Tuesday, October 8, 2013

Kawasaki is it autoimmune Cross-targeting triggered? Bcells infected by mycoplasmas?

 Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease.  One infection marks the outside while another marks the inside...only then does the immune system become confused and attack.

Kawasaki is autoimmune:
http://link.springer.com/article/10.1007%2Fs00296-013-2770-8

Mycoplasma pneumonia and kawasaki
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511717/
http://www.ncbi.nlm.nih.gov/pubmed/21042274
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120998/
http://www.hindawi.com/crim/medicine/2011/606920/
http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.2001.tb00810.x/abstract

Lupus and Kawasaki (lupus could be red blood cells infected by mycoplasmas see earlier posts)
http://www.ncbi.nlm.nih.gov/pubmed/22868216
http://www.ncbi.nlm.nih.gov/pubmed/3379628
http://treato.com/Kawasaki+Disease,Lupus/?a=s

The infection of Bcell lines by mycoplasmas (Lymph nodes are the hubs for Bcells)
http://www.ncbi.nlm.nih.gov/pubmed/16054780

Kawasaki and hepatitis B
http://www.ncbi.nlm.nih.gov/pubmed/14677029
http://www.ncbi.nlm.nih.gov/pubmed/14521027
http://cpj.sagepub.com/content/early/2015/01/29/0009922815569206

Kawasaki and other polyomaviruses
http://www.ncbi.nlm.nih.gov/pubmed/9622713

EBV virus (mono) and Kawasaki
http://jid.oxfordjournals.org/content/162/5/1215.extract
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC499744/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687726/
http://www.ncbi.nlm.nih.gov/pubmed/7871990
http://pediatrics.aappublications.org/content/73/3/413 

I am considering a separate Kawasaki with Yersinia.....to be continued.  This would have reactive arthritis, graves based thyroiditis (the enlarged thyroid), and  mesenteric lymphadenitis.

Note that I think it is the target that is more relevant then the infection...both Yersinia and mycoplasmas can cause the disease...with EBV.


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