Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/
What I surmise from his hypothesis:
A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.
Cancer cells can make unlimited copies because of the telomere modifications done by the virus.
There are DNA polymerases and RNA polymerases. Think of DNA as the cookbook and RNA as recipes...one polymerase copies the entire cookbook, one makes repairs, and one polymerase copies just a recipe.
If the viral polymerases are inhibited by the carcinogen instead of the host's polymerase then the cancer "stem" cell could be created. The host's polymerases have access to and can make unlimited copies.
In mesothelioma the carcinogen that has been linked is asbestos and the virus which has been linked is sv40.
Gangliosides are receptors to sv40http://www.ncbi.nlm.nih.gov/pmc/articles/PMC202381/
Ganglioside GM2 is increased in Mesothelioma
http://www.ncbi.nlm.nih.gov/pubmed/25421609
sv40 induces mesothelioma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886912/
asbestos and mesothelioma
http://www.ncbi.nlm.nih.gov/pubmed/18671157
Asbestos inhibiting polymerases
http://www.ncbi.nlm.nih.gov/pubmed/21543585
No comments:
Post a Comment