Analyzing the overlap of anti-phospholipid syndrome, strep, mycobacteria, campylobacteria, mycoplasmas,and alopecia

This page is just beginning...

Anti-phospholipids appear to be generated by mycobacteria, strep, mycoplasmas, and campylobacteria.

Anti-phospholipid antibodies in autoimmune diseases: lupus, gullian barre, MS, psoriatic arthritis,
http://www.ncbi.nlm.nih.gov/pubmed/2094193
http://www.japi.org/march_2010/Article_08.pdf

Antiphospholipid antibodies can cross-react with platelet glycoproteins
http://www.ncbi.nlm.nih.gov/pubmed/8713797

The different infections have different disease and autoimmune cross-targeting families but they all have the ability to generate anti-phospholipids . It may be the one thing these infections have in common.

Strep

strep and anti-cardiolipin
http://ard.bmj.com/content/61/4/374.full

rheumatic fever and anti-phospholipid
http://www.hindawi.com/journals/jir/2014/614591/
http://rheumatology.oxfordjournals.org/content/45/7/833.short
http://www.ncbi.nlm.nih.gov/pubmed/22408372

antiphospholipid and tics
http://www.ncbi.nlm.nih.gov/pubmed/16538618

chorea and antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/1813192

alopecia and strep
http://www.ncbi.nlm.nih.gov/pubmed/20525487

strep and antiphospholipid antibodies
http://www.ncbi.nlm.nih.gov/pubmed/21985124

Behcets has anti-cardiolipin and is associated with strep
http://angelabiggs.blogspot.com/2013/04/behcets-disease.html

Behcets and mitochondria polymorphisms
https://acrabstracts.org/abstract/genetic-association-of-mitochondrial-dna-polymorphisms-with-behcets-disease-in-a-korean-population/

HLA-B5, Behcets and autoimmune disease
https://acrabstracts.org/abstract/hla-b51-and-possible-associated-autoimmune-disorders-other-than-behcets-disease-a-retrospective-cohort-study/

Behcet's and herpes simplex 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857840/

erythema nodosum and behcets
https://www.ncbi.nlm.nih.gov/pubmed/22504656

TLR9 and behcet's
https://www.ncbi.nlm.nih.gov/pubmed/23237868

TLR7 and Behcets ocular? is this with a different virus?
https://www.ncbi.nlm.nih.gov/pubmed/25650422

Mycobacteria

mycobacteria and antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/23910993

mycobacteria and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pubmed/15967589

anti-cardiolipin and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757429/

antiphospholipids and type 2 diabetes
http://www.ncbi.nlm.nih.gov/pubmed/20446442

psoriatic arthritis and antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/2778757

The skin disorder psoriasis and chron's disease have strong associations with these too.

Note that there is an earlier post talking about the quorum of mycobacteria possibly causing the type 2 diabetes and fatty liver disease.

Note that psoriasis has been connected to MS and some forms of PANDAS.

Takayasu and mycobacteria
http://angelabiggs.blogspot.com/2013/10/takayasus-caused-by-autoimmune-cross.html

APL and Takayasu
http://journals.lww.com/md-journal/Abstract/2015/12210/Takayasu_Arteritis_With.32.aspx

is this Takayasu an unusual type of mycobacteria?


Campylobacteria/sutterella
(these are very similar bacterias and were once lumped together)

Antiphospholipids and babies with autism
http://ard.bmj.com/content/early/2012/05/14/annrheumdis-2011-201167.full.pdf

sutterella and autism
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828002/

guillain barre and campylobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88896/

guillain barre and antiphospholipids
http://rheumatology.oxfordjournals.org/content/42/2/200.full

campylobacteria and sutterella are bacterial infections that typically cross over from the intestine

Mycoplasma

mycoplasma and anti-phospholipids
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426843/
http://www.ncbi.nlm.nih.gov/pubmed/22696636

adhesion glucoprotein on mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/9695283

lupus and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/26744491

RA and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/19650889

 Xa antibodies in Lupus but not the rheumatic strep induced
http://www.readcube.com/articles/10.1186%2Fs13075-015-0568-7

thrombiosis and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/21378521

adenovirus and mycoplasma then antiphospholipids
http://www.ncbi.nlm.nih.gov/pubmed/24598069


These infections can cross-target with viral infections and trigger the destructive form of autoimmune disease where self tissues are attacked.  I call the condition autoimmune cross-targeting.

Autoimmune Cross-targeting hypothesis:  2 simultaneous infections on one target triggers autoimmunity.  One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.

guillain barre could be: campylobacteria and a flavivirus at the peripheral nerves

alopecia could be: mycobacteria at the scalp and then epstein barr

Pandas could be : strep or mycobacteria with the flu at the basal ganglia

MS could be: mycobacteria with herpes zoster on central nerves

Added November 2016 

antiphospholipid syndrome has been associated with HLA-DR5 and HLA-DR12

HLA-DR 12 connects to Rubella (german measles)

 Rubella antibodies and antiphospholipid
https://www.ncbi.nlm.nih.gov/pubmed/22641586
https://www.ncbi.nlm.nih.gov/pubmed/19880561