Tuesday, October 8, 2013

Takayasus caused by autoimmune cross-targeting?

Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease.  One infection marks the outside while another marks the inside...only then does the immune system become confused and attack.


Takayasu and lupus?are these actually Kawasaki patients?
http://www.ncbi.nlm.nih.gov/pubmed/1351317
http://link.springer.com/article/10.1007%2Fs00296-009-1133-y#page-1
http://www.ncbi.nlm.nih.gov/pubmed/10380843
http://www.ncbi.nlm.nih.gov/pubmed/14986087

Takayasu's and mycobacteria
TA and tuberculosis are chronic granulomatous diseases
http://www.ncbi.nlm.nih.gov/pubmed/8839810
http://www.ncbi.nlm.nih.gov/pubmed/10371844 

type 2 diabetes patients with Takayasu (therefore the virus cannot be common)
http://www.ehealthme.com/cs/type+2+diabetes+mellitus/takayasu%27s+arteritis

confusing review (more common in women...dimorphic supports mycobacteria)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232509/

crohn's and Takayasu (strong association implicates mycobacteria)
http://www.ncbi.nlm.nih.gov/pubmed/12746644
http://www.ncbi.nlm.nih.gov/pubmed/11907362
http://www.ncbi.nlm.nih.gov/pubmed/33869
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722706/
http://practicalgastro.com/pdf/March09/JudahArticle.pdf
http://www.jmedicalcasereports.com/content/2/1/87

The BCG vaccine? (mycobacteria vaccine)
http://www.ncbi.nlm.nih.gov/pubmed/7901414 (erythema nodosum induced too?)
http://www.ncbi.nlm.nih.gov/pubmed/8569543


erythema nodosum and mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/23650522

looking for virus now: maybe this is not autoimmune?

the genetic susceptibility  found for Takayasu involve the t-cell mail box the HLA?
http://www.news-medical.net/news/20130730/Researchers-uncover-genetics-behind-what-makes-some-people-susceptible-to-Takayasu-arteritis.aspx      That would indicate a virus because HLA tells the t-cell what is inside...if a virus infects a piece would end up in the mailbox...huh.

found it!  Hepatitis B and Takayasu
http://www.ncbi.nlm.nih.gov/pubmed/11361200
http://www.ncbi.nlm.nih.gov/pubmed/7901414

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