Sjogren's is it caused by cross-targeting autoimmunity/

Hypothesis: An infection, like candida, generates antibodies in the early stages but the autoimmune disease does not develop until a virus cross-targets causing the immune system to malfunction.

For Sjogren's the cross-targeting focus might be T lymphocytes. The infection generating antibodies against the lymphocytes and then the virus infecting the T lymphocyte.

 The resulting inflammation would then be occurring where the candida infections are and the T cells are investigating...the moist areas of the body.  This is just a hypothesis.

Infection: Candida associated with Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/12973284
http://www.ncbi.nlm.nih.gov/pubmed/21737184 
http://www.medicinaoral.com/pubmed/medoralv15_i2_p310.pdf
http://iadr.confex.com/iadr/2005Balt/techprogram/abstract_63189.htm

overlap of Sjogren's with non-Hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/22198497
http://www.ncbi.nlm.nih.gov/pubmed/22047044

non-Hodgkin's lymphoma with candida
http://www.ncbi.nlm.nih.gov/pubmed/20098335
http://www.ncbi.nlm.nih.gov/pubmed/14650581 
 
anti-nuclear antibodies cross react with lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/335492
 
So the question is: Does Candida generate anti-nuclear antibodies?  Searching for this now.

Here is a patient with anti-lymphocyte antibodies and a Candida infection
http://www.ncbi.nlm.nih.gov/pubmed/7007634

Lymphocytes grow out of control with Anti-candida antibodies
http://www.ncbi.nlm.nih.gov/pubmed/3531938

So if Candida is the infection that causes the the build up of antibodies in the first stage what virus causes the cross-targeting?

Hepatitis C can infect Lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/22278227

Virus: hepatits C and Sjogren
http://iadr.confex.com/iadr/2005Balt/techprogram/abstract_63189.htm
http://www.ncbi.nlm.nih.gov/pubmed/10357112
http://www.ncbi.nlm.nih.gov/pubmed/15758837

CMV and Sjogren?
http://www.ncbi.nlm.nih.gov/pubmed/24312567 
http://www.ncbi.nlm.nih.gov/pubmed/18286353

no CMV but epstein-barr?
http://www.ncbi.nlm.nih.gov/pubmed/22332375
http://www.ncbi.nlm.nih.gov/pubmed/12847443


A further interesting thought:

Hypothyroid and Sjogren
http://www.ncbi.nlm.nih.gov/pubmed/17558463
I suspect that fungal infections like aspergillus and candida are linked to hypothyroid (Hashimoto's) with Epstein-barr virus as the cross-targeting trigger.  See newer post with Asperger's overlap.