Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications : Tyrosol as a quorum of Trichophyton? connections to discord lupus and vitiligo? ALS and a toxin secreting Trichophyton?

other possible fungal infections: Malassezia or saccharomyces or Cryptococcus neoformans

Malassezia was connected to seborrheic dermatitis
http://www.ncbi.nlm.nih.gov/pubmed/26786542
http://www.ncbi.nlm.nih.gov/pubmed/11092380

Saccharomyces infections are typically found in the gut or lungs (baker's asthma)

Aspergillus typically infects the lungs and guts (previously pondered a bulb plant allergy with this: onions, lilies, garlic) Aspergillus is the most common fungus attacking the brain.

Note that aspergillus has symbiotic relationships with bacteria
http://www.ncbi.nlm.nih.gov/pubmed/26856310

Candida also has a symbiotic relationships with bacteria

staph and candida together as growing partners
http://www.bioone.org/doi/abs/10.1893/0005-3155-84.1.30
http://www.ncbi.nlm.nih.gov/pubmed/26262843

Lupus and staph linked
http://www.huffingtonpost.com/2012/08/08/lupus-risk-staph-bacteria_n_1758258.html

Staph makes a pigment with egg and milk
The allergies associated with eczema and lupus could be because of staph infections developing pigment when it sees egg or milk.

Does staph grow with Trichonphyton too? Egg and milk allergies seem to exist with vitiligo.

Note that a previous hypothesis on this blog suggests that gluten sensitivity comes from infections crossing barriers, intestine, lung or the blood brain barrier. Only when the fungal infection has broken through one does gluten sensitivity occur. (when T.gondi breaks through the intestine gluten sensitivity occurs in a similar manner)

tangent thought

Sour cream inhibits tyrosinase
Does sour cream confuse trichophyton? Could eating sour cream help limit the growth of the fungus or would it make the vitiligo worse?
Can applying sour cream to freckles can make them disappear?

This next part might become it's own blog post soon.

I have looked at trichophyton before as a connection to ALS. It could be one of the other fungal infections though.

Is ALS an autoimmune cross-targeting disease of trichophyton or similar fungus and a virus? NO mulitiple sclerosis is an autoimmune attack on the nerves. ALS is the "breakdown of the nerves"

Can infections of the feet explain the sport association of ALS? Lou Gehrig's disease
Trichophyton is the most common skin fungus and causes athletes foot.
http://www.ncbi.nlm.nih.gov/pubmed/18578874

Trichophyton has a wood rot variety: T. rubrum

This could be found in rotting beaver dams....which might explain the ALS clusters around lakes in north America.
http://link.springer.com/article/10.3839%2Fjksabc.2010.026#page-1

Lupus can overlap amyotrophic lateral sclerosis (ALS)
http://www.ncbi.nlm.nih.gov/pubmed/11908583
http://www.ncbi.nlm.nih.gov/pubmed/15200286
http://www.shmabstracts.com/abstract/amyotrophic-lateral-sclerosisals-in-a-patient-with-systemic-lupus-erythematosus-sle/

so how would a skin fungus cause nerves to die?

amyloid beta is in skin of ALS which means the mitochondrias are destroyed
http://www.ncbi.nlm.nih.gov/pubmed/11041332

Some of these fungal infections that live on us create toxins: aflatoxin made my aspergillus damages the mitochondria

Aflatoxin damages the mitochondria
http://researchspace.ukzn.ac.za/xmlui/handle/10413/7851

Aflatoxin like compounds are made by some dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum

Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf

High rates of trichophyton concentricum on Solomon children (close to guam and makes you wonder if both areas share this infection)
https://www.researchgate.net/publication/281516255_Trichophyton_concentricum_in_skin_lesions_in_children_from_the_Salomon_Islands

ALS and lakes in new england
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922844/

Has T.concetricum appeared in these lakes?

So the questions we need to solve: which fungus matches up with which disorders?

How much tyrosol does pityriasis versicolor make? another pigment loss skin disorder

In addition to farnesol, the other known fungal QSMs are all alcohols derived from aromatic amino acids tyrosine (tyrosol), phenylalanine (phenylethanol) and tryptophan (tryptophol).
https://mmy.oxfordjournals.org/content/50/4/337.full#ref-13

Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications

Friday, February 19, 2016

Tyrosol as a quorum of Trichophyton? connections to discord lupus and vitiligo? ALS and a toxin secreting Trichophyton?

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