Type 2 diabetes : the pancreas makes insulin but the body's cells do not respond to the insulin.

Normally insulin from the pancreas stimulates the body's cells to produce NO which then activates cGMP which stimulates the glucose transporter to import glucose.

Mycobacterias use cGMP for quorum sensing, communicating the growth of the biofilm mycobacteria colony.

If the body is infected with mycobacterias could the cGMP released by them disrupt the host's system causing the cells not to respond to insulin? cGMP does control the glucose transporter. Normally insulin raises NO which then triggers cGMP to turn on and import glucose at the transporter.

High cholesterol tends to exist with Type 2 diabetes too. Could cGMP be upsetting the liver which makes the cholesterol? Does high plasma cGMP cause nonalcoholic fatty liver disease? not the other way around? Fatty liver disease has been found statistically high with tuberculosis patients.

Resveratrol has been shown to decrease fat deposits in the liver. Resveratrol has been shown to activate cGMP in cells. Has intracellular cGMP been suppressed because of the high plasma cGMP from mycobacterias?

Testosterone is made from cholesterol in the body. Why would testosterone be low when cholesterol is high?

Testosterone is made in the testicles. The level of cGMP is critical for the proper function of males. Cholesterol is made into testosterone then the testosterone triggers cGMP. cGMP is raised for reaction but then must go down. If cGMP is abnormally high it would make sense that the body would suppress testosterone production to keep internal cGMP lower?

Note that psoriasis has been associated with mycobacterias. Psoriasis alone has been associated with a risk of fatty liver disease.

Chron's has also been associated with fatty liver disease

http://www.ncbi.nlm.nih.gov/pubmed/16514570

Earlier post about mycobacterias:

http://angelabiggs.blogspot.com/2013/06/mycobacteria-diseases-psoriasis-chrons.html

References:

mycobacteria's use and require cholesterol

http://nopr.niscair.res.in/bitstream/123456789/4363/1/IJEB%2047(6)%20407-411.pdf

2013 Aug;9(8):479-93. doi: 10.1038/nrendo.2013.122. Epub 2013 Jun 25.

Testosterone and insulin resistance in the metabolic syndrome and T2DM in men.

Rao PM1, Kelly DM, Jones TH.

http://www.ncbi.nlm.nih.gov/pubmed/23797822?dopt=Abstract&holding=f1000,f1000m,isrctn

Mycobacteria in host macrophage uses cholesterol
http://www.sciencedirect.com/science/article/pii/S1074552112000099

Quorum sensing and biofilm formation in mycobacteria: role of c-di-GMP and methods to study this second messenger.

Sharma IM1, Petchiappan A, Chatterji D.

Testosterone protects against type 2 diabetes in men

http://www.ncbi.nlm.nih.gov/pubmed/20126841

Testosterone and its precursors and metabolites enhance guanylate cyclase activity (progesterone/5a-dihydrotestosterone/pregnenolone/cyclic GMP) DAVID L. VESELY
http://www.pnas.org/content/76/7/3491.full.pdf

Insulin stimulates cGMP pathway in smooth muscle

http://www.ncbi.nlm.nih.gov/pubmed/14615391

non alcoholic fatty liver disease with type 2 diabetes...70% of those with type 2

http://www.ncbi.nlm.nih.gov/pubmed/19262374
http://care.diabetesjournals.org/content/30/6/e56.full

Fatty liver disease with TB

http://archinte.jamanetwork.com/article.aspx?articleid=550748

mycobacteria and metabolic syndrome

http://www.ncbi.nlm.nih.gov/pubmed/18448263

TB and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887603/