Tuesday, November 3, 2015

Autoimmune cross-targeting of the adult brain and the overlaps with other mental illnesses

Autoimmune cross-targeting in the adult brain and overlaps with other brain disorders

Cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  could this apply to these diseases?

 Cotard's syndrome

Cotard's syndrome where the person thinks they have died and they are a zombie.  They have lost sensations, have migraines with auras, catatonic moments, and issues of self starvation. Might not be autoimmune.

The antiviral drug causes cotard's in people with kidney failure

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151143/

http://www.independent.co.uk/news/science/reversing-walking-corpse-syndrome-cotards-syndrome-trigger-found-and-its-a-household-cold-sore-cream-8888670.html

or is it the drug itself causing renal failure?
http://www.shortlist.com/news/common-sore-cream-can-make-you-believe-you-are-dead



Does PDD overlap with Cotard's syndrome?

Cerebellum and catatonia
http://www.researchgate.net/publication/21102475_Cerebellar_atrophy_and_catatonia

PDD catatonic
http://u2pea.free.fr/resources/Lorazepam,-fluoxetine-and-packing-therapy-in-an-adolescent-with-pervasive.pdf

Are these autoimmune issues of the Cerebellum? ataxia, migraine with aura, self starvation, sensory issues. Midlife migraine with aura had higher rates of cerebellum brain lesions later in life

Does Cotard overlap with the sutterella/campylobacteria form of autism? Or is this some other infection at the cerebellum.

Cotard also overlaps depression and schizophrenia: T.gondii has been linked to schizophrenia. Is a parasite involved with cotard?

a parasite of birds called Trichomonas gallinae
http://www.michigan.gov/dnr/0,4570,7-153-10370_12150_12220-27288--,00.html

In people trichomonas vaginalis has been identified as a sexually tramsmitted disease
http://www.ashasexualhealth.org/stdsstis/trichomoniasis/

Has anyone heard of trichomonas with cotard's? Does this occur through the kidney or the cerebellum?

The drooling, the fetid odor, the behavior match...please start testing for this.

Is it the trichomonas infecting the kidney causing the symptoms by damaging the kidney? Not autoimmunity? Does the CMMG go to the cerebellum?

Note that trichomonas has a PNP that works in reverse.  Could this mean that the parasite makes something that acts like CMMG?

Capgray's syndrome

Capgray's where they think their loved ones are an imposter
has lewy body dementia similar to PD

Capgray is linked with hypothyroidism (fungal involvement?)
The condition has prosopagnosia which is impaired facial recognition? 

Strong overlap with Asperger's where the person is unable to recognize facial expressions and Fregoly syndrome where unfamiliar people are thought to be familiar. These diseases are also linked to hypothyroidism.

Asperger's is an issue of the amygdala

 2005 May 1;57(9):991-8.

Functional disconnectivity of the medial temporal lobe in Asperger's syndrome.

Abstract

BACKGROUND:

Autistic spectrum disorders (ASD) are neurodevelopmental conditions that may be caused by abnormal connectivity between brainregions constituting neurocognitive networks for specific aspects of social cognition.

METHODS:

We used three-way multidimensional scaling of regionally parcellated functional magnetic resonance imaging (fMRI) data to explore the hypothesis of abnormal functional connectivity in people with ASD. Thirteen high-functioning individuals with Asperger's syndrome and 13 healthy volunteers were scanned during incidental processing of fearful facial expressions.

RESULTS:

Using permutation tests for inference, we found evidence for significant abnormality of functional integration of amygdala and parahippocampal gyrus (p < .05, false discovery rate [FDR] corrected) in people with Asperger's syndrome. There were less salient abnormalities in functional connectivity of anterior cingulate, inferior occipital, and inferior frontal cortex, but there was no significant difference between groups in whole brain functional connectivity.

Is capgray a fungal infection of a brain region?

 1987 Jan;150:117-21.

Brain imaging in a case of Capgras' syndrome.

Abstract

A patient developed Capgras' syndrome as part of an interictal psychosis of epilepsy; magnetic resonance imaging revealed bilateral subcortical lesions in occipitotemporal and frontal regions. These findings have implications for the postulated association between Capgras' syndrome and neuropsychological deficits, in particular prosopagnosia.


Geschwind Syndrome

Geschwind Syndrome involves the temporal lobe and has hyper religiosity "they feel god". Appears to be linked with temporal lobe epilepsy.

Van Gogh had Geschwind?
Khoshbin asserts that the painter suffered from a type of epilepsy that affects the temporal lobe of the brain. Geschwind had observed a syndrome he called interictal (i.e., between seizures) personality disorder, associated with temporal lobe epilepsy, that includes hypergraphia, hyper-religiosity, unstable sexual behavior, intermittent aggressiveness, and "stickiness" (i.e., clinging behavior).

Epilepsy and whopping cough bacteria
http://www.forbes.com/sites/tarahaelle/2015/11/03/surprise-link-between-epilepsy-and-whooping-cough-whats-the-connection/

DTP vaccine and sudden infant death syndrome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1647245/

 2007 May;4(5):e180.

Association of human herpesvirus-6B with mesial temporal lobe epilepsy.




Alien hand is from frontal lobe lesions therefor it is not autoimmune. Having said that it could be the reason that the frontal lobe form of autism which is the RA and flu form created in pregnancy. Looking now to see if it is the form of autism with the arm flapping and uncontrolled movements.


 1989 Apr;46(4):456-9.

The alien hand syndrome. Clinical and postmortem findings.

Abstract

Two patients had automatonlike movements of their left hands and arms (alien hand syndrome) following damage to the brain. Autopsy findings in one patient demonstrated gunshot wound damage to the medial frontal white matter bilaterally, as well as the corpus callosum, right basal ganglia, internal capsule, and thalamus. The other patient had a ruptured anterior communicating aneurysm, with subsequent resection of the right frontal gyrus rectus. We postulate that this syndrome is due to the combination of a partial callosectomy and mesial frontal lesions.

Autism and movement disorders at birth
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC25000/

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