripheral_Nerve_Pathology</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<br />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">il-15 and gangliosides</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/16116192" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pubmed/16116192</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">gangliosides in autism</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/9766735" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pubmed/9766735</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">sutterella and autism spectrum disorder</span><br />
<a href="https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-4-42" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-4-42</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;">Anti-ANCA / anti-ANA</b><br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">involves golgi infections and neutrophils </span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">salmonella and anti-ANCA</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905360/" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905360/</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">reactive arthritis and salmonella</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195798/" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195798/</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">anti-ANCA bind the neutrophil traps</span><br />
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2017.00439/full" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.frontiersin.org/articles/10.3389/fimmu.2017.00439/full</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Anti-ANCA and Rheumatoid</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552688/" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552688/</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">anti-nuclear in strep with tourettes</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/12699862" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pubmed/12699862</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">TLR8 and strep</span><br />
<a href="http://www.jimmunol.org/content/195/3/1092" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">http://www.jimmunol.org/content/195/3/1092</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">TLR8 is the Tcell mailbox for the Endoplasmic reticulum</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">polyarthritis and strep</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803937/" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803937/</a><br />
<br />
<b>Anti-CCP</b><br />
<br />
involves ER infections (by mycoplasmas) and the neutrophils<br />
<br />
autophagy and ER stress<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/26391548">https://www.ncbi.nlm.nih.gov/pubmed/26391548</a><br />
<br />
autophagy generates citrullinated proteins<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/27074807">https://www.ncbi.nlm.nih.gov/pubmed/27074807</a><br />
<br />
neutrophils and citrullinated proteins in RA<br />
<a href="https://www.nature.com/articles/s41598-018-33385-z">https://www.nature.com/articles/s41598-018-33385-z</a><br />
<br />
some how this antibody stops the neutrophils from coming for mycoplasmas?<br />
<br />
<b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;"><br /></b><b style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;">Anti-leiomodin</b><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Nodding disease is triggered by the parasitic worm and what virus? The IgG4 was found against leiomodin-1. Nodding disease is autoimmune disease of the skin where the autoantigen attacks the brain?</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Autoimmune cross-targeting hypothesis: two infections on one tissue. The reaction is at the skin but then the antibody attacks the brain?</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;"> For these worms how does this work? The Leiomodin-1 antibody bound the worms...but they were IgG4?</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">When exposed to cold temperatures or food the children nod their heads uncontrollably. The hippocampus of the brain is responsible for body temperature sensations and hunger urges.</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">The worm is not in the hippocampus but the autoantibody shows up there.</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/28202777" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pubmed/28202777</a><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Which virus at the skin has co-infected and caused the IgG4?</span><br />
<br style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">Does this mean that leiomodin-1 is involved with eosinophils degranulation attack? Since eosinophils at the main cell type attacking the worms how would this work?</span><br />
<br class="Apple-interchange-newline" style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px;" />
<span style="background-color: white; color: #333333; font-family: "georgia" , "utopia" , "palatino linotype" , "palatino" , serif; font-size: 14.85px;">eosinophils and smooth muscles</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/23180361" style="background-color: white; color: #6699cc; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-decoration-line: none;">https://www.ncbi.nlm.nih.gov/pubmed/23180361</a><br />
<br />
<div class="separator" style="background-color: white; clear: both; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjaxHiWWYxNVScdXHjKAi96zluTfuVmZaITn5nBpBSoOfCA14t2styJLQVwpe72IPH4V40ZVGmx5-h0PlGuPbrzLwVHIGqQ-cYJAXQLcUQGSeaUkIznOjVBV4_lfqRPwkAfnjBvB16c9SQ/s1600/IMG_20190519_170454.jpg" imageanchor="1" style="color: #6699cc; margin-left: 1em; margin-right: 1em; text-decoration-line: none;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjaxHiWWYxNVScdXHjKAi96zluTfuVmZaITn5nBpBSoOfCA14t2styJLQVwpe72IPH4V40ZVGmx5-h0PlGuPbrzLwVHIGqQ-cYJAXQLcUQGSeaUkIznOjVBV4_lfqRPwkAfnjBvB16c9SQ/s640/IMG_20190519_170454.jpg" style="border: none; position: relative;" width="480" /></a></div>
<br />
<span style="color: #cc0000;">NEW</span><br />
<br />
<b>Natural killer cells anti-TRR</b><br />
<br />
JIA IgG4 antibody to TRR<br />
<a href="https://www.sciencedaily.com/releases/2016/02/160225101100.htm">https://www.sciencedaily.com/releases/2016/02/160225101100.htm</a><br />
<br />
TTR is a serum cerebrospinal fluid carrier of thyroid hormone thyroxine T4<br />
<a href="https://www.acrobiosystems.com/L-514.html?utm_source=google&utm_medium=keywords&utm_campaign=US-proteinno-core-PC&utm_content=hhhis&utm_term=Transthyretin&gclid=Cj0KCQjw2K3rBRDiARIsAOFSW_7MhivjRGdtDNRxMtjDu6ncdwisF-Hr002WWJBfblMQl-yYluCc8ZsaAqbEEALw_wcB">https://www.acrobiosystems.com/L-514.html?utm_source=google&utm_medium=keywords&utm_campaign=US-proteinno-core-PC&utm_content=hhhis&utm_term=Transthyretin&gclid=Cj0KCQjw2K3rBRDiARIsAOFSW_7MhivjRGdtDNRxMtjDu6ncdwisF-Hr002WWJBfblMQl-yYluCc8ZsaAqbEEALw_wcB</a><br />
<br />
Natural killer cells and Thyroid hormones<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/21745103">https://www.ncbi.nlm.nih.gov/pubmed/21745103</a><br />
<br />
Do mycoplasmas which infect the endoplasma reticulum trigger NK cells but then in the autoimmune cross-targeting event the NK need to be "turned off"?<br />
<br />
thyorid and nk cells associated in women with reproductive failure<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806729/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806729/</a><br />
<br />
TTR and arthritis<br />
<a href="https://www.researchgate.net/figure/TTR-expressions-were-examined-in-other-joint-disease-and-autoimmune-disease-such-as-OA_fig4_261515697">https://www.researchgate.net/figure/TTR-expressions-were-examined-in-other-joint-disease-and-autoimmune-disease-such-as-OA_fig4_261515697</a><br />
<br />
nk and rheumatoid arthritis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/30718650">https://www.ncbi.nlm.nih.gov/pubmed/30718650</a><br />
<br />
<b>Eosinophils and degranulation</b><br />
<br />
anti-fab IgG4<br />
<a href="https://link.springer.com/article/10.1007/BF00269196">https://link.springer.com/article/10.1007/BF00269196</a><br />
<br />
FAB is the part of the antibody bound to the FC receptor by cells like Eosinophils<br />
<br />
RA and FAB<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/3928684">https://www.ncbi.nlm.nih.gov/pubmed/3928684</a><br />
<br />
<b>Anti-myelin for mycobacteria in cytosol and eosinophils </b><br />
<br />
anti-myelin for lyme<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/11987581">https://www.ncbi.nlm.nih.gov/pubmed/11987581</a><br />
<br />
Aquaporin and Eosinophils (phagocytosis)<br />
<br />
<b>Anti-Aquaporin (from old post)</b><br />
<b><br /></b>Mycobacteria and other bacterial cytosol / nuclear infections which involve eosinophils and macrophages in a phagocytosis method appear to develop anti-AQP ( aquaporin antibodies)<br />
<br />
aquaporins move eosoinophils<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/18510218">https://www.ncbi.nlm.nih.gov/pubmed/18510218</a><br />
<br />
anti-aquaporin4 and multiple sclerosis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/20705110">https://www.ncbi.nlm.nih.gov/pubmed/20705110</a><br />
<br />
mycobacteria and multiple sclerosis<br />
<a href="https://www.sciencedaily.com/releases/2010/02/100226084007.htm">https://www.sciencedaily.com/releases/2010/02/100226084007.htm</a><br />
<br />
idiopathic demyelination and anti-AQP4<br />
<a href="https://www.hindawi.com/journals/msi/2017/1359761/">https://www.hindawi.com/journals/msi/2017/1359761/</a><br />
<br />
anti-aquaporin4 in neuromyelitis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/18808744">https://www.ncbi.nlm.nih.gov/pubmed/18808744</a><br />
<br />
salivary glands and parkinson's disease<br />
<a href="https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=838">https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=838</a><br />
<br />
salivary gland and psoriasis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/7165375">https://www.ncbi.nlm.nih.gov/pubmed/7165375</a><br />
<br />
salivary glands and aquaporins<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783900/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783900/</a><br />
<br />
parkinson's and mycobacteria<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/25459140">https://www.ncbi.nlm.nih.gov/pubmed/25459140</a><br />
<br />
psoriasis and mycobacteria<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/9657322">https://www.ncbi.nlm.nih.gov/pubmed/9657322</a><br />
<br />
aquaporin and psoriasis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/21400035">https://www.ncbi.nlm.nih.gov/pubmed/21400035</a><br />
<br />
(Candida also has portions move to the cytosol)<br />
<br />
SJ and salivary<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/1055974">https://www.ncbi.nlm.nih.gov/pubmed/1055974</a><br />
<br />
Candida and SJ<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/12973284">https://www.ncbi.nlm.nih.gov/pubmed/12973284</a><br />
<br />
SJ and MS because of salivary<br />
<a href="https://www.jwatch.org/jn200112200000006/2001/12/20/possible-association-between-sjogrens-syndrome">https://www.jwatch.org/jn200112200000006/2001/12/20/possible-association-between-sjogrens-syndrome</a><br />
<br />
<b>Anti-TPO</b><br />
<br />
How would anti-TPO stop TH17 cells which combat fungal infections<br />
<br />
TPO increases the numbers of TH17<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/26836805" style="background-color: white;">https://www.ncbi.nlm.nih.gov/pubmed/26836805</a><br />
<br />
TH17 and fungal infections<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/19283705">https://www.ncbi.nlm.nih.gov/pubmed/19283705</a><br />
<br />
quorum of fungus: farnesol<br />
<a href="https://www.ingentaconnect.com/contentone/govi/pharmaz/2017/00000072/00000006/art00001?crawler=true&mimetype=application/pdf">https://www.ingentaconnect.com/contentone/govi/pharmaz/2017/00000072/00000006/art00001?crawler=true&mimetype=application/pdf</a><br />
<br />
Does farnesol stimulate the thyroid to produce TPO? Is TPO used by TH17 cells?<br />
<br />
Would blocking TPO stop TH17 cells?<br />
<br />
original post<br />
I have looked at these pathways before <a href="https://angelabiggs.blogspot.com/2019/05/igg4-antibodies.html">https://angelabiggs.blogspot.com/2019/05/igg4-antibodies.html</a><br />
<br />
<br />
<br />
<br />
<br />
<br /></div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com4tag:blogger.com,1999:blog-2399123431411408462.post-20076746387710164472019-08-27T08:42:00.002-07:002019-08-27T09:37:24.840-07:00HLA-dr contemplations <div dir="ltr" style="text-align: left;" trbidi="on">
<br />
<b><br /></b>
<b>HLA-dr</b><br />
<br />
HLA-dr appears to hold virus RNA<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/10564819">https://www.ncbi.nlm.nih.gov/pubmed/10564819</a><br />
<br />
<br />
<b>HLA-dq</b><br />
<br />
HLA-dq appears to hold small antigens like insulin and gliadin<br />
<br />
presentation of gluten in HLA-dq2<br />
<a href="https://www.jimmunol.org/content/175/1/254">https://www.jimmunol.org/content/175/1/254</a><br />
<br />
"<span style="background-color: white; font-family: "open sans"; font-size: 14px;">It is interesting to note that even if the risk for developing CD associated with DQ2.2 is minuscule compared with that of DQ2.5, a recent study revealed that among the small group of DQ2.5- and DQ8-negative CD patients,</span><span style="background-color: white; font-family: "open sans"; font-size: 14px;"> "</span><br />
<br />
<br />
e.coli binds gliadin<br />
<a href="https://pdfs.semanticscholar.org/b70f/23916b8f5553baf3a01055725ab9c68add7c.pdf?_ga=2.119014538.2026673398.1566778373-1275520869.1527777598">https://pdfs.semanticscholar.org/b70f/23916b8f5553baf3a01055725ab9c68add7c.pdf?_ga=2.119014538.2026673398.1566778373-1275520869.1527777598</a><br />
<br />
HLA-dp and type one diabetes<br />
<a href="https://link.springer.com/article/10.1007/s10654-004-5176-9">https://link.springer.com/article/10.1007/s10654-004-5176-9</a><br />
<br />
HLA-dq8 holds insulin<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/11376336">https://www.ncbi.nlm.nih.gov/pubmed/11376336</a><br />
<br />
<br />
<b>HLA-dp</b><br />
<br />
HLA-dp appears to hold a significant amount of self antigens as well as foreign and is similar to HLA-dq but is not used as often<br />
<br />
HLA-dp review<br />
<a href="https://www.jimmunol.org/content/184/5/2492">https://www.jimmunol.org/content/184/5/2492</a><br />
states that it has a lower expression than HLA-dr or HLA-dq and that HLA-dp has few epitopes. HLA-dp is shared by 90% of the population<br />
<br />
HLA-dq has been associated with ALL the childhood leukemia (genetic form) ????<br />
<a href="http://www.bloodjournal.org/content/120/15/3039.short?sso-checked=true?sso-checked=true">http://www.bloodjournal.org/content/120/15/3039.short?sso-checked=true?sso-checked=true</a><br />
<br />
What is the difference between HLA-dq and dp?<br />
<br />
<br />
might not be relevant:<br />
<br />
beryllium binds to HLA-dp<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/11423174">https://www.ncbi.nlm.nih.gov/pubmed/11423174</a><br />
<br />
cobalt binds to HLA-dp<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/10427976">https://www.ncbi.nlm.nih.gov/pubmed/10427976</a><br />
<br />
<br />
<br /></div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-66323362835798036742019-08-23T10:40:00.001-07:002019-08-23T12:07:29.749-07:00How does gluten fit into the autoimmune cross-targeting hypothesis?<div dir="ltr" style="text-align: left;" trbidi="on">
New hypothesis: Two separate zones for inner and outer antigens in lymph organs.<br />
<br />
ILF the inducible lymph follicle deals with the inner antigens while the peyer patch deals with the outer antigens of the mucosal membranes.<br />
<br />
ILF <a href="https://www.ncbi.nlm.nih.gov/pubmed/12759424">https://www.ncbi.nlm.nih.gov/pubmed/12759424</a><br />
<br />
E.coli infections would involve the outer pathways. <b>At the mucosal's peyer patch they would see high growth hormone GH thus produce IgA.</b><br />
<br />
According to the Cross-targeting hypothesis when a second inner infection appears and calls the B cell to the ILF zone and away from the peyer patch....the B cell becomes a regulatory autoimmune B cell which secretes IgG4 antibodies that stop the outer pathways.<br />
<br />
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<br />
GH-IGF axis and gluten in celiac<br />
<a href="https://www.karger.com/article/pdf/185499">https://www.karger.com/article/pdf/185499</a><br />
<br />
Gluten was seen as the infection not the parasite because the parasite moved inside of cells?<br />
<br />
UPEC :the e.coli that moves inside cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244466/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244466/</a><br />
<br />
If patients remove gluten and outside pathway is stopped? Is that because the infection is on the inside of cells but gluten was seen as the infection?<br />
<br />
Note that the anti-gluten antibody is not IgG4 but IgG1.<br />
<br />
gluten and e.coli in mice<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630176/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630176/</a><br />
<br />
e.coli and celiac<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287676/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287676/</a><br />
<br />
? protein from e.coli binds gliadin?<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/16944918">https://www.ncbi.nlm.nih.gov/pubmed/16944918</a><br />
<br />
Do these infection hold gluten on the outside like a cloak?<br />
<br />
Anti-gluten response after t.gondii infection in mice?<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/23209841">https://www.ncbi.nlm.nih.gov/pubmed/23209841</a><br />
<br />
anti-gluten and t.gondii<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/22446142">https://www.ncbi.nlm.nih.gov/pubmed/22446142</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com2tag:blogger.com,1999:blog-2399123431411408462.post-90651900200152755972019-08-21T15:47:00.001-07:002019-08-24T12:09:00.333-07:00The Secondary Lymph organs have separate zones for inner and outer antigens<div dir="ltr" style="text-align: left;" trbidi="on">
The secondary lymph organs are strategically situated to intercept infections. The lymph glands capture the infections that breach the skin's barrier. The ILF and peyer patches guard the mucosal membranes. The blood brain barrier and the choroid plexus protects the brain. The spleen filters the blood removing not just dead blood cells but infections that have reached there. The omentum monitors and protects the peritoneal cavity which contains the stomach, the liver, the large and small intestines, the kidneys, the gall bladder, the pancreas, and the adrenal glands.<br />
<br />
All secondary lymph organs have separate zones for fighting inner and outer antigens.<br />
<br />
The inner antigens are processed by embryonic HSC derived macrophages. These macrophages communicate with and pass antigens to marginal reticular stromal cells or Astrocyte stromal cells. These cells with antigen evolve into follicular dendritic cells and secrete CXCL13 calling the B and the T cells to them. The dendritic cells are derived from adult HSC monocytes. These monocyte derived dendritic cells are the antigen presenting cells to the T cells. For inner antigens the T cell makes the determination at this point if the antigen is foreign.<br />
<br />
The outer antigens are collected by langerhans, marginal zone B cells, B1, or Resident Tissue macrophages (of the CP) all of which differentiated from the yolk sac not the HSC of the bone marrow. These yolk sac derived cells communicate and pass antigens on to fibroblastic reticular stromal cells. These antigen holding FRC become follicular dendritic cells with B7-2 involvement and secrete CXCL13. These FDC cells hand the antigen off to B cells who do the antigen presenting to the T cell. For outer antigens the B cell determines if the antigen is foreign.<br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com1tag:blogger.com,1999:blog-2399123431411408462.post-90601954895227485992019-08-21T14:00:00.003-07:002019-09-05T14:26:30.021-07:00The 2 antigen zones of the peritoneal cavity<div dir="ltr" style="text-align: left;" trbidi="on">
The omentum protects the peritoneal cavity<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812451/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812451/</a><br />
<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754314/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754314/</a><br />
<br />
the peritoneal cavity contains the stomach, liver, large and small intestines, the kidneys, the gall bladder, pancreas, and the adrenal glands.<br />
<br />
omentum stromal cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481843/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481843/</a><br />
<br />
there are two types of omentum cells involved in tissue repair as stromal cells<br />
myeloid derived suppressor cells and MSC cells<br />
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038368">https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038368</a><br />
<br />
pericytes and myeloid derived suppressor cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/26296362">https://www.ncbi.nlm.nih.gov/pubmed/26296362</a><br />
<br />
subgroup of myeloid derived suppressor cells : fibrocytes<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/26405600/">https://www.ncbi.nlm.nih.gov/pubmed/26405600/</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/23757729">https://www.ncbi.nlm.nih.gov/pubmed/23757729</a><br />
<br />
fibrocytes are potent stimulators of T cytotoxic cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/15767291">https://www.ncbi.nlm.nih.gov/pubmed/15767291</a><br />
<br />
Based on our patten of inside and outside antigens is seems that the outer antigens would be collected by the B1 cells and processed by the MSC cells while the inner antigens would be taken up by the pericytes and shown to the myeloid derived stromal cells.</div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-10952873660711780102019-08-21T10:40:00.004-07:002019-09-07T09:18:07.385-07:00Chorioid Plexus compared to the BBB blood brain barrier<div dir="ltr" style="text-align: left;" trbidi="on">
Chorioid Plexus compared to the BBB blood brain barrier and the hypothesis that they deal with different antigens.<br />
<br />
<br />
Each of the brain's ventricles has their own CP region<br />
<br />
Capillary blood is filtered here at the CP to become cerebrospinal fluid.<br />
<br />
Resident macrophages and dendritic cells are in the CP<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496674/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496674/</a><br />
<br />
Note that resident macrophages come from the yolk and focus on outer antigens while travel monocytes come from bone marrow and develop into dendritic cells or macrophages that deal with inner antigens based on the hormone that they see. High insulin favors macrophages while IGF-1 or GH exposed monocytes develop into dendritic cells.<br />
<br />
IGF-1 made by CP epithelial<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/7513042">https://www.ncbi.nlm.nih.gov/pubmed/7513042</a><br />
<br />
this would favor dendritic over macrophages (traveling)<br />
<br />
myeloid dendritic cells of the cp<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/16817190">https://www.ncbi.nlm.nih.gov/pubmed/16817190</a><br />
<br />
CP : fibroblasts, macrophages, dendritic cells<br />
<a href="https://www.frontiersin.org/articles/10.3389/fncel.2015.00136/full">https://www.frontiersin.org/articles/10.3389/fncel.2015.00136/full</a><br />
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astrocytes (stromal cells) attract dendritic cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/16106219">https://www.ncbi.nlm.nih.gov/pubmed/16106219</a><br />
<br />
astrocytes activate B cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/29673365">https://www.ncbi.nlm.nih.gov/pubmed/29673365</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/26223505">https://www.ncbi.nlm.nih.gov/pubmed/26223505</a><br />
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pericytes and and astrocytes communication<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042982/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042982/</a><br />
<br />
FRC-like cells in CNS<br />
<a href="https://www.cell.com/immunity/pdfExtended/S1074-7613(16)30001-2">https://www.cell.com/immunity/pdfExtended/S1074-7613(16)30001-2</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com2tag:blogger.com,1999:blog-2399123431411408462.post-52930817305308632032019-08-19T09:54:00.002-07:002019-09-05T05:22:34.961-07:00At the intestine: inner antigens are processed at ILFs while outer antigens are processed in Peyer patches (hypothesis)<div dir="ltr" style="text-align: left;" trbidi="on">
<span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 15.9991px;">At the intestine: inner antigens are processed at ILFs while outer antigens are processed in Peyer patches.</span><br />
<span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 15.9991px;"><br /></span>
<span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 15.9991px;">ILF: inducible lymph follicle</span><br />
<span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 15.9991px;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/12759424">https://www.ncbi.nlm.nih.gov/pubmed/12759424</a></span><br />
<span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 15.9991px;"><br /></span>
<span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 15.9991px;">"In contrast to the spleen, LNs and PPs, ILFs are inducible structures developed after birth due to the presence of external stimuli</span><span style="background-color: white; font-family: "times new roman" , "stixgeneral" , serif; font-size: 0.8461em; line-height: 1.6363em; position: relative; top: -0.5em; vertical-align: baseline;"><a aria-expanded="false" aria-haspopup="true" class=" bibr popnode tag_hotlink tag_tooltip" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015111/#b43" id="__tag_556009286" rid="b43" role="button" style="color: #642a8f;">43</a>"</span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015111/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015111/</a><br />
<br />
The MRC marginal reticular cells develop here at the inducible ILF of the intestine.<br />
<br />
pericytes in the gut<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/30937864">https://www.ncbi.nlm.nih.gov/pubmed/30937864</a><br />
<br />
Peyer patches have the FRC fibroblast reticular cells.<br />
<br />
Brain macrophages : pericytes<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/10611494">https://www.ncbi.nlm.nih.gov/pubmed/10611494</a><br />
<br />
MHC2 expression by pericytes<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844098/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844098/</a><br />
<br />
pericytes and the BBB<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/</a><br />
<br />
peyer patch lacking mice had no IgA only IgG from ILFs<br />
<a href="https://www.jimmunol.org/content/jimmunol/173/2/762.full.pdf">https://www.jimmunol.org/content/jimmunol/173/2/762.full.pdf</a><br />
<br />
Remember the lymph structure and the separate zones for inner and outer antigens:<br />
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Then the spleen's separate zones:<br />
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Now looking for the MRC and the FRC we find very separate zones in the intestine:<br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-26035125350173747662019-07-27T11:46:00.000-07:002019-07-27T17:35:54.355-07:00Bee allergy, t.gondii, and the cells cytosol : I am not sure what I am looking at. <div dir="ltr" style="text-align: left;" trbidi="on">
cd16 is on Basophils of patients with insect venom allergy<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/30288810">https://www.ncbi.nlm.nih.gov/pubmed/30288810</a><br />
<br />
IgG2 and insect venom allergy<br />
<a href="https://link.springer.com/article/10.1007%2FBF00441707">https://link.springer.com/article/10.1007%2FBF00441707</a><br />
<br />
malaria and IgG2<br />
<a href="https://iai.asm.org/content/68/3/1252">https://iai.asm.org/content/68/3/1252</a><br />
<br />
t.cruzi and IgG2<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577053/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577053/</a><br />
<br />
malaria also infects the cytosol<br />
<a href="https://science.sciencemag.org/content/328/5980/862/F2">https://science.sciencemag.org/content/328/5980/862/F2</a><br />
<br />
old post about Bee allergy and T.gondii<br />
<a href="https://angelabiggs.blogspot.com/2015/04/tgondii-and-bee-venom.html">https://angelabiggs.blogspot.com/2015/04/tgondii-and-bee-venom.html</a><br />
<br />
T.gondii infects the cytosol. Previous hypothesis was that IgG2 is the antibody made against cytosol infections. I was sorting the Fc receptors with the IgGsubsets...when this occurred to me.<br />
<br />
These are not proven just appears to be a pattern<br />
cd16 (fcgammaRIII) binds IgG3 which is high on platelets? mito/nucl viruses<br />
cd16 (fcgammaRIV) binds IgG2b which is high on eosinophils? cytosol infection?<br />
cd64 (fcgammaRI) binds IgG2a cytosol virus?<br />
cd32 (fcgammaRII) binds IgG1 and is high on Langerhans? outer antigens<br />
<br />
Is this why the patients with insect allergy would have cd16?<br />
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<h3 class="post-title entry-title" itemprop="name" style="background-color: white; color: #333333; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 18px; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-weight: normal; line-height: normal; margin: 0px; position: relative;">
T.gondii and Bee venom</h3>
<div class="post-header" style="background-color: white; color: #999999; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 13.5px; line-height: 1.6; margin: 0px 0px 1.5em;">
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<div class="post-body entry-content" id="post-body-499711373915362920" itemprop="description articleBody" style="background-color: white; color: #333333; font-family: Georgia, Utopia, "Palatino Linotype", Palatino, serif; font-size: 14.85px; line-height: 1.4; position: relative; width: 578px;">
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<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">Do people with bee sting allergies have t.gondii infections?</span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">I have connected T.gondii with a variety of things: Seizures, Epilepsy, schizophrenia....but they are all autoimmune which means cross-targeting autoimmunity must be occurring. A virus has to trigger the attack at the target tissue from the inside. Are these autoimmune diseases all bee sensitive because of their connection to T.gondii?</span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">Schizophrenia: t.gondii and the cytomegavirus</span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><a href="http://www.sciencedaily.com/releases/2013/03/130308111315.htm" style="color: #6699cc; text-decoration-line: none;">http://www.sciencedaily.com/releases/2013/03/130308111315.htm</a></span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">Bee sting reactions have been found in schizophrenia patients</span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/5239954" style="color: #6699cc; text-decoration-line: none;">http://www.ncbi.nlm.nih.gov/pubmed/5239954</a></span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">I have connected in the past seizures/epilepsy with t.gondii and enteroviruses </span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><a href="http://angelabiggs.blogspot.com/2015/01/nodding-disease-epilepsy-seizuresare.html" style="color: #6699cc; text-decoration-line: none;">http://angelabiggs.blogspot.com/2015/01/nodding-disease-epilepsy-seizuresare.html</a></span><br />
<br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">Seizures and bee stings </span><br />
<span style="font-size: 13px; line-height: 17.9998px;"><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><a href="http://epilepsyfoundation.ning.com/group/support-for-cps/forum/topics/bee-stings-and-seizures?commentId=2217546%3AComment%3A908079&xg_source=activity&groupId=2217546%3AGroup%3A819391" style="color: #6699cc; text-decoration-line: none;">http://epilepsyfoundation.ning.com/group/support-for-cps/forum/topics/bee-stings-and-seizures?commentId=2217546%3AComment%3A908079&xg_source=activity&groupId=2217546%3AGroup%3A819391</a></span></span><br />
<span style="font-size: 13px; line-height: 17.9998px;"><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/22100477" style="color: #6699cc; text-decoration-line: none;">http://www.ncbi.nlm.nih.gov/pubmed/22100477</a></span></span><br />
<span style="font-size: 13px; line-height: 17.9998px;"><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><a href="http://www.japi.org/february_2012/11_cr_stroke_after_multiple.pdf" style="color: #6699cc; text-decoration-line: none;">http://www.japi.org/february_2012/11_cr_stroke_after_multiple.pdf</a></span></span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><span style="font-size: 13px; line-height: 17.9998px;">epilepsy and wasp stings</span></span><br />
<span style="font-size: 13px; line-height: 17.9998px;"><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8844507" style="color: #6699cc; text-decoration-line: none;">http://www.ncbi.nlm.nih.gov/pubmed/8844507</a></span></span><br />
<span style="font-size: 13px; line-height: 17.9998px;"><a href="http://jnnp.bmj.com/content/74/1/134.2.full" style="color: #6699cc; text-decoration-line: none;">http://jnnp.bmj.com/content/74/1/134.2.full</a></span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">Does Apis mellifera </span><span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">venom (honey bee venom) effect T.gondii?</span><br />
<span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">I can't see this paper to find out: </span><br />
<ul style="color: #444444; font-family: arial; font-size: 12px; line-height: 16px; list-style: none; margin: 0.5em 0px; padding: 0px 60px;">
<li style="border-bottom: 1px solid rgb(187, 230, 159); border-image: initial; border-left: 10px solid rgb(187, 230, 159); border-right: none; border-top: none; margin: 2px 0px; padding: 5px 1px 1px 4px;"><b><span lang="SL">Effect of Bee Venom on <i>Toxoplasma gondii</i> Tachyzoites <i>in vitro</i> - </span></b><b><span lang="SL">Ahmad G. Hegazi, Hassan A. El-Fadaly </span></b><span lang="SL">and<b> Ashraf M. BARAKAT (Egypt)</b></span></li>
</ul>
<span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">T.gondii is carried by mice and cats</span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><span style="font-size: 13px; line-height: 17.9998px;">T.cruzi is carried by kissing bugs and the dogs that eat them</span></span><br />
<span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span class="highlight" style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">T.cruzi which causes changas is killed by honey bee venom</span><br />
<span class="highlight" style="font-size: 13px; line-height: 17.9998px;"><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/23562368" style="color: #6699cc; text-decoration-line: none;">http://www.ncbi.nlm.nih.gov/pubmed/23562368</a></span></span><br />
<br />
The Kissing bug carries the T.cruzi the way mice carry T.gondii<br />
<span class="highlight" style="font-size: 13px; line-height: 17.9998px;"><a href="http://blog.mysanantonio.com/animals/2013/09/san-antonio-humane-society-says-chagas-disease-possible-in-local-dogs/" style="color: #6699cc; text-decoration-line: none;">http://blog.mysanantonio.com/animals/2013/09/san-antonio-humane-society-says-chagas-disease-possible-in-local-dogs/</a></span><br />
note that kissing bugs are nocturnal so keep your pet in at night<br />
<br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">Hymenoptera are the venom group of Apoidea (bees), Vespoidea (wasps, hornets, and yellow jackets), and Formicidae (ants). </span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><br /></span><span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;">What is it in the bee sting that Toxoplasmas dislike? perhaps the compound apamin which can cross the blood brain barrier. (our nerves don't like it either)</span><br />
<span style="font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 13px; line-height: 17.9998px;"><a href="http://pubs.acs.org/doi/abs/10.1021/bi00682a035" style="color: #6699cc; text-decoration-line: none;">http://pubs.acs.org/doi/abs/10.1021/bi00682a035</a></span><br />
<br />
Interestingly HoneyBee venom has been a remedy for malaria too.<br />
<br />
<span style="color: #3f3f3f; font-family: "helvetica neue" , "helvetica" , "arial" , sans-serif; font-size: 14px; line-height: 20px;">Panafrican News Agency (PANA). 17 September 1997. Yahya el Hassan. "Curing Malaria with Bee Stings in Sudan." [Internet]. </span><http: style="color: #3f3f3f; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; line-height: 20px;" www.africanews.org="">[Accessed 24 Dec. 1998].</http:><br />
<br />
<a href="https://books.google.com/books?id=JlSJDj5Lt98C&pg=PA153&lpg=PA153&dq=bee+stings+and+malaria&source=bl&ots=kXRWjUnlba&sig=Q7s5Av9JLOys_nMEi8I5pfzmRUg&hl=en&sa=X&ei=oeQlVZaHA8K1oQTxpoHACQ&ved=0CCkQ6AEwAg#v=onepage&q=bee%20stings%20and%20malaria&f=false" style="color: #6699cc; text-decoration-line: none;">https://books.google.com/books?id=JlSJDj5Lt98C&pg=PA153&lpg=PA153&dq=bee+stings+and+malaria&source=bl&ots=kXRWjUnlba&sig=Q7s5Av9JLOys_nMEi8I5pfzmRUg&hl=en&sa=X&ei=oeQlVZaHA8K1oQTxpoHACQ&ved=0CCkQ6AEwAg#v=onepage&q=bee%20stings%20and%20malaria&f=false</a></div>
</div>
</div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com2tag:blogger.com,1999:blog-2399123431411408462.post-67926797731818094162019-07-20T19:40:00.000-07:002019-07-31T14:24:50.181-07:00il-27, 25HC, and IgG2a against cytosol viral infections ?<div dir="ltr" style="text-align: left;" trbidi="on">
il-27 induces IgG2a from Bcells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/15294962">https://www.ncbi.nlm.nih.gov/pubmed/15294962</a><br />
<br />
il-27 induces 25hc<br />
<a href="https://www.researchgate.net/figure/IL-27-specifically-induces-cholesterol-25-hydroxylase-Ch25h-expression-and-25-OHC_fig1_320017159">https://www.researchgate.net/figure/IL-27-specifically-induces-cholesterol-25-hydroxylase-Ch25h-expression-and-25-OHC_fig1_320017159</a><br />
<br />
<a href="https://www.researchgate.net/publication/320017159_IL-27-Induced_Type_1_Regulatory_T-Cells_Produce_Oxysterols_that_Constrain_IL-10_Production">https://www.researchgate.net/publication/320017159_IL-27-Induced_Type_1_Regulatory_T-Cells_Produce_Oxysterols_that_Constrain_IL-10_Production</a><br />
<br />
25HC blocks viral entry<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/25501851">https://www.ncbi.nlm.nih.gov/pubmed/25501851</a><br />
<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=27086126">https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=27086126</a><br />
<br />
Does 25hc help create exosomes which then binds with dendritic cells and SCS lymph cells?<br />
<br />
cd169 binds 25HC to capture exosomes<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/24255917">https://www.ncbi.nlm.nih.gov/pubmed/24255917</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/29425504">https://www.ncbi.nlm.nih.gov/pubmed/29425504</a><br />
<br />
Complement and IgG2a<br />
<a href="https://www.jimmunol.org/content/178/1_Supplement/S159.5">https://www.jimmunol.org/content/178/1_Supplement/S159.5</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/6610105">https://www.ncbi.nlm.nih.gov/pubmed/6610105</a><br />
<br />
IgG2a and influenza<br />
<a href="https://cvi.asm.org/content/13/9/981">https://cvi.asm.org/content/13/9/981</a><br />
<br />
IgG2a with viruses and parasites?<br />
<a href="https://academic.oup.com/intimm/article/12/2/223/652665">https://academic.oup.com/intimm/article/12/2/223/652665</a><br />
<br />
Does 25hc hold viruses on the surface? how would complement work?<br />
<br /></div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-48443193004880300222019-07-19T12:54:00.001-07:002019-08-10T19:43:12.528-07:00Hypothesis: il-27 cytokine is secreted by B cells when there is a viral infection or cancer damage involving the cytosol of cells.<div dir="ltr" style="text-align: left;" trbidi="on">
Hypothesis: il-27 cytokine is secreted by B cells when there is a viral infection or cancer damage involving the cytosol of cells.<br />
<br />
p53 and il-27<br />
<a href="http://clincancerres.aacrjournals.org/content/clincanres/early/2016/05/27/1078-0432.CCR-15-2052.full.pdf">http://clincancerres.aacrjournals.org/content/clincanres/early/2016/05/27/1078-0432.CCR-15-2052.full.pdf</a><br />
<br />
Is il-27 involved with DNA damage?<br />
<br />
melanoma and il-27<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/18453571">https://www.ncbi.nlm.nih.gov/pubmed/18453571</a><br />
<br />
melanoma is a cancer caused by DNA damage (from sun exposure)<br />
<br />
<b>DNA damage and the cytosolic sensors</b><br />
<a href="http://jem.rupress.org/content/215/5/1287">http://jem.rupress.org/content/215/5/1287</a><br />
<br />
B cells major source of il-27<br />
<a href="https://www.jimmunol.org/content/200/1_Supplement/107.5">https://www.jimmunol.org/content/200/1_Supplement/107.5</a><br />
<br />
B cells produce IgG2a (class switch) after il-27<br />
<a href="https://www.jimmunol.org/content/173/4/2479.long?utm_source=TrendMD&utm_medium=cpc&utm_campaign=J_Immunol_TrendMD_0">https://www.jimmunol.org/content/173/4/2479.long?utm_source=TrendMD&utm_medium=cpc&utm_campaign=J_Immunol_TrendMD_0</a><br />
<br />
IgG2a against reoviruses and parasites<br />
<a href="https://academic.oup.com/intimm/article/12/2/223/652665">https://academic.oup.com/intimm/article/12/2/223/652665</a><br />
<br />
il-27 attracts myeloid dendritic cells to the lymph<br />
<a href="https://www.jimmunol.org/content/192/6/2634">https://www.jimmunol.org/content/192/6/2634</a><br />
<br />
previous hypothesis:<br />
myeloid dendritic cells are involved with infections of the cytosol<br />
plasmacytoid dendritic cells are involved with infection of the mitochondria/ nucleus<br />
<br />
il-27 not il-35 suppresses gm-csf<br />
<a href="https://www.nature.com/articles/s41598-017-16702-w">https://www.nature.com/articles/s41598-017-16702-w</a><br />
<br />
<br />
<b>GM-csf is involved with vacuole bacteria and TH17 triggering</b><br />
<br />
GM-csf exposed Basophil's produce il-6 and trigger th17<br />
<a href="https://www.nature.com/articles/srep41744">https://www.nature.com/articles/srep41744</a><br />
<br />
GM-csf exposed mDendritic make il-23<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297527/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297527/</a><br />
<br />
As a cytosol infection TH1 is involved<br />
<a href="https://www.nature.com/articles/7310017?error=server_error">https://www.nature.com/articles/7310017?error=server_error</a><br />
<br />
il-27 is saying it is in the cytosol..what ever it is...not a bacteria hiding in the cytosol or in a virus in the nucleus or mitochondria.<br />
<br />
<b>Furthermore</b><br />
<b><br /></b>
il-27 suppressed il-5 and il-13 from TH2 cells which is used against parasites in the cytosol. Which means il-27 could be strictly a cytokine for viruses or for DNA from cancer in the cytosol?<br />
<br />
<a href="https://www.jimmunol.org/content/179/7/4415">https://www.jimmunol.org/content/179/7/4415</a><br />
<br />
When does the B cell decide to make il-27? Does the T follicular cell recognize it as DNA and signal back to the B cell?<br />
<br />
<br />
<br />
<br />
<br /></div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-21045729553899266882019-07-13T08:58:00.001-07:002019-07-13T09:02:27.573-07:00IgG2, cytosol infections, and the lectin pathway. <div dir="ltr" style="text-align: left;" trbidi="on">
Complement activation and Antibodies<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/20151159">https://www.ncbi.nlm.nih.gov/pubmed/20151159</a><br />
<br />
Classical pathway: IgG1 and IgG3<br />
<br />
Alternative and lectin: IgG2 and IgG4<br />
<br />
LPS triggers the TLR4 or the lectin-mannose complement activation. These tend to be the type of infections that can move inside of cells. Some infections move into the vacuoles and organelles others the cytosol.<br />
<br />
Strep has even been shown to move inside of cells allowing the bacteria to survive antibiotics. <a href="https://www.ncbi.nlm.nih.gov/books/NBK333420/">https://www.ncbi.nlm.nih.gov/books/NBK333420/</a><br />
<br />
basophils as APC to TH2 inducing il-13<br />
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201040588">https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201040588</a><br />
<br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjW98R1ng_im2qt8um2yT12lfVsyldyxJEEg4rSpjjawwu5p8IXpTe9OzYAWECd9XaZrXIB4YLXXrnK1jy2UvGv_9XNd54NgcjrgumMS_VePD1tYuWIC4h1RYi4mk1QZRuXDD77aOhebcA/s1600/IMG_20190713_095536.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjW98R1ng_im2qt8um2yT12lfVsyldyxJEEg4rSpjjawwu5p8IXpTe9OzYAWECd9XaZrXIB4YLXXrnK1jy2UvGv_9XNd54NgcjrgumMS_VePD1tYuWIC4h1RYi4mk1QZRuXDD77aOhebcA/s640/IMG_20190713_095536.jpg" width="480" /></a></div>
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-48580216341898491832019-07-12T14:17:00.001-07:002019-07-12T14:17:26.995-07:00IgG2, GSDMD, and cytosol infections<div dir="ltr" style="text-align: left;" trbidi="on">
Hypothesis: GSDM pores are windows for eosinophils<br />
<br />
Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?<br />
<br />
il-13 and IgG2 production by B cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/10415009">https://www.ncbi.nlm.nih.gov/pubmed/10415009</a><br />
<br />
High IgG2 and <em style="background-color: white; font-family: "Times New Roman", stixgeneral, serif; font-size: 15.9991px;">Cryptococcus neoformans</em><span style="background-color: white; font-family: "Times New Roman", stixgeneral, serif; font-size: 15.9991px;"> </span><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828574/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828574/</a><br />
<br />
<em style="background-color: white; font-family: "Times New Roman", stixgeneral, serif; font-size: 15.9991px;">Cryptococcus neoformans</em><span style="background-color: white; font-family: "Times New Roman", stixgeneral, serif; font-size: 15.9991px;"> </span>inside macrophages<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127716/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127716/</a><br />
<br />
il-13 and C. neoformans<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/17911623">https://www.ncbi.nlm.nih.gov/pubmed/17911623</a><br />
<br />
Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?<br />
<br />
<b>IgE</b> at the skin's <b>IGF-1</b> with the GSDMA pore<br />
<b>IgA </b>, <b>GH</b> with GSDMB<br />
<b>IgG1</b>, <b>insulin </b>with GSDMC<br />
<br />
IgG2 with GSDMD...<b>all areas involving cytosol infections</b><br />
<br />
High IgG2 and <em style="background-color: #eff2f7; border: 0px; box-sizing: border-box; color: #2a2a2a; font-family: Merriweather, serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Plasmodium</em><br />
<a href="https://iai.asm.org/content/iai/68/3/1252.full.pdf">https://iai.asm.org/content/iai/68/3/1252.full.pdf</a><br />
<br />
<em style="background-color: #eff2f7; border: 0px; box-sizing: border-box; color: #2a2a2a; font-family: Merriweather, serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Plasmodium </em>are inside erythrocytes<br />
<a href="https://academic.oup.com/femsre/article/40/5/701/2198099">https://academic.oup.com/femsre/article/40/5/701/2198099</a><br />
<br />
eosinophils and plasmodium (malaria parasite)<br />
<br />
mycobacteria and cytosol<br />
<a href="https://academic.oup.com/femsre/article/43/4/341/5420823">https://academic.oup.com/femsre/article/43/4/341/5420823</a><br />
<br />
mycobacteria and IgG2<br />
<a href="https://gh.bmj.com/content/4/Suppl_3/A31.2">https://gh.bmj.com/content/4/Suppl_3/A31.2</a><br />
<br />
mycobacteria and GSDMD<br />
<a href="https://www.biorxiv.org/content/biorxiv/early/2019/02/17/514125.full.pdf">https://www.biorxiv.org/content/biorxiv/early/2019/02/17/514125.full.pdf</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-32545708609019886132019-07-01T10:47:00.000-07:002019-08-17T10:22:31.923-07:00Stromal cells produce cxcl13 attracting B cells and they have 3 areas of importance <div dir="ltr" style="text-align: left;" trbidi="on">
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Stromal cells produce cxcl13 attracting B cells and they have 3 areas of importance: two stromal cells in the lymph node ; one area is for internal antigens and the other area is for outer antigens. The third stromal cell area is for catching infections that have escaped the gut's organs in the omentum zone.<br />
<br />
adipose stromal cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481843/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481843/</a><br />
<br />
omentum milky fat spots have adipose stromal cells (ASC) which produce the CXCL13<br />
the B1 cells involved there are the primary source of IgM<br />
<a href="https://www.researchgate.net/publication/265860846_Human_adipose_tissue-derived_mesenchymal_stromal_cells_promote_B-cell_motility_and_chemoattraction">https://www.researchgate.net/publication/265860846_Human_adipose_tissue-derived_mesenchymal_stromal_cells_promote_B-cell_motility_and_chemoattraction</a><br />
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Marginal Reticular cells MRC are mesenchymal stromal cells of the scs area<br />
<br />
Fibroblastic Reticular cells FRC are bundled into the conduit leading to the follicular dendritic cells<br />
<br />
All 3 of these stromal subsets make cxcl13 which attract B cells and follicular T cells thus creating the germinal centers<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/28454789">https://www.ncbi.nlm.nih.gov/pubmed/28454789</a><br />
<br />
The MRC-SCS zone creates antibodies against the inner antigens (IgG2 or IgG3) while the FRC-FDC zone creates the antigens against the outer antigens. (IgG1 at the spleen, IgE at the lymph, and IgA dimers in peyer patches.) The milky spots with the ASC attract the B1 cells thus producing IgM.<br />
<br />
MRC was thought to transport antigens from SCS to FDC which could be the differentiation of MRC into FDC of inner antigens.<br />
<a href="http://jem.rupress.org/content/211/6/1109">http://jem.rupress.org/content/211/6/1109</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=jem.20132409">https://www.ncbi.nlm.nih.gov/pubmed/?term=jem.20132409</a><br />
<br />
Does SCS not present to B cells directly rather hands the antigen to MRC who presents?<br />
<br />
Here is a paper that has the SCS handing off to a nonphagocytic cell they call ATC (antigen transporting cell ) that appears to mature into a FDC type of cell<br />
<a href="https://www.jimmunol.org/content/131/4/1714.long">https://www.jimmunol.org/content/131/4/1714.long</a><br />
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MRC as phagocyte of apoptotic B cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/29686051">https://www.ncbi.nlm.nih.gov/pubmed/29686051</a><br />
<br />
Is this incase the B cells are infected?<br />
<br />
the conduit transports soluble antigens<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/15664156">https://www.ncbi.nlm.nih.gov/pubmed/15664156</a><br />
<br />
Langerhans bring antigen through conduit<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/16818784">https://www.ncbi.nlm.nih.gov/pubmed/16818784</a><br />
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exosomes derived from dendritic cells migrate to spleen<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320445/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320445/</a><br />
<br />
cd169 mediates the capture of exosomes<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/24255917">https://www.ncbi.nlm.nih.gov/pubmed/24255917</a><br />
<br />
25hc and viral infections<br />
<a href="https://www.nature.com/articles/nri3755/figures/4">https://www.nature.com/articles/nri3755/figures/4</a><br />
<br />
immature exosomes teach tolerance while mature dendritic cell exosomes induce immune reaction<br />
<a href="https://link.springer.com/article/10.1007/s10753-012-9539-1">https://link.springer.com/article/10.1007/s10753-012-9539-1</a><br />
<br />
scs and viral infection of the central nervous system<br />
<a href="https://www.nature.com/articles/nature09118">https://www.nature.com/articles/nature09118</a><br />
<a href="https://link.springer.com/article/10.1007/s10753-012-9539-1"><br /></a>
<a href="https://link.springer.com/article/10.1007/s10753-012-9539-1"><br /></a>
<a href="https://link.springer.com/article/10.1007/s10753-012-9539-1"><br /></a>
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com1tag:blogger.com,1999:blog-2399123431411408462.post-60414745611347757172019-07-01T10:29:00.003-07:002019-07-01T10:29:41.501-07:00Behcet's disease is autoimmune cross-targeting of strep and HSV1 update<div dir="ltr" style="text-align: left;" trbidi="on">
Behcet's disease is autoimmune cross-targeting of strep and HSV1<br />
<br />
Behcets has anti-cardiolipin and is associated with strep<br />
<a href="http://angelabiggs.blogspot.com/2013/04/behcets-disease.html">http://angelabiggs.blogspot.com/2013/04/behcets-disease.html</a><br />
<br />
Behcets and mitochondria polymorphisms<br />
<a href="https://acrabstracts.org/abstract/genetic-association-of-mitochondrial-dna-polymorphisms-with-behcets-disease-in-a-korean-population/">https://acrabstracts.org/abstract/genetic-association-of-mitochondrial-dna-polymorphisms-with-behcets-disease-in-a-korean-population/</a><br />
<br />
HLA-B5, Behcets and autoimmune disease<br />
<a href="https://acrabstracts.org/abstract/hla-b51-and-possible-associated-autoimmune-disorders-other-than-behcets-disease-a-retrospective-cohort-study/">https://acrabstracts.org/abstract/hla-b51-and-possible-associated-autoimmune-disorders-other-than-behcets-disease-a-retrospective-cohort-study/</a><br />
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HLA-B is the t cell mailbox for mitochondrial infections which HSV-1 is<br />
<br />
Behcet's and herpes simplex 1<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857840/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857840/</a><br />
<br />
erythema nodosum and behcets<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/22504656">https://www.ncbi.nlm.nih.gov/pubmed/22504656</a><br />
<br />
TLR9 and behcet's<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/23237868">https://www.ncbi.nlm.nih.gov/pubmed/23237868</a><br />
<br />
TLR9 is the butterfly net for mitochondria infections. When triggered it causes the expression of HLA-b and IFNalpha<br />
<br />
Behcets has anti-cardiolipin and is associated with strep<br />
<a href="http://angelabiggs.blogspot.com/2013/04/behcets-disease.html">http://angelabiggs.blogspot.com/2013/04/behcets-disease.html</a><br />
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Behcet's Disease is it a cross-targeting autoimmune disease?</h3>
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The autoimmune hypothesis pattern: an infection first inducing antibodies followed by a viral infection which causes cross-targeting thus triggering the immune system to attack causing autoimmune disease.<span> </span><br /><br />For Behcet's disease the infection culprits are Streptococcus sanguinis and herpes simplex (mouth ulcers)<br /><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/23137016" style="color: #6699cc; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/23137016</a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/18693149" style="color: #6699cc; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/18693149<span> </span></a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/21052488" style="color: #6699cc; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/21052488</a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/22204815" style="color: #6699cc; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/22204815</a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/22766172" style="color: #6699cc; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/22766172</a><br /><br /><br />I found a strange overlap with MS and Behcet's.<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/12645628" style="color: #6699cc; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/12645628</a><span> </span><br /><br />For MS I have as psoriasis or eczema with herpes zoster triggering the autoimmune disease. <span> </span><br /><br />Could this be an entirely different type of MS? Where the strep has opened the blood brain barrier and the herpes virus is there? Is this actually a form of Alzheimer's? Where the herpes simplex virus is destroying the mitochondria? Or do I need to become much more specific with the herpes viruses? That could be the case. <span> </span><br /><br />Balo was/is a different type of MS where the virus is a hepatitis C virus and causing the ring shaped lesions. Balo is really a distinct autoimmune disease from MS. </div>
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-62506836350906413352019-06-05T10:37:00.002-07:002019-06-20T09:20:43.913-07:00NK and B cells in the lymph with il-15 or il-18<div dir="ltr" style="text-align: left;" trbidi="on">
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Previously hypothesis of how the lymph is organized in this sketich, so how does nk fit in?</div>
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<br />
<br />
il-18 and neutrophil activation<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/11509635">https://www.ncbi.nlm.nih.gov/pubmed/11509635</a><br />
<br />
il-18 and nk activation<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154249/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154249/</a><br />
<br />
il-18 listeria<br />
<a href="https://www.gastrojournal.org/article/S0016-5085(09)63232-7/abstract">https://www.gastrojournal.org/article/S0016-5085(09)63232-7/abstract</a><br />
<br />
listeria and golgi/ER<br />
<a href="http://www.jimmunol.org/content/jimmunol/168/7/3428.full.pdf">http://www.jimmunol.org/content/jimmunol/168/7/3428.full.pdf</a><br />
<br />
il-15 and nk<br />
<a href="https://www.pnas.org/content/101/47/16606">https://www.pnas.org/content/101/47/16606</a><br />
<br />
il-15 receptor and mantle B cells<br />
<a href="http://www.jimmunol.org/content/171/2/569">http://www.jimmunol.org/content/171/2/569</a><br />
<br />
RSV and il-15<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/17158609">https://www.ncbi.nlm.nih.gov/pubmed/17158609</a><br />
<br />
il-15 tells the nk there is a viral infection of the ER and the golgi<br />
<br />
il-18 tells the nk there is a bacterial infection of the ER and the golgi<br />
<br />
il-15 receptors are on the mantle B cells<br />
<br />
il-18 receptors are on the GC B cells<br />
<br />
il-18 secreted by dendritic cells and macrophages<br />
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2013.00289/full">https://www.frontiersin.org/articles/10.3389/fimmu.2013.00289/full</a><br />
<br />
il-15 secreted by monocytes and macrophages<br />
<br />
mycoplasmas and RA<br />
<a href="https://academic.oup.com/rheumatology/article/44/7/912/1788375">https://academic.oup.com/rheumatology/article/44/7/912/1788375</a><br />
<br />
mycoplasmas and ER<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/4844719">https://www.ncbi.nlm.nih.gov/pubmed/4844719</a><br />
<br />
ANA antibodies<br />
<a href="https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANA">https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANA</a><br />
<br />
listeria associated arthritis<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1153789/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1153789/</a><br />
<br />
<b>Is autoantibody IgG4 created when the B cell saw il-18 in the GC area first but then moved to the mantle when exposed to a virus?</b><br />
<b><br /></b>
<b>Note that the receptor on the B cell matches up with bacterial vs. viral.</b><br />
<b><br /></b>
il-15 activated NK can help against HIV<br />
<a href="https://jvi.asm.org/content/92/12/e00235-18">https://jvi.asm.org/content/92/12/e00235-18</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com1tag:blogger.com,1999:blog-2399123431411408462.post-69706178427193612432019-05-21T11:47:00.001-07:002020-05-23T13:51:23.219-07:00IgG4 antibodies<div dir="ltr" style="text-align: left;" trbidi="on">
Autoimmune hypothesis: Two infections on one target triggers autoimmune disease. One infection inside and one infection outside of the cell.<br />
<b><br /></b>
<b>Does the B cell that gets pulled from outside antigen pathways to inside antigen pathways become the IgG4 producing B cell with the goal of shutting down the outside pathways?</b><br />
<b><br /></b>
This would mean that the IgG4 would be similar based on the large infection and the pathway stopped if the autoimmune diseases share the same large infection. For example, all mycobacteria triggered autoimmune diseases would have the same IgG4 against aquaporins.<br />
<br />
<b>IgG4 antibodies represent a down-regulatory response</b><br />
<b><a href="https://www.ncbi.nlm.nih.gov/pubmed?term=24111912">https://www.ncbi.nlm.nih.gov/pubmed?term=24111912</a></b><br />
<b><br /></b>
<b>IgG4 made by Bcells that produce il-10</b><br />
<a href="https://www.jacionline.org/article/S0091-6749(13)00150-4/pdf">https://www.jacionline.org/article/S0091-6749(13)00150-4/pdf</a><br />
<br />
Br1 up regulate the plasma cells to become IgG4 producing<br />
<a href="https://www.jacionline.org/article/S0091-6749(16)30722-9/pdf">https://www.jacionline.org/article/S0091-6749(16)30722-9/pdf</a><br />
<br />
<br />
<b>Anti-Aquaporin</b><br />
<b><br /></b>
Mycobacteria and other bacterial cytosol infection which involve eosinophils and macrophages in a phagocytosis method appear to develop anti-AQP ( aquaporin antibodies)<br />
<br />
aquaporins move eosoinophils<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/18510218">https://www.ncbi.nlm.nih.gov/pubmed/18510218</a><br />
<br />
anti-aquaporin4 and multiple sclerosis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/20705110">https://www.ncbi.nlm.nih.gov/pubmed/20705110</a><br />
<br />
mycobacteria and multiple sclerosis<br />
<a href="https://www.sciencedaily.com/releases/2010/02/100226084007.htm">https://www.sciencedaily.com/releases/2010/02/100226084007.htm</a><br />
<br />
idiopathic demyelination and anti-AQP4<br />
<a href="https://www.hindawi.com/journals/msi/2017/1359761/">https://www.hindawi.com/journals/msi/2017/1359761/</a><br />
<br />
anti-aquaporin4 in neuromyelitis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/18808744">https://www.ncbi.nlm.nih.gov/pubmed/18808744</a><br />
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salivary glands and parkinson's disease<br />
<a href="https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=838">https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=838</a><br />
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salivary gland and psoriasis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/7165375">https://www.ncbi.nlm.nih.gov/pubmed/7165375</a><br />
<br />
salivary glands and aquaporins<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783900/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783900/</a><br />
<br />
parkinson's and mycobacteria<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/25459140">https://www.ncbi.nlm.nih.gov/pubmed/25459140</a><br />
<br />
psoriasis and mycobacteria<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/9657322">https://www.ncbi.nlm.nih.gov/pubmed/9657322</a><br />
<br />
aquaporin and psoriasis<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/21400035">https://www.ncbi.nlm.nih.gov/pubmed/21400035</a><br />
<br />
(Candida also has portions move to the cytosol)<br />
<br />
SJ and salivary<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/1055974">https://www.ncbi.nlm.nih.gov/pubmed/1055974</a><br />
<br />
Candida and SJ<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/12973284">https://www.ncbi.nlm.nih.gov/pubmed/12973284</a><br />
<br />
SJ and MS because of salivary<br />
<a href="https://www.jwatch.org/jn200112200000006/2001/12/20/possible-association-between-sjogrens-syndrome">https://www.jwatch.org/jn200112200000006/2001/12/20/possible-association-between-sjogrens-syndrome</a><br />
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<br />
<b>Anti-insulin</b><br />
<br />
Type one diabetes : coxsackie/flu and e.coli<br />
<br />
Neutrophils kill e.coli. How are these connected to insulin?<br />
<br />
neutrophils suppress insulin signalling ( enzyme secreted disrupts the receptor)<br />
<a href="https://stke.sciencemag.org/content/5/243/ec250">https://stke.sciencemag.org/content/5/243/ec250</a><br />
<br />
Insulin seems to be required for the functioning of neutrophils.<br />
<a href="https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.0104050">https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.0104050</a><br />
<br />
Does anti-growth hormone match up with celiac disease and anti-IGF-1 match up with alopecia? Is the IgG4 trying to stop the outer antigen pathway?<br />
<br />
celiac and Growth hormone deficiency<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570481/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570481/</a><br />
<br />
alopecia and IGF-1 deficiency<br />
<a href="https://www.sciencedirect.com/science/article/pii/S1087002415305372">https://www.sciencedirect.com/science/article/pii/S1087002415305372</a><br />
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Does it always switch to il-10 and no IFN when B switches places or is it like this?<br />
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<br />
<br />
<b>Anti-gangliosides</b><br />
<b><br /></b>
Involves vacuole bacteria<br />
<b><br /></b>
Guillian-barre and anti-gangliosides<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422685/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422685/</a><br />
<br />
<a href="http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=5;spage=1324;epage=1331;aulast=Baskar">http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=5;spage=1324;epage=1331;aulast=Baskar</a><br />
<br />
<a href="https://www.researchgate.net/publication/325884578_Anti-ganglioside_Antibodies_in_Peripheral_Nerve_Pathology">https://www.researchgate.net/publication/325884578_Anti-ganglioside_Antibodies_in_Peripheral_Nerve_Pathology</a><br />
<br />
natural killer cells<br />
<br />
il-15 and gangliosides<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/16116192">https://www.ncbi.nlm.nih.gov/pubmed/16116192</a><br />
<br />
gangliosides in autism<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/9766735">https://www.ncbi.nlm.nih.gov/pubmed/9766735</a><br />
<br />
sutterella and autism spectrum disorder<br />
<a href="https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-4-42">https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-4-42</a><br />
<br />
<br />
<b>Anti-ANCA / anti-ANA</b><br />
<b><br /></b>
involves golgi/ER b<b>acterias</b><br />
<br />
salmonella and anti-ANCA<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905360/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905360/</a><br />
<br />
reactive arthritis and salmonella<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195798/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195798/</a><br />
<br />
anti-ANCA bind the neutrophil traps<br />
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2017.00439/full">https://www.frontiersin.org/articles/10.3389/fimmu.2017.00439/full</a><br />
<br />
Anti-ANCA and Rheumatoid<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552688/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552688/</a><br />
<br />
anti-nuclear in strep with tourettes<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/12699862">https://www.ncbi.nlm.nih.gov/pubmed/12699862</a><br />
<br />
TLR8 and strep<br />
<a href="http://www.jimmunol.org/content/195/3/1092">http://www.jimmunol.org/content/195/3/1092</a><br />
<br />
TLR8 is the Tcell mailbox for the Endoplasmic reticulum<br />
<br />
polyarthritis and strep<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803937/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803937/</a><br />
<br />
<b><br /></b><b>Anti-leiomodin</b><br />
<br />
Nodding disease is triggered by the parasitic worm and what virus? The IgG4 was found against leiomodin-1. Nodding disease is autoimmune disease of the skin where the autoantigen attacks the brain?<br />
<br />
Autoimmune cross-targeting hypothesis: two infections on one tissue. The reaction is at the skin but then the antibody attacks the brain?<br />
<br />
For these worms how does this work? The Leiomodin-1 antibody bound the worms...but they were IgG4?<br />
<br />
When exposed to cold temperatures or food the children nod their heads uncontrollably. The hippocampus of the brain is responsible for body temperature sensations and hunger urges.<br />
<br />
The worm is not in the hippocampus but the autoantibody shows up there.<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/28202777">https://www.ncbi.nlm.nih.gov/pubmed/28202777</a><br />
<br />
Which virus at the skin has co-infected and caused the IgG4?<br />
<br />
Does this mean that leiomodin-1 is involved with eosinophils degranulation attack? Since eosinophils at the main cell type attacking the worms how would this work?<br />
<br class="Apple-interchange-newline" />
eosinophils and smooth muscles<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/23180361">https://www.ncbi.nlm.nih.gov/pubmed/23180361</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-57453183445902431792019-05-19T16:15:00.002-07:002019-05-19T16:15:47.237-07:00The autoimmune hypothesis and BR1<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgR9Cj00TnOIJLskNKTVSttENBA08fFxvZfR9aeyA4pfHfugUsOq4QnxwiGkx0sX_R_0xuL4sDCtcQ_6bDzOZUWLVeFXL-4o7t0FAcTGUqmtIpN7fl1bfqEb3hd995p30ZdjnVF7VCmleM/s1600/IMG_20190519_170454.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgR9Cj00TnOIJLskNKTVSttENBA08fFxvZfR9aeyA4pfHfugUsOq4QnxwiGkx0sX_R_0xuL4sDCtcQ_6bDzOZUWLVeFXL-4o7t0FAcTGUqmtIpN7fl1bfqEb3hd995p30ZdjnVF7VCmleM/s640/IMG_20190519_170454.jpg" width="480" /></a></div>
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-68167453261289236892019-05-13T12:23:00.002-07:002019-05-14T10:19:05.474-07:00B regulatory cells<div dir="ltr" style="text-align: left;" trbidi="on">
There are 3 types of B regulatory cells (all with CD38 like T regs)<br />
<br />
The ones created from naive B cells, possibly in the bloodstream could be involved in cancer.<br />
These B regs secrete TGF-b1 and il-10 focusing the reaction on CTL pathways. Nuclear viral infections have been connected to cancer.<br />
<br />
Bregs and cancer<br />
<a href="https://www.hindawi.com/journals/jir/2014/215471/">https://www.hindawi.com/journals/jir/2014/215471/</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891151/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891151/</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549607/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549607/</a><br />
<br />
I suspect il-9 involvement with these B regulatory cells but I have found no evidence yet.<br />
<br />
The ones created from marginal zone B cells with IgM BCRs may focus the immune system like natural T regs. These Bregs secrete il-10 and il-35 focusing the reaction on outer antigens. (do they have cd27+ because of the IgM?)<br />
<br />
il-33 activates B1 and marginal zone B cells<br />
<a href="http://www.jimmunol.org/content/186/4/2584">http://www.jimmunol.org/content/186/4/2584</a><br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012142/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012142/</a><br />
<br />
il-33 is released by cells during necrosis (cells damaged and dying). il-33 also stimulates Th2 pathway cells like: eosinophils mast cells, and basophils. This makes sense in that when the tissue is damaged, like a cut, there is a risk of infection.<br />
<br />
The ones created from cd27+ plasma cells in the germinal center region which stops the reactions similar to inducible T regs. <br />
<br />
il-35 Bregs<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433835/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433835/</a><br />
<br />
Hypothesis:<br />
il-10 stops TH1 pathways (cytosol antigen)<br />
il-35 stops CTL pathways (nuclear or mito antigen)<br />
TGF-b1 stops TH2 pathways (outer antigen)<br />
<br />
Corrected...some how I had this mixed up<br />
<br />
<br /></div>
Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-47569228189459116672019-05-07T08:02:00.001-07:002019-05-07T19:40:44.938-07:00Exosomes, internal antigens, dendritic cells, and the lymph<div dir="ltr" style="text-align: left;" trbidi="on">
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How do myeloid and plasmacytoid dendritic cells get viral antigens from inside infected cells? From exosomes? </div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjifXk3VxMf4_rS9gRXZC6LhAXHRpV34aTBm69RqJe1b_iL8hGZUzxqOkcP7FMDzq_yprhqqX-oDKoIvuHatPb7WKfd1ZAacRH9vulSN3UTcyCrtrP7c_XCgFEiIwqBMiTA8Ym3YqjO9Gg/s1600/IMG_20190507_082718.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjifXk3VxMf4_rS9gRXZC6LhAXHRpV34aTBm69RqJe1b_iL8hGZUzxqOkcP7FMDzq_yprhqqX-oDKoIvuHatPb7WKfd1ZAacRH9vulSN3UTcyCrtrP7c_XCgFEiIwqBMiTA8Ym3YqjO9Gg/s640/IMG_20190507_082718.jpg" width="480" /></a></div>
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What about viruses that infect the nucleus or the mitochondria?</div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjAe-Su9V1YOZwXL6qgrnLViyGscraKvo3_BxVVlbYyZbUNcCoqApJwM4h3NoXiHNbyqB5-t812QZPmjWC5B6CzVgu8ORM5pfEFuxeKRQwtFv3Y8MS6HAUbqce7u4nPi4kerDk7fYSCzvE/s1600/IMG_20190507_082849.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjAe-Su9V1YOZwXL6qgrnLViyGscraKvo3_BxVVlbYyZbUNcCoqApJwM4h3NoXiHNbyqB5-t812QZPmjWC5B6CzVgu8ORM5pfEFuxeKRQwtFv3Y8MS6HAUbqce7u4nPi4kerDk7fYSCzvE/s640/IMG_20190507_082849.jpg" width="480" /></a></div>
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Cells infected with mitochondrial virus HCV secrete exosomes</div>
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<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479672/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479672/</a></div>
<br />
When entering the lymph node the exosomes get absorbed by the SCS while larger antigens move down the conduit? how does that work?<br />
<br />
Langerhans has the ability to pull through collagen fibers<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/1431200">https://www.ncbi.nlm.nih.gov/pubmed/1431200</a><br />
<br />
Marginal zone B cells and pulling through collagen<br />
<a href="https://www.cell.com/immunity/supplemental/S1074-7613(05)00339-0">https://www.cell.com/immunity/supplemental/S1074-7613(05)00339-0</a><br />
<br />
The conduits in the lymph node/spleen are a network formed by collagen fibers<br />
<br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiBng2Z5Mu_YZkLSlq21lss8xrvOg2bGgnItO6p9EnbpxABixucjTycZTHwb1RiVtz8eaAHBVSNOiX59g9poknYSUruvaimXDLzJr_CNxeJa7WfWYeAmrfKqxgCeI1moCBYOCaT1LzyLw/s1600/IMG_20190507_092950.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiBng2Z5Mu_YZkLSlq21lss8xrvOg2bGgnItO6p9EnbpxABixucjTycZTHwb1RiVtz8eaAHBVSNOiX59g9poknYSUruvaimXDLzJr_CNxeJa7WfWYeAmrfKqxgCeI1moCBYOCaT1LzyLw/s640/IMG_20190507_092950.jpg" width="480" /></a></div>
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<br />
mDendritic and pDendritic squeeze between the scs cells using "dock8"<br />
<a href="http://www.bloodjournal.org/content/119/19/4451?sso-checked=true">http://www.bloodjournal.org/content/119/19/4451?sso-checked=true</a><br />
fantastic images<br />
<br />
Are exosomes blocked from conduit travel?<br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-43413387174268832272019-05-06T08:55:00.001-07:002019-05-29T13:29:46.583-07:00Update on influenza infections<div dir="ltr" style="text-align: left;" trbidi="on">
Update on influenza infections<br />
<br />
Hypothesis:<br />
<br />
Type A infects the cytosol and then the nucleus<br />
Type B and C infect the cytosol<br />
<br />
flu ssRNA and pDC/TLR7<br />
<a href="http://europepmc.org/articles/PMC4104278/">http://europepmc.org/articles/PMC4104278/</a><br />
<br />
Shows flu going into cytosol and then the nucleus<br />
<a href="http://www.virology.ws/2009/05/06/release-of-influenza-viral-rnas-into-cells/">http://www.virology.ws/2009/05/06/release-of-influenza-viral-rnas-into-cells/</a><br />
<br />
influenza A in the nucleus and the cytosol<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814596/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814596/</a><br />
<br />
th17 and influenza A<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/19265125">https://www.ncbi.nlm.nih.gov/pubmed/19265125</a><br />
<br />
type A goes to the mitochondria?<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715299/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715299/</a><br />
<br />
type A and B enter the cell differently<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/22855501">https://www.ncbi.nlm.nih.gov/pubmed/22855501</a><br />
<br />
only the D2 receptor altered mitochondria movement ?<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467486/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467486/</a><br />
<br />
Previous post:<br />
<br />
Hypothesis: Virus families use receptor families. The flu viruses use dopamine receptors.<br />
<br />
type A D2<br />
<br />
type B D1<br />
<br />
type C D5<br />
<br />
<br />
<div style="background-color: white; color: #333333; font-family: georgia, utopia, "palatino linotype", palatino, serif; font-size: 14.85px;">
D2 receptors are expressed on the pancreas</div>
<div style="background-color: white; color: #333333; font-family: georgia, utopia, "palatino linotype", palatino, serif; font-size: 14.85px;">
<a href="http://www.jbc.org/content/280/44/36824.long" style="color: #6699cc;">http://www.jbc.org/content/280/44/36824.long</a></div>
<div style="background-color: white; color: #333333; font-family: georgia, utopia, "palatino linotype", palatino, serif; font-size: 14.85px;">
<br /></div>
<div style="background-color: white; color: #333333; font-family: georgia, utopia, "palatino linotype", palatino, serif; font-size: 14.85px;">
Type A flu viruses appear to infect pancreatic cells</div>
<div style="background-color: white; color: #333333; font-family: georgia, utopia, "palatino linotype", palatino, serif; font-size: 14.85px;">
<a href="http://jvi.asm.org/content/87/1/597.full" style="color: #6699cc;">http://jvi.asm.org/content/87/1/597.full</a><br />
<br /></div>
Type B influenza have produced rashes<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280815/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280815/</a><br />
<a href="https://www.researchgate.net/publication/259984175_Rash_associated_with_influenza_B_virus_infection">https://www.researchgate.net/publication/259984175_Rash_associated_with_influenza_B_virus_infection</a><br />
<br />
Dopamine 1 receptors are in the dermal skin layer<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/23241131">https://www.ncbi.nlm.nih.gov/pubmed/23241131</a><br />
<br />
Previous post<br />
<a href="http://angelabiggs.blogspot.com/2016/08/5-types-of-dopamine-receptors-and-how.html">http://angelabiggs.blogspot.com/2016/08/5-types-of-dopamine-receptors-and-how.html</a><br />
<br />
<br />
interesting flu paper dealing with medications<br />
<a href="https://helda.helsinki.fi/bitstream/handle/10138/44824/denisova_dissertation.pdf">https://helda.helsinki.fi/bitstream/handle/10138/44824/denisova_dissertation.pdf</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-39265772859122135382019-04-29T16:38:00.000-07:002019-06-24T05:33:10.484-07:00IgG2 27HC or inflammasome triggering phagocytosis: How does IgG2 work? Updated with exosomes and HC patterns<div dir="ltr" style="text-align: left;" trbidi="on">
Hypotheses:<br />
27HC binds cytosolic viruses and holds them outside of the cell membrane while inflammasomes create GSDM windows in the membrane for the antibodies to bind large cytosol infections.<br />
<br />
Or HC could mark the exosomes based on what it's carrying. Cancer vs cytosol virus or mito/nuclear virus so the cd169 cells who pick up the exosomes know what they have.<br />
<br />
IgG2 and phagocytosis by neutrophils and monocytes<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457935/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457935/</a><br />
<a href="https://iai.asm.org/content/iai/63/3/1070.full.pdf">https://iai.asm.org/content/iai/63/3/1070.full.pdf</a><br />
<br />
influenza and phagocytosis<br />
<a href="http://www.jimmunol.org/content/178/4/2448">http://www.jimmunol.org/content/178/4/2448</a><br />
<br />
25HC and inflammatory reaction to influenza<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/24994901">https://www.ncbi.nlm.nih.gov/pubmed/24994901</a><br />
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Exosomes and HC<br />
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Exosomes and dendritic cells<br />
<a href="https://www.nature.com/articles/s41598-017-16609-6">https://www.nature.com/articles/s41598-017-16609-6</a><br />
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cd169 (of scs macrophages in the lymph) mediates capture of exosomes<br />
<a href="http://www.bloodjournal.org/content/123/2/208?sso-checked=true">http://www.bloodjournal.org/content/123/2/208?sso-checked=true</a><br />
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exosomes and lymph nodes<br />
<a href="https://www.sciencedirect.com/science/article/pii/S1084952116304414">https://www.sciencedirect.com/science/article/pii/S1084952116304414</a><br />
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25-HC enveloped viruses and 27-HC non-enveloped viruses<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265783/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265783/</a><br />
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Or are these nuclear/mito viruses? Herpes, flu, HIV, and HBV are all nuclear/mito viruses that would be taken up by pDendritic<br />
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27-HC Breast cancer exosomes<br />
<a href="https://www.researchgate.net/publication/293885899_Mass_spectrometric_detection_of_27-hydroxycholesterol_in_breast_cancer_exosomes">https://www.researchgate.net/publication/293885899_Mass_spectrometric_detection_of_27-hydroxycholesterol_in_breast_cancer_exosomes</a><br />
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Cancers are started by nuclear viruses but they are are growing out of control without viral participation rather they are open book growth. (the carcionogen inhibited the virus)<br />
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scs with cd169 presents viral proteins to B cells<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/17934446">https://www.ncbi.nlm.nih.gov/pubmed/17934446</a><br />
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Does the 27HC hold the viral RNA outside of infected cells for dendritic cells?<br />
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Flu B and C infects the cytosol of cells and the 25HC secreted by macrophages would insert themselves in the membranes of cells in the region...and hold the foreign viral RNA outside of the cells?<br />
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But for type A which infects the mitochondria it would lower il-10?<br />
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How does the RNA viruses in the cytosol get seen by antibodies of the immune system if the MHC1 is for mitochondrial and nuclear infections?<br />
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the inflammasome and Actinobacillus actinomycetemcomitans<br />
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490745/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490745/</a><br />
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IgG2 and Actinobacillus actinomycetemcomitans<br />
<a href="https://iai.asm.org/content/iai/63/3/1070.full.pdf">https://iai.asm.org/content/iai/63/3/1070.full.pdf</a><br />
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when the inflammasomes are involved the cells get IgG2 phagocytosis by eosinophils?<br />
<br />
The infected cells were surrounded by eosinophils<br />
<a href="https://pdfs.semanticscholar.org/a96e/7dd46755be7d0fe30724dfe926e1859e6133.pdf">https://pdfs.semanticscholar.org/a96e/7dd46755be7d0fe30724dfe926e1859e6133.pdf</a><br />
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neutrophils and IgG2 killing of actinobacillus<br />
<a href="https://iai.asm.org/content/63/3/1070">https://iai.asm.org/content/63/3/1070</a><br />
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when the actinobacillus is not in the cytosol but outside of cells?<br />
<br />
Older hypothesis post<br />
<a href="https://angelabiggs.blogspot.com/2018/04/igg2-hypotheses-requests-role-of-25hc.html">https://angelabiggs.blogspot.com/2018/04/igg2-hypotheses-requests-role-of-25hc.html</a><br />
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newer hypotheses<br />
<a href="https://angelabiggs.blogspot.com/2019/02/hypothesis-gsdm-pyroptosis-is-parasite.html">https://angelabiggs.blogspot.com/2019/02/hypothesis-gsdm-pyroptosis-is-parasite.html</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0tag:blogger.com,1999:blog-2399123431411408462.post-34226444364542835462019-04-24T07:29:00.000-07:002019-04-24T08:19:08.304-07:00ox40l and the immune system teams involved in the 3 zones<div dir="ltr" style="text-align: left;" trbidi="on">
The ox40 ligand appears on activated cells. When the T cells finally express ox40 it must determine or verify which of the 3 zones are active.<br />
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The cytokines and cytokine receptors delineating the teams </div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiHyuqNkd1v3mYWjtewUZunEfA_YxGFDuqvsb6WZ-PlsOQl98MoK_m7A0GW1qtTPoY31qVALD8hA95q8iKvAOE9h1PX_ST5LfWnneQax_BGXAyJJk-7UiYGDGTBCKlKdmyGD1hDNPP3ws4/s1600/IMG_20190424_074033.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1600" data-original-width="1200" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiHyuqNkd1v3mYWjtewUZunEfA_YxGFDuqvsb6WZ-PlsOQl98MoK_m7A0GW1qtTPoY31qVALD8hA95q8iKvAOE9h1PX_ST5LfWnneQax_BGXAyJJk-7UiYGDGTBCKlKdmyGD1hDNPP3ws4/s640/IMG_20190424_074033.jpg" width="480" /></a></div>
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The ox40L appears as members of a team become activated. Ideally only one team is on at a time. The T cells which travel between the inflammation and the lymph, talk to the rest of the immune system, and are responsible for telling the B cells which antibody to make verifies which pathway is in progress.<br />
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So what happens in autoimmune disease when 2 of these pathways are activated at the same time on one target tissue: flu virus (cytosol) and e.coli (outside) on the pancreas triggering autoimmune diabetes.<br />
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The natural Tregs that focus the pathway reactions are not activated? unclear<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/30021159">https://www.ncbi.nlm.nih.gov/pubmed/30021159</a><br />
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Biggs Hypotheseshttp://www.blogger.com/profile/02470944018846936449noreply@blogger.com0