T gamma delta as tumor cell killers

il-15 convert Tgamma delta cells into nk-like cells which specialize in fighting cancer.

Hypothesis:

The delta one version focuses on early cancer wearing nkp44 and nkp30 while the delta two T cells with DNAM-1 focus on late cancers specifically the metastasized cancers wearing cd155.

Tgamma delta and cancer, they act with NK and alone
https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=20519625

delta2  T gammadelta cells degranulate
https://www.ncbi.nlm.nih.gov/pubmed/24228383

il-15 to Tgamma delta is nk like
https://jhoonline.biomedcentral.com/articles/10.1186/s13045-016-0329-3

il-15 as a cancer treatment.
https://ccr.cancer.gov/news/inthejournals/itj_conlon

nkp44 binds the ligands on tumors: mll5 or pdgf-dd (cell cycle ligand and growth factor ligand)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811168/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081859/

cd155 and metastasized cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524493/

DNAM-1 and cd155
https://www.ncbi.nlm.nih.gov/pubmed/20008292

note that in pregnancy NK cells do not have nkp44 or DNAM-1 on them

Not all the Tgammadeltas act like NK

il-12 creates TH1 like t gamma delta
https://jvi.asm.org/content/76/13/6487

il-9 secretion of T gamma delta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098669/


il-2 on Tgammadelta is th17 like
https://www.ncbi.nlm.nih.gov/pubmed/28835458

Matching up cytokines with antibodies

B cells require il-21 to become plasma cells etc
https://www.ncbi.nlm.nih.gov/pubmed/17947662

il-10 and IgG3
https://www.ncbi.nlm.nih.gov/pubmed/8671667

IFN gamma IgG2
https://www.ncbi.nlm.nih.gov/pubmed/8131203

il-4 and IgG1, IgE
https://www.ncbi.nlm.nih.gov/pubmed/2789429

il-4 and il-5 and IgA
https://www.ncbi.nlm.nih.gov/pubmed/3262648