Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work)
What I surmise from his hypothesis:
A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.
RNA synthesis inhibited by metribuzin. Is this evidence of metriubuzin acting as a carcinogen inhibiting polymerases?
There are DNA polymerases and RNA polymerases. Think of DNA as the cookbook and RNA as recipes...one polymerase copies the entire cookbook, the other polymerase copies a recipe.
Here is the reference where metribuzin appears to inhibit RNA polymerases.
Use of Isolated Leaf Cells of A butilon theophrasti to Localize the Action of Two Aminotriazinone Herbicidal Derivatives
Knton K. Hatzios
If a virus is present I am suggesting that metribuzin would bind to the viral polymerase stronger.
What I surmise from his hypothesis:
A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.
Cancer cells can make unlimited copies because of the telomere modifications. Co-carcinogenesis requires a virus and a carcinogen to start the cancer. The cancer tumor wears the entry receptor on the surface.
RNA synthesis inhibited by metribuzin. Is this evidence of metriubuzin acting as a carcinogen inhibiting polymerases?
There are DNA polymerases and RNA polymerases. Think of DNA as the cookbook and RNA as recipes...one polymerase copies the entire cookbook, the other polymerase copies a recipe.
Here is the reference where metribuzin appears to inhibit RNA polymerases.
Use of Isolated Leaf Cells of A butilon theophrasti to Localize the Action of Two Aminotriazinone Herbicidal Derivatives
Knton K. Hatzios
If a virus is present I am suggesting that metribuzin would bind to the viral polymerase stronger.
Occup Environ Med. 2005 Nov;62(11):786-92.
Agricultural pesticide use and risk of glioma in Nebraska, United States.
Am J Epidemiol. 2005 May 15;161(10):929-38.
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