Monday, July 22, 2013

Bipolar disorder is not autoimmune but it could be caused by Graves which is autoimmune

Most of this Blog focuses on an autoimmune hypothesis where 2 infections cross-target on a cell type then autoimmunity develops.

When I looked at bipolar I realized it was not itself autoimmune but from autoimmune thyroid disease not under control.  Thyroid issues need to be identified quickly and continuously monitored so health does not become worse.

Bipolar disease patients have increased monoamine neurons in their brains. Thyroid hormones are involved in the development and regeneration of brain cells. http://www.ncbi.nlm.nih.gov/pubmed/?term=monoamine+bipolar+neurons+Zubieta

Graves disease which is a hyper thyroid disorder where excess thyroid hormone is produced. Bipolar patients have a history of Graves disease. (references coming soon page under construction still)
http://www.ncbi.nlm.nih.gov/pubmed/22842504
http://www.ncbi.nlm.nih.gov/pubmed/22520715
http://www.ncbi.nlm.nih.gov/pubmed/15763125
http://www.ncbi.nlm.nih.gov/pubmed/16271661

Graves disease I have as an autoimmune disorder connected with the mycoplasma infection group: RA, LUPUS, chronic asthma, and some type 1 diabetes.
http://www.ncbi.nlm.nih.gov/pubmed/?term=mycoplasma+graves 
http://www.ncbi.nlm.nih.gov/pubmed/11128659
http://www.ncbi.nlm.nih.gov/pubmed/8943749

Unlike schizophrenia where infections have a direct involvement triggering the autoimmunity to the brain, bipolar I believe is a result of the hyper thyroid.....autoimmunity at the thyroid not at the brain. The thyroid telling the brain cells to grow in excess.

This fits with my theory of Alzheimer's and growth.  Thyroid stimulating hormone receptor is over expressed in the brain of patients with Alzheimer's and Down syndrome, those with mitochondrial defects where neuron growth would be stifled and the brain would attempt to over ride the system and increase growth.  (I have suggested that the APP protein is a growth-on serine protease encouraging neuron growth)

Overlaps and misdiagnosis of the elderly between Bipolar and Alzheimer's disease has occurred because of an overlap in memory loss and mood swings.  Perhaps by comparing these 2 different diseases we may figure out how they work faster...giving clues to the normal functioning system and revealing how the thyroid controls brain cell growth.

Another interesting tangent has to do with Hypothyroid, Hashimoto's disease. What if OCD was linked to the hypothyroid condition...I am looking for references to confirm.  Genetically altered mice with a point mutation in the receptor for thyroid stimulating hormone had less of the neurons and developed repetitive movement disorders.  http://www.ncbi.nlm.nih.gov/pubmed/11530227  Autoimmune hypothyroid I have weakly linked to the fungal infections like aspergillus and candida. 

Strep has been associated with OCD which made me wonder if it effected the thyroid: yes it does. http://www.ncbi.nlm.nih.gov/pubmed/23435638 Streptococcus anginosus infections suppressed the TSH of the thyroid in both of these patients.

The other interesting overlap I have stumbled upon here: stuttering & low TSH.  Autistic kids given the Alzheimer's drug Memantine started stuttering....which makes me think that Memantine is not just a NMDA receptor antagonist but a TSH receptor antagonist.....? 

I hope these thoughts spark research, hope, and stop the worsening of biopolar or OCD in patients.
Angela Biggs