Autoimmune Hypothesis: a dimorphic infection produces antibodies until a secondary viral infection produces antibodies that cross-target thus triggering the autoimmune disease.
collagenous colitis and lympocytoic are different forms of IBS microscopic colitis
Lymphocytic colitis tends to be the non bloody diarrhea form.
Microscopic divided into Collagenous and Lymphocytic
http://www.ncbi.nlm.nih.gov/pubmed/2912870
Collagenous microscopic colitis is associated with anti-saccharomyces antibodies
http://www.ncbi.nlm.nih.gov/pubmed/?term=collagenous+colitis+saccharomyces
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2005.04027.x/abstract
IBS and candida
http://www.ncbi.nlm.nih.gov/pubmed/20885347
Lymphocytic colitis is associated with Candida
http://www.ncbi.nlm.nih.gov/pubmed/23314667
Lymphocytes actually bind the candida
http://www.ncbi.nlm.nih.gov/pubmed/11796578
http://www.ncbi.nlm.nih.gov/pubmed/8660804
Microscopic colitis affects women more often then men
http://www.ncbi.nlm.nih.gov/pubmed/20878755
Fungal infections change morphology with estrogen. It is possible that these fungal infections generate the antibodies as they peek-a-boo between mold and yeast forms. Since soy is a natural estrogen a patient may be sensitive to soy. (E.coli which I have connected to Celiac disease is not a fungal infection and is probably not estrogen or soy sensitive.)
Another difference between celiac disease and IBS maybe the gas produced after sugar intake. Fungal infections feed on sugar and produce gas.
( E.coli would not do this thus true celiac disease does not have the bloating after sugar intake rather e.coli turns the sugar into a slime which is seen as mucus in the diarrhea however....c.diff or c.sordelli does make gas)
Remember this is a hypothesis blog. This has not been proven but I am suggesting how things could be occurring.
If the infections are playing peek-a-boo...and tons of antibodies are being generated what then pushes the immune system into attack, into what we truly call an autoimmune disease I believe requires an virus.
The Viral cross-targeting the intestine seems likely to be the rotavirus or norovirus or cytomegalovirus
http://www.ncbi.nlm.nih.gov/pubmed/17249458
Is IBS merely fungal infections? For the damage to the intestine to occur does the virus have to be there? Is it really an autoimmune disease or just inflammation looking for the virus?
I hope my thoughts help someone out there figure out their disease.
Angela Biggs
UPDATED Feb 25 2016: Gluten sensitivity means you have an infection that crosses barriers : intestinal or blood brain barrier
collagenous colitis and lympocytoic are different forms of IBS microscopic colitis
Lymphocytic colitis tends to be the non bloody diarrhea form.
Microscopic divided into Collagenous and Lymphocytic
http://www.ncbi.nlm.nih.gov/pubmed/2912870
Collagenous microscopic colitis is associated with anti-saccharomyces antibodies
http://www.ncbi.nlm.nih.gov/pubmed/?term=collagenous+colitis+saccharomyces
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2005.04027.x/abstract
IBS and candida
http://www.ncbi.nlm.nih.gov/pubmed/20885347
Lymphocytic colitis is associated with Candida
http://www.ncbi.nlm.nih.gov/pubmed/23314667
Lymphocytes actually bind the candida
http://www.ncbi.nlm.nih.gov/pubmed/11796578
http://www.ncbi.nlm.nih.gov/pubmed/8660804
Microscopic colitis affects women more often then men
http://www.ncbi.nlm.nih.gov/pubmed/20878755
Fungal infections change morphology with estrogen. It is possible that these fungal infections generate the antibodies as they peek-a-boo between mold and yeast forms. Since soy is a natural estrogen a patient may be sensitive to soy. (E.coli which I have connected to Celiac disease is not a fungal infection and is probably not estrogen or soy sensitive.)
Another difference between celiac disease and IBS maybe the gas produced after sugar intake. Fungal infections feed on sugar and produce gas.
( E.coli would not do this thus true celiac disease does not have the bloating after sugar intake rather e.coli turns the sugar into a slime which is seen as mucus in the diarrhea however....c.diff or c.sordelli does make gas)
Remember this is a hypothesis blog. This has not been proven but I am suggesting how things could be occurring.
If the infections are playing peek-a-boo...and tons of antibodies are being generated what then pushes the immune system into attack, into what we truly call an autoimmune disease I believe requires an virus.
The Viral cross-targeting the intestine seems likely to be the rotavirus or norovirus or cytomegalovirus
http://www.ncbi.nlm.nih.gov/pubmed/17249458
Is IBS merely fungal infections? For the damage to the intestine to occur does the virus have to be there? Is it really an autoimmune disease or just inflammation looking for the virus?
I hope my thoughts help someone out there figure out their disease.
Angela Biggs
UPDATED Feb 25 2016: Gluten sensitivity means you have an infection that crosses barriers : intestinal or blood brain barrier
Thanks for this interesting article. I myself have Lymphocytic colitis and Meniere's disease. I believe these two conditions are linked with each other and have something to do with either viral or fungal infections (or both). More insights on this would be welcome!
ReplyDeleteHenri
Hi,
DeleteHere is the old blog post of Meniere's disease. I will look at it again to see if things are clearer.
http://angelabiggs.blogspot.com/2013/04/meniere.html
new Meniere's post entered for you today. unfortunately it is still unclear which virus is involved.
DeleteThank you, I will look into it.
DeleteNO longer unclear which virus. There are enough papers to suggest that a herpes virus infects the nerve triggering the cross-targeting. I put all the references on the newer post. http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-and-menieres.html
ReplyDeleteThanks, I'd better get some tests done for the VZV virus then!
ReplyDeleteI mean HSV
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