Candida's quorum sensing, farsenol, and Addison's disease

Microbes talk to each other by secreting compounds to each other.  These compounds have the ability to interfere with the host within whom the infection lives.  Candida secretes farnesol which is known to inhibit P450 enzymes.  This could explain the correlation of addison's disease and candida infections.

Polyglandular Autoimmune syndrome type one strongly associated with candida infections
http://emedicine.medscape.com/article/124183-clinical

Autoimmune thyroid and candida
http://www.ncbi.nlm.nih.gov/pubmed/9039290

Addison's disease has antibodies to 21-hydroxylase

21-hydroxylase is a p450 enzyme
https://en.wikipedia.org/wiki/21-Hydroxylase

Farnesol inhibits cytochromeP450
https://libres.uncg.edu/ir/uncg/f/G_Raner_Farnesol_2002.pdf

liver disease in PAI
http://www.ncbi.nlm.nih.gov/pubmed/9025859

Cytochrome p450 is a hepatic autoantigen in PAI
http://www.ncbi.nlm.nih.gov/pubmed/9141515

P450 antibodies different in PAI and idopathic addison's disease
http://www.jci.org/articles/view/116843

Farnesol is a quorum haulting Candida growth and is secreted by candida
http://aem.asm.org/content/68/11/5459.abstract
http://www.ncbi.nlm.nih.gov/pubmed/16420349

Lymphocytic colitis and polyglandular syndrome one in a patient
http://www.ncbi.nlm.nih.gov/pubmed/?term=microscopic+colitis+polyglandular

Lymphocytic colitis is associated with Candida
http://www.ncbi.nlm.nih.gov/pubmed/23314667

Polyglandular syndrome type two, more commonly found in adults has a strong association with 21-hydroxylase antibodies but not candida?

Could type 2 be different types of fungal infections that also use farnesol for quorum? Is it saccharomyces in the GI tract or candida in the vagina?

The idopathic addison's is associated with PAII
http://www.ncbi.nlm.nih.gov/pubmed/2333733

adult idopathic addison's major antibody is 21-hydroxylase
http://www.ncbi.nlm.nih.gov/pubmed/1511745
http://www.ncbi.nlm.nih.gov/pubmed/8959085

Microscopic colitis, addison's, and skin pigmentation
http://www.ncbi.nlm.nih.gov/pubmed/?term=microscopic+colitis+addison%27s

Patient with ?ulcerative colitis?, vitilgo, addison's (vitilgo is a  hypopigmentation skin disease)
http://www.ncbi.nlm.nih.gov/pubmed/25148815

Hyperpigmentation and PAII
http://www.ncbi.nlm.nih.gov/pubmed/25148815

Hypopigmentation is caused by malassezia (tinea vesicolor)
http://www.ncbi.nlm.nih.gov/pubmed/24320140

Microscopic colitis in woman has been found to have increased autoantibodies and anti-saccharomyces
http://www.ncbi.nlm.nih.gov/pubmed/23776613

note that saccharomyces is currently being used as a probiotic for c.diff
http://iai.asm.org/content/67/1/302.full

Collagenous colitis and addison's disease
http://www.ncbi.nlm.nih.gov/pubmed/9881910
http://www.ncbi.nlm.nih.gov/pubmed/2801683
https://www.jstage.jst.go.jp/article/endocrj1993/45/4/45_4_581/_article


Raynaud's is a mysterious vasodilation issue where when exposed to the cold the person has the opposite response to cold: instead of dilating the vessels of the fingers the blood vessels contract first in a vasospasm

p450 and vasodilation
http://www.ncbi.nlm.nih.gov/pubmed/17572144

Nitric oxide normally inhibits P450
http://www.ncbi.nlm.nih.gov/pubmed/9400024

When the body is exposed to cold temperatures nitric oxide triggers the blood vessels to contract.

What would happen if farsenal is constantly inhibiting p450 ?

Sclerodema and raynaud's
All scleroderma patients have secondary raynaud's....but not all raynaud's have scleroderma

Scloerodema and p450
http://www.ncbi.nlm.nih.gov/pubmed/11263781

How often is raynaud's with addison's disease?

Asthma and p450
http://www.ncbi.nlm.nih.gov/pubmed/15066132