The bacteria Stenotrophomonas possible connection to fibromyalgia and pituitary tumors.

Title  

Stenotrophomonas possible connection to fibromyalgia and pituitary tumors.

Abstract

Stenotrophomona infections could cause disease when the butyrolactones they produce convert to GHB in the human body.  This hypothesis suggests a common connection to strenotrophomona which explains the known overlap with the fibromyalgia, osteoarthritis, ovarian cysts, dyspnea,  osteophytes , and pituitary tumors.

Introduction

Xanthomona is the "black rot "bacteria that infects plants favoring nightshade plants. They use butyrolactones as signaling molecules between them.  One form of Xanthomonas has been found to infect the respiratory tract of people and is considered a new bacterial genus: Xanthomonas maltophilia was renamed Stenotrophomonas maltophilia.  Xanthomonas has been known to infect surgical bone equipment as well.  People with osteoarthritis have noticed sensitivities to nightshades which could reflect the origins of the bacteria. Further Stenotrophomonas maltophilia is unable to ferment lactose possibly causing sensitivities to lactose in people.   This hypothesis makes the assumption that stenotrophomonas infections of the body signal like the xanthomonas of plants and make butyrolactones which interfere with normal GABA signals.

Hypothesis

Stenotrophomonas produce butyrolactones which  converts  to GHB in the human body. The GHB could trigger the immune system to develop antibodies to GABA.  If this occurs the immune system could confuse an immune attack against the bacteria stenotrophomonas with nerve endings. An immune attack at nerve endings could be the cause of fibromyalgia.  The GHB could if in high levels in the blood stream reach the pituitary and over stimulate it.  When the pituitary over produces hormones they cause ovarian cysts, dyspnea, and osteoarthritis.  High GHB could be the cause pituitary tumors.  This paper will analyze the areas of overlap and try to prove that stentrophomonas are there.

Evaluation of Hypothesis

Fibromyalgia, osteoarthritis, ovarian cysts, dyspnea, osteophytes, and pituitary tumors overlap but the reason why is unknown.  It is my contention that stenotrophomonas links them together.

Stenotrophomonas  is typically, historically been a respiratory or septic infection of immune compromised or cystic fibrosis patients.  Recently surgeries have resulted in cases of Strenotrophomona infection.  What happens in a person with a healthy, non suppressed immune system when they have Strenotrophomona?

If stenotrophomonas are in the body producing butyrolactones the body would converts these butyrolactones  into GHB, 4-hydroxybutanoic acid.

The GHB made by the bacteria over stimulates the pituitary causing an increase in growth hormone. (similar to acromegaly) Excess growth hormone alters bone metabolism which could be causing the osteoarthritis and bone spurs we see.

Patients with bone marrow or bone spur surgery have increasingly developed metastic cellulitis from stenotrophomona following surgery.   Follow up should be done on any surgery that resulted in an infection because it is likely that if the bacteria persists in the patient osteophytes and osteoarthritis could occur.

Osteophytes, bone spurs,  have strong associations with dyspnea or troubled breathing. ( Osteoarthritis has been associated with bone spurs and is very different from the bone spurs of psoriatic arthritis. )   Osteoarthritis has also been found to have high rates of dyspnea in the elderly.   Could dyspnea be the result of high GHB?  yes.

GHB acts as a central nervous system depressor.  

In fact GHB is also known as the narcotic date rape drug and  a woman who started giving this party drug version to herself on a daily basis for 2 years developed Crushing disease.  Crushing disease is a pituitary tumor that releases too much ACTH. 

GHB has a direct effect on the pituitary as a strong stimulator because it is so similar to GABA and binds the GABA receptors which are not just present at nerve endings  but are present on the pituitary gland.

Normally GABA stimulates the pituitary and is thought to alter hormone release but obviously long term over stimulation of the receptors causes Crushing disease tumors. 

Fibromyalgia has been associated with pituitary dysfunction and abnormal ACTH.   Fibromyalgia has also been associated with Osteoarthritis and lower back pain.  Osteoarthritis of the spine’s discs is believed to be the cause of lower back pain.  

Fibromyalgia has been linked to dyspnea and breathing issues.  Interestingly dyspnea has correlations with osteoarthritis and osteophytes which is the bone spurs.  The pituitary has also been associated with dyspnea.   Is dyspnea caused by GHB from stenotrophomonas?  Is fibromyalgia caused by GHB antibodies?

If the bacteria is secreting compounds that become GHB are there antibodies to GHB in fibromyalgia patients? GHB and GABA are such tiny molecules can antibodies be generated against them? How similar are they? How much cross reactivity exists? Does albumin bind to them and help to generate the antibodies by making it a larger compound? 

Fibromyalgia patients have been found with polycystic syndrome.  Pituitary tumors can produce high levels of FSH which cause ovary dysfunction specifically polycystic syndrome.

Erectile dysfunction can be caused in men with pituitary adenomas. 

The Date Rape drug is actually improperly used sleep aid medications which means long term prescribed use can also cause pituitary tumors, dyspnea,  osteoarthritis and the reproductive issues.  Xyrem is GHB.  Ambien is GABA.  No fibromyalgia would be triggered by medications because the immune system is not involved as it is in stenotrophomona infections .

This paper is still being written.

note that this bacteria does not like Chili peppers
http://www.ncbi.nlm.nih.gov/pubmed/27493606

Link to older post of references
http://angelabiggs.blogspot.com/2015/02/fibromyalgia-is-it-autoimmune-no-right.html

Chronic fatigue, fibromyalgia, and the pituitary
http://www.ncbi.nlm.nih.gov/pubmed/25832514
http://www.ncbi.nlm.nih.gov/pubmed/24959566
http://www.ncbi.nlm.nih.gov/pubmed/21946893