Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications : February 2016

Monday, February 29, 2016

Analyzing the overlap of anti-phospholipid syndrome, strep, mycobacteria, campylobacteria, mycoplasmas,and alopecia

This page is just beginning...

Anti-phospholipids appear to be generated by mycobacteria, strep, mycoplasmas, and campylobacteria.

Anti-phospholipid antibodies in autoimmune diseases: lupus, gullian barre, MS, psoriatic arthritis,
http://www.ncbi.nlm.nih.gov/pubmed/2094193
http://www.japi.org/march_2010/Article_08.pdf

Antiphospholipid antibodies can cross-react with platelet glycoproteins
http://www.ncbi.nlm.nih.gov/pubmed/8713797

The different infections have different disease and autoimmune cross-targeting families but they all have the ability to generate anti-phospholipids . It may be the one thing these infections have in common.

Strep

strep and anti-cardiolipin
http://ard.bmj.com/content/61/4/374.full

rheumatic fever and anti-phospholipid
http://www.hindawi.com/journals/jir/2014/614591/
http://rheumatology.oxfordjournals.org/content/45/7/833.short
http://www.ncbi.nlm.nih.gov/pubmed/22408372

antiphospholipid and tics
http://www.ncbi.nlm.nih.gov/pubmed/16538618

chorea and antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/1813192

alopecia and strep
http://www.ncbi.nlm.nih.gov/pubmed/20525487

strep and antiphospholipid antibodies
http://www.ncbi.nlm.nih.gov/pubmed/21985124

Behcets has anti-cardiolipin and is associated with strep
http://angelabiggs.blogspot.com/2013/04/behcets-disease.html

Behcets and mitochondria polymorphisms
https://acrabstracts.org/abstract/genetic-association-of-mitochondrial-dna-polymorphisms-with-behcets-disease-in-a-korean-population/

HLA-B5, Behcets and autoimmune disease
https://acrabstracts.org/abstract/hla-b51-and-possible-associated-autoimmune-disorders-other-than-behcets-disease-a-retrospective-cohort-study/

Behcet's and herpes simplex 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857840/

erythema nodosum and behcets
https://www.ncbi.nlm.nih.gov/pubmed/22504656

TLR9 and behcet's
https://www.ncbi.nlm.nih.gov/pubmed/23237868

TLR7 and Behcets ocular? is this with a different virus?
https://www.ncbi.nlm.nih.gov/pubmed/25650422

Mycobacteria

mycobacteria and antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/23910993

mycobacteria and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pubmed/15967589

anti-cardiolipin and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757429/

antiphospholipids and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pubmed/20446442

psoriatic arthritis and antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/2778757

The skin disorder psoriasis and chron's disease have strong associations with these too.

Note that there is an earlier post talking about the quorum of mycobacteria possibly causing the type 2 diabetes and fatty liver disease.

Note that psoriasis has been connected to MS and some forms of PANDAS.

Takayasu and mycobacteria
http://angelabiggs.blogspot.com/2013/10/takayasus-caused-by-autoimmune-cross.html

APL and Takayasu
http://journals.lww.com/md-journal/Abstract/2015/12210/Takayasu_Arteritis_With.32.aspx

is this Takayasu an unusual type of mycobacteria?

Campylobacteria/sutterella
(these are very similar bacterias and were once lumped together)

Antiphospholipids and babies with autism
http://ard.bmj.com/content/early/2012/05/14/annrheumdis-2011-201167.full.pdf

sutterella and autism
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828002/

guillain barre and campylobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88896/

guillain barre and antiphospholipids
http://rheumatology.oxfordjournals.org/content/42/2/200.full

campylobacteria and sutterella are bacterial infections that typically cross over from the intestine

Mycoplasma

mycoplasma and anti-phospholipids
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426843/
http://www.ncbi.nlm.nih.gov/pubmed/22696636

adhesion glucoprotein on mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/9695283

lupus and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/26744491

RA and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/19650889

Xa antibodies in Lupus but not the rheumatic strep induced
http://www.readcube.com/articles/10.1186%2Fs13075-015-0568-7

thrombiosis and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/21378521

adenovirus and mycoplasma then antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/24598069

These infections can cross-target with viral infections and trigger the destructive form of autoimmune disease where self tissues are attacked. I call the condition autoimmune cross-targeting.

Autoimmune Cross-targeting hypothesis: 2 simultaneous infections on one target triggers autoimmunity. One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.

guillain barre could be: campylobacteria and a flavivirus at the peripheral nerves

alopecia could be: mycobacteria at the scalp and then epstein barr

Pandas could be : strep or mycobacteria with the flu at the basal ganglia

MS could be: mycobacteria with herpes zoster on central nerves

Added November 2016

antiphospholipid syndrome has been associated with HLA-DR5 and HLA-DR12

HLA-DR 12 connects to Rubella (german measles)

Rubella antibodies and antiphospholipid
https://www.ncbi.nlm.nih.gov/pubmed/22641586
https://www.ncbi.nlm.nih.gov/pubmed/19880561

Sunday, February 28, 2016

Aspergillus' quorum is oxylipins, could this match up with Asperger's?

Do the mothers of children with Asperger's have Hashimoto's and bulb allergies (garlic onions lilies) caused by Aspergillus infections? Could their children have been exposed to more oxylipins during development?

Prostaglandins and leukotrienes (oxylipins) are involved in inflammation and asthma
which could mean that aspergillus infections might involve one type of asthma

Aspergillus' quorum is oxylipins (quorums are how the fungal infections talk to each other..secreted molecules)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475224/

Prostaglandins alter the pituitary gland (stimulate hormone release)
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.474.8592&rep=rep1&type=pdf

Could the aspergillus secreted quorum interfere with our oxylipin signals?

Higher ACTH levels in adults with Asperger's
http://www.jpsychores.com/article/S0022-3999(05)00002-4/abstract

There is a larger head circumference of children born with Asperger's
http://www.ncbi.nlm.nih.gov/pubmed/12033714

There is a higher allergic response in Asperger patients

http://www.ncbi.nlm.nih.gov/pubmed/19840888

fungal infections and colitis seemed connected....is there a particular type of colitis associated to asperger's patients and their family?

aspergillus or candida found in intestinal track at autopsy
http://www.ncbi.nlm.nih.gov/pubmed/1401213

previously connected fungus with microscopic and lymphatic colitis
http://angelabiggs.blogspot.com/2013/05/microscopic-colitis.html

aspergillus if there in the intestine would it be a deeper infection?

Further note that some parasites like t.gondii use oxylipins too
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164223/

Schizophrenia has been shown to have abnormally higher ACTH levels
http://www.ncbi.nlm.nih.gov/pubmed/15219658

Friday, February 26, 2016

Y. enterocolitica triggers Graves disease NOT through autoimmune cross-targeting rather through cross-reactivity

Autoimmune Cross-targeting hypothesis: 2 simultaneous infections on one target triggers autoimmunity. One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.

This is one of the few times where the type of infection has slightly altered the type of autoimmune disease. Apparently which virus on the inside doesn't matter but the type antibody attack on the outside of the thyroid matters. Previously Hashimoto's anti-TPO antibodies was connected to the peroxidase spewed out by fungal infections. In the case of Graves disease Yersinia creates anti-thyroid antibodies against TSH receptors. The result is 2 different types of autoimmune thyroid disease.

Graves may or may not be cross-targeting autoimmunity. Since the goiter of graves is not the destruction of the thyroid rather a swelling due to over activation of the receptors. Cross-reactivity of the antibodies are stimulating the receptors causing the thyroid to over produce. The thyroid is not attacked by the immune system.

Thyroid medication for graves can however trigger the immune system to attack resulting in Hashimoto's. http://www.ncbi.nlm.nih.gov/pubmed/2434520

Which leads me to believe that true autoimmune cross-targeting leads to the destruction of the tissue by the immune system.

Multiple viruses can infect the thyroid triggering cross-targeting autoimmunity: enteroviruses, flaviviruses, entroviruses, retroviruses and even herpes viruses. (or medication can mark the inside of the thyroid as foreign instead of the virus)

Only yersinia seems connected to Graves as the outer infection. The yersinia connection is well documented and accepted. The question now is: can other infections like e.coli or mycoplasmas create the TSH receptor antibodies?

For the Graves disease type of thyroid autoimmune disease only Yersinia infections appear to trigger the antibodies against the TSH receptor

coxsackie, graves and y.entercolitica
http://www.ncbi.nlm.nih.gov/pubmed/9561915

graves and y.enterocolitica
http://www.ncbi.nlm.nih.gov/pubmed/23630351
http://www.ncbi.nlm.nih.gov/pubmed/12193307
http://www.ncbi.nlm.nih.gov/pubmed/2083529

Graves' disease and immune thrombocytopenia (ITP)
http://www.ncbi.nlm.nih.gov/pubmed/26278293

thrombocytopenia and yersinia
http://www.ncbi.nlm.nih.gov/pubmed/3993437

haemolytic uraemolytic syndrome and yersinia
http://www.ncbi.nlm.nih.gov/pubmed/3153031
http://www.ncbi.nlm.nih.gov/pubmed/1936156

reactive arthritis and yersinia
http://www.ncbi.nlm.nih.gov/pubmed/3662638

note my earlier post considering yersinia and fish allergy
http://angelabiggs.blogspot.com/2015/04/fish-allergy-and-yersinia-infections.html

spirochetes could do this too

Thrombocytopenia and spirochetes
http://www.ncbi.nlm.nih.gov/pubmed/7044515

spirochetes and yersina share thyroid antigens
http://www.ncbi.nlm.nih.gov/pubmed/16571084
http://www.ncbi.nlm.nih.gov/pubmed/15671776

relationship between graves disease and h.pylori but not hoshimotos
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296983/

For graves disease to become a Cross-targeting autoimmune disease a virus or medication must mark the inside as foreign and the immune system must catch the antibody binding the receptor quickly before it disappears.

Graves and hepatitis C
http://www.ncbi.nlm.nih.gov/pubmed/25603854
http://www.ncbi.nlm.nih.gov/pubmed/10426583

http://www.ncbi.nlm.nih.gov/pubmed/12729321
http://www.ncbi.nlm.nih.gov/pubmed/21928702
http://www.ncbi.nlm.nih.gov/pubmed/16025878

viruses and autoimmune thyroid disease
http://www.ncbi.nlm.nih.gov/pubmed/19138419

Coxsackie is a culprit for goiter
http://www.ncbi.nlm.nih.gov/pubmed/2853353

Note that typically the list of viruses trigger autoimmunity is smaller but the thyroid has a variety of receptors thus a larger group of viruses.

Cross-reactivity is when an antibody binds not just the antigen(sequence) of the infection but an antigen of self because the protein is either the same or similar enough. Our own body has accidentally become labeled with infection flags.

Graves is when the receptor is not just marked by an antibody but activated by it. The reason autoimmune attack on the thyroid is not triggered as often may do with the "activation" and quick cycling of the receptor away from the membrane surface. The immune system has less chance to see it. Hashimoto's can result but the "window" is smaller.

Friday, February 19, 2016

Tyrosol as a quorum of Trichophyton? connections to discord lupus and vitiligo? ALS and a toxin secreting Trichophyton?

other possible fungal infections: Malassezia or saccharomyces or Cryptococcus neoformans

Malassezia was connected to seborrheic dermatitis
http://www.ncbi.nlm.nih.gov/pubmed/26786542
http://www.ncbi.nlm.nih.gov/pubmed/11092380

Saccharomyces infections are typically found in the gut or lungs (baker's asthma)

Aspergillus typically infects the lungs and guts (previously pondered a bulb plant allergy with this: onions, lilies, garlic) Aspergillus is the most common fungus attacking the brain.

Note that aspergillus has symbiotic relationships with bacteria
http://www.ncbi.nlm.nih.gov/pubmed/26856310

Candida also has a symbiotic relationships with bacteria

staph and candida together as growing partners
http://www.bioone.org/doi/abs/10.1893/0005-3155-84.1.30
http://www.ncbi.nlm.nih.gov/pubmed/26262843

Lupus and staph linked
http://www.huffingtonpost.com/2012/08/08/lupus-risk-staph-bacteria_n_1758258.html

Staph makes a pigment with egg and milk
The allergies associated with eczema and lupus could be because of staph infections developing pigment when it sees egg or milk.

Does staph grow with Trichonphyton too? Egg and milk allergies seem to exist with vitiligo.

Note that a previous hypothesis on this blog suggests that gluten sensitivity comes from infections crossing barriers, intestine, lung or the blood brain barrier. Only when the fungal infection has broken through one does gluten sensitivity occur. (when T.gondi breaks through the intestine gluten sensitivity occurs in a similar manner)

tangent thought

Sour cream inhibits tyrosinase
Does sour cream confuse trichophyton? Could eating sour cream help limit the growth of the fungus or would it make the vitiligo worse?
Can applying sour cream to freckles can make them disappear?

This next part might become it's own blog post soon.

I have looked at trichophyton before as a connection to ALS. It could be one of the other fungal infections though.

Is ALS an autoimmune cross-targeting disease of trichophyton or similar fungus and a virus? NO mulitiple sclerosis is an autoimmune attack on the nerves. ALS is the "breakdown of the nerves"

Can infections of the feet explain the sport association of ALS? Lou Gehrig's disease
Trichophyton is the most common skin fungus and causes athletes foot.
http://www.ncbi.nlm.nih.gov/pubmed/18578874

Trichophyton has a wood rot variety: T. rubrum

This could be found in rotting beaver dams....which might explain the ALS clusters around lakes in north America.
http://link.springer.com/article/10.3839%2Fjksabc.2010.026#page-1

Lupus can overlap amyotrophic lateral sclerosis (ALS)
http://www.ncbi.nlm.nih.gov/pubmed/11908583
http://www.ncbi.nlm.nih.gov/pubmed/15200286
http://www.shmabstracts.com/abstract/amyotrophic-lateral-sclerosisals-in-a-patient-with-systemic-lupus-erythematosus-sle/

so how would a skin fungus cause nerves to die?

amyloid beta is in skin of ALS which means the mitochondrias are destroyed
http://www.ncbi.nlm.nih.gov/pubmed/11041332

Some of these fungal infections that live on us create toxins: aflatoxin made my aspergillus damages the mitochondria

Aflatoxin damages the mitochondria
http://researchspace.ukzn.ac.za/xmlui/handle/10413/7851

Aflatoxin like compounds are made by some dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum

Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf

High rates of trichophyton concentricum on Solomon children (close to guam and makes you wonder if both areas share this infection)
https://www.researchgate.net/publication/281516255_Trichophyton_concentricum_in_skin_lesions_in_children_from_the_Salomon_Islands

ALS and lakes in new england
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922844/

Has T.concetricum appeared in these lakes?

So the questions we need to solve: which fungus matches up with which disorders?

How much tyrosol does pityriasis versicolor make? another pigment loss skin disorder

In addition to farnesol, the other known fungal QSMs are all alcohols derived from aromatic amino acids tyrosine (tyrosol), phenylalanine (phenylethanol) and tryptophan (tryptophol).
https://mmy.oxfordjournals.org/content/50/4/337.full#ref-13

Monday, February 15, 2016

pernicious anemia with Fungal infections vs. hemolytic anemia with the mycoplasmas of rheumatoid ?

Pernicious anemia from a lack of absorption from B12

Fungal infections creating B12 deficiency could cause pernicious anemia

Pernicious anemia and alopecia
http://www.ncbi.nlm.nih.gov/pubmed/18614380

Vitiligo and pernicious anemia
http://www.nejm.org/doi/full/10.1056/NEJMicm990602

alopecia areata and vitiligo
http://www.ncbi.nlm.nih.gov/pubmed/8838924

Herpes and vitiligo (cross-targeting?)
http://www.ncbi.nlm.nih.gov/pubmed/11277493

Spondyloarthritis and vitiligo (arthritis of the spine)
http://www.ncbi.nlm.nih.gov/pubmed/11246668

fungal exposure in homes of scarcoidosis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036600/

vitiligo discord lupus and trichophyton
http://www.ncbi.nlm.nih.gov/pubmed/11036404

The Candida infection and pernicious anemia with B12 deficiency is documented.

it is also possible that the cytokine TGF produced by the immune system while fighting the fungal infection also adds to the anemia

Hemolytic anemia: can be caused by multiple infections included mycoplasmas, e.coli, gingivitis

Hemolytic anemia has already been linked to mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/988873
http://www.ncbi.nlm.nih.gov/pubmed/577971

mycoplasmas and rheumatoid
http://www.ncbi.nlm.nih.gov/pubmed/26058928

mycoplasmas in bloodstream of RA
http://www.ncbi.nlm.nih.gov/pubmed/19650889

alopecia and mycoplasmas
RA medication has been shown to reverse alopecia

enolase surface protein binds mycoplasma and other bacterias to red blood cells
http://www.ncbi.nlm.nih.gov/pubmed/22047714

citrullinated peptide antibodies and Rheumatoid arthritis
http://www.ncbi.nlm.nih.gov/pubmed/21199462

cross-reactivity between RA antibodies and bacteria citrullinated enolase
http://www.ncbi.nlm.nih.gov/pubmed/18821669

Wednesday, February 10, 2016

Is dyslexia caused by a herpes viral infection during pregnancy? Is there an overlap with vertigo, migraine, and tinnitus?

If a virus infects a baby's brain does a learning disability develops?

Herpes viruses like zoster, cmv, and HHV6 infect the temporal lobe. Can this trigger dyslexia or autism. Does the virus alone cause dyslexia or deafness?

Many babies exposed to CMV have been shown to develop dyslexia
http://www.congenitalcmv.org/preschool.pdf

auditory neuropathy in infant after cmv infection
http://www.ncbi.nlm.nih.gov/pubmed/22789691

HSV1 has been linked to spatial learning too
http://ns.umich.edu/new/releases/21854-herpes-viruses-associated-with-cognitive-impairment
http://www.ncbi.nlm.nih.gov/pubmed/24253286

images of viruses infecting the brain
http://www.neurology.org/content/70/1/84.full.pdf

migraine and vertigo??
http://vestibular.org/migraine-associated-vertigo-mav

CMV and vertigo??
http://forums.phoenixrising.me/index.php?threads/vertigo-viral-or-bacterial-cause.24867/

gaze tinnitus...issues of the 8th nerve or vestibulocochlear nerve
https://www.ncbi.nlm.nih.gov/pubmed/11568674

cmv and vestibulocochlear nerve (auditory vestibular nerve), known as the eighth cranial nerve
has 2 areas: vestibular and cochlear meaning balance and hearing

CMV can cause hearing loss
http://www.ncbi.nlm.nih.gov/pubmed/17959414

Meniere's disease and vertigo are linked to a virus
http://www.ncbi.nlm.nih.gov/pubmed/19142031
http://www.ncbi.nlm.nih.gov/pubmed/18235200

naming deficit after herpes simplex 1 infection
http://www.ncbi.nlm.nih.gov/pubmed/1565801
http://www.ncbi.nlm.nih.gov/pubmed/6206910
http://www.ncbi.nlm.nih.gov/pubmed/3225585

meniere's in children: vertigo and tinnitus
http://www.ncbi.nlm.nih.gov/pubmed/16623983

strokes and acquired dyslexia alzheimer's. Is herpes zoster involved?
http://www.ncbi.nlm.nih.gov/pubmed/22034787

Herpes zoster and stroke risk have been connected
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902756/
http://cid.oxfordjournals.org/content/early/2014/03/25/cid.ciu098.abstract
http://www.neurology.org/content/82/3/206
http://www.ncbi.nlm.nih.gov/pubmed/25712420

migraines and dyslexia seem to have an overlap too. After a migraine dyslexia can follow.
http://www.ncbi.nlm.nih.gov/pubmed/25496701

migraine followed by motion dyslexia
http://www.ncbi.nlm.nih.gov/pubmed/22529196
http://www.ncbi.nlm.nih.gov/pubmed/16162255

history of migraine and the development of alzheimer's
http://ispub.com/IJH/8/2/11263

Migraine and amyloid
http://www.ncbi.nlm.nih.gov/pubmed/26611682

Note that amyloid appears after mitochondrial damage:

popcorn lung's diacetyl ...causes amyloid
http://www.ncbi.nlm.nih.gov/pubmed/22731744

herpes infections also cause amyloid
http://www.ncbi.nlm.nih.gov/pubmed/17980964

since herpes viruses go dormant in the mitochondria of nerves (we know shingles does not occur all the time) are children with dyslexia at risk for the virus awakening? do they have dormant viral infections?

early childhood development disorders and the overlap of alzheimer's is currently being debated
http://www.alzforum.org/news/conference-coverage/does-brain-development-childhood-set-stage-dementia

Tuesday, February 9, 2016

Mycobacterias and canker sores (aphthous)

Canker sores or aphthous ulcers are gluten and casein sensitive.

Canker sores have strong associations with crohn's, psoriasis, and psoriatic arthritis which have previously been connected to mycobacterial infections. All of which have strong gluten and casein sensitivities.

It is suggestive that a canker sore is an immune reaction to an oral mycobacterial infection.

canker sores (aphthous ulcers or aphthous stomatitis) and mycobacteria
https://www.karger.com/Article/Pdf/246355

canker sores and crohn's
http://www.ncbi.nlm.nih.gov/pubmed/24217985
http://www.ncbi.nlm.nih.gov/pubmed/26240765

mycobacteria's and crohn's
http://www.ncbi.nlm.nih.gov/pubmed/17317344

psoriatic arthritis and canker sores
http://www.drugs.com/answers/i-have-psoriatic-arthritis-am-suffering-with-338990.html

psoriatic arthritis/septic and mycobacteria
http://www.hindawi.com/journals/jir/2012/747204/
http://rheumatology.oxfordjournals.org/content/38/6/547.full.pdf
https://www.researchgate.net/publication/221891761_Cutaneous_Mycobacterium_marinum_infection_mimicking_felon_in_a_patient_with_psoriatic_arthritis_treated_with_infliximab

psoriasis and canker sores
https://www.glutenfreesociety.org/canker-sores-a-sign-of-gluten-sensitivity/

cow's milk and aphthous ulcers
http://www.pubfacts.com/detail/22924810/The-role-of-specific-cows-milk-proteins-in-the-etiology-of-recurrent-aphthous-ulcers
antibodies were generated against the caseins

gluten sensitive too
http://www.ncbi.nlm.nih.gov/pubmed/7261838
http://www.ncbi.nlm.nih.gov/pubmed/1247715

mycobacteria, crohn's and aphthous
http://www.ncbi.nlm.nih.gov/pubmed/26849125

lip swelling and crohn's (which mycobacteria is this?)
http://www.ncbi.nlm.nih.gov/pubmed/10027998
http://www.ncbi.nlm.nih.gov/pubmed/12066767

Pre-diabetes type 2 and mouth ulcers
http://www.ncbi.nlm.nih.gov/pubmed/23790473

beginning of mycobacteria quorum paper
http://angelabiggs.blogspot.com/2015/12/mycobacterias-possible-connection-to.html
http://angelabiggs.blogspot.com/2015/12/the-conundrum-of-high-cholesterol-type2.html
How the quorum of mycobacteria could be causing the fatty liver disease and type 2 diabetes.

alum works to treat canker sores...and is a known antibacterial agent

Alum
https://en.wikipedia.org/wiki/Alum
A type of aluminum compound used in roman times to purify drinking water and later in Florance to dye cloth.

Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications