Autoimmunity of the Brain: two tertiary lymph regions

Autoimmune disease in the area of the brain: Autoimmune hypothesis is that two infections on one target trigger autoimmunity but one infection must be an outside infection and the other an inside infection.

Neuromyelitis Optica which has antibodies to aquaporin disrupts the blood brain barrier.

Neuromyelitis has been linked to both mycobacterias and viruses like dengue.

Eosinophils and aquaporin-4
https://www.sciencedirect.com/science/article/pii/S096758681731069X

Mycobacteria (TB) and Neuromyelitis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938476/

mycobacteria and swelling of the choroid plexus
https://journals.sagepub.com/doi/abs/10.1177/0284185116633913?journalCode=acrc

lymph structure in choroid plexus
https://insight.jci.org/articles/view/124203

dengue virus can trigger Neuromyelitis
https://www.ncbi.nlm.nih.gov/pubmed/29475624

dengue and the BBB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606788/

B cells and the blood brain barrier
https://www.jci.org/articles/view/63842

in MS two groups of B cells: BBB and choroid plexus
https://onlinelibrary.ectrims-congress.eu/ectrims/2016/32nd/146268/brigitte.wildemann.cns-transmigration.of.distinct.b-cell.subsets.through.the.html

meningitis (bacteria) and choroid plexus
https://journals.sagepub.com/doi/abs/10.1177/197140091002300507?journalCode=neub

viral infections of the brain and the blood brain barrier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367119/

 Consider the two zones of the lymph split in the brain into literally two different regions.

Where the choroid plexus deals with the outer antigens and the blood brain barrier is the inner antigens.

For mycobacteria the main outside pathway involves Eosinophils.  So the IgG4 is created to stop the eosinophils.