Aflatoxin is a fungal toxin that binds to microtubules and possibly causes the tau proteins to become phosphorylated.
Tau stabilizes the microtubules (railroad tracks) that the mitochondrias move on. Apparently when they, Tau proteins, are phosphorylated the mitochondrias can't move.
Both Pick's disease and ALS have nerve damage through microtubule dysfunction and increased Tau protein phosphorylation.
Pick's disease has been connected to frontal lobe dementia which has been found with Asperger's disease .
Aspergillus makes aflatoxin: ALS suspect makes an aflatoxin like compound
T.concetricum makes an aflatoxin-like compound: Pick's disease
Tau protein as a marker for ALS
https://ftd.med.upenn.edu/uploads/media_items/phosphorylated-tau-candidate-biomarker-for-amyotrophic-lateral-sclerosis.original.pdf
Tau and phosphorylation under starvation
http://www.sciencedirect.com/science/article/pii/S0014579307001068
Is this to stop the mitochondria from moving when food is scarce?
Earlier blog post connected ALS to Trichophyton concetricum and then looked at the aflatoxin-like compound it can secrete as the reason for the nerve death in ALS.
http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html
phosphorylation of tau and mitochondrial dysfunction in alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/23936615
Aflatoxin damages the mitochondria
http://researchspace.ukzn.ac.za/xmlui/handle/10413/7851
Aflatoxin like compounds are made by some dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum
Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf
Pick's disease is a rare form of dementia and phosphorylated tau proteins accumulate in the front temporal lobe
ALS associated protein found in Pick's disease
http://www.ncbi.nlm.nih.gov/pubmed/23888880
Phosphorylated tau as a marker for ALS
http://www.ncbi.nlm.nih.gov/pubmed/24492862
Tau and the mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/21872849
aflatoxin and reduced growth
http://ije.oxfordjournals.org/content/32/4/556.full
ALS and higher cancer rates
http://ecancer.org/news/7450-higher-incidence-of-cancer-among-patients-with-amyotrophic-lateral-sclerosis.php
polymerase stimulation by microtubule associated proteins : tau included
http://www.ncbi.nlm.nih.gov/pubmed/1742279
aflatoxin inhibits polymerase indirectly by binding chromatin
http://www.ncbi.nlm.nih.gov/pubmed/3128406
http://www.ncbi.nlm.nih.gov/pubmed/2419004
ALS and microtubule breakdown theory
http://www.wildcat.arizona.edu/article/2015/02/cellular-highway-breaks-down-in-als
als and microtubules..genetic?
http://onlinelibrary.wiley.com/store/10.1046/j.1471-4159.2003.01505.x/asset/j.1471-4159.2003.01505.x.pdf?v=1&t=ilbs1xxy&s=3327c88bf2325881a0efd564c1d92ffa84dbcd02
A microtubule theme seems to be developing. The aflatoxin like toxin that the trichophyton secretes in ALS must be acting on the microtubules.
overlap of Frontal lobe dementia and ALS with a non tau but other genetic link
http://archneur.jamanetwork.com/article.aspx?articleid=785491
Could it be that picks's disease is associated with aflatoxin from an aspergillus infection of the frontal lobe while ALS is trichonphyton's aflatoxin like compound?
People with asperger's get pick's disease at higher rates?
Aspergillus and frontal lobe
http://www.ncbi.nlm.nih.gov/pubmed/7520548
http://link.springer.com/article/10.1007%2FBF01808927#page-1
Locations of aspergillus infections
http://www.turner-white.com/pdf/hp_apr99_aspergill.pdf
aspergillus and it's quorum might connect to asperger's
http://angelabiggs.blogspot.com/2016/02/aspergillus-quorum-is-oxylipins-could.html
asperger's and frontal lobe dementia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379728/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267505/
http://www.aspergerpartner.com/wp-content/uploads/2014/08/Does-ASD-get-worse-with-with-age.pdf
Tau stabilizes the microtubules (railroad tracks) that the mitochondrias move on. Apparently when they, Tau proteins, are phosphorylated the mitochondrias can't move.
Both Pick's disease and ALS have nerve damage through microtubule dysfunction and increased Tau protein phosphorylation.
Pick's disease has been connected to frontal lobe dementia which has been found with Asperger's disease .
Aspergillus makes aflatoxin: ALS suspect makes an aflatoxin like compound
T.concetricum makes an aflatoxin-like compound: Pick's disease
Tau protein as a marker for ALS
https://ftd.med.upenn.edu/uploads/media_items/phosphorylated-tau-candidate-biomarker-for-amyotrophic-lateral-sclerosis.original.pdf
Tau and phosphorylation under starvation
http://www.sciencedirect.com/science/article/pii/S0014579307001068
Is this to stop the mitochondria from moving when food is scarce?
Earlier blog post connected ALS to Trichophyton concetricum and then looked at the aflatoxin-like compound it can secrete as the reason for the nerve death in ALS.
http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html
phosphorylation of tau and mitochondrial dysfunction in alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/23936615
Aflatoxin damages the mitochondria
http://researchspace.ukzn.ac.za/xmlui/handle/10413/7851
Aflatoxin like compounds are made by some dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum
Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf
Pick's disease is a rare form of dementia and phosphorylated tau proteins accumulate in the front temporal lobe
ALS associated protein found in Pick's disease
http://www.ncbi.nlm.nih.gov/pubmed/23888880
Phosphorylated tau as a marker for ALS
http://www.ncbi.nlm.nih.gov/pubmed/24492862
Tau and the mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/21872849
aflatoxin and reduced growth
http://ije.oxfordjournals.org/content/32/4/556.full
ALS and higher cancer rates
http://ecancer.org/news/7450-higher-incidence-of-cancer-among-patients-with-amyotrophic-lateral-sclerosis.php
polymerase stimulation by microtubule associated proteins : tau included
http://www.ncbi.nlm.nih.gov/pubmed/1742279
aflatoxin inhibits polymerase indirectly by binding chromatin
http://www.ncbi.nlm.nih.gov/pubmed/3128406
http://www.ncbi.nlm.nih.gov/pubmed/2419004
ALS and microtubule breakdown theory
http://www.wildcat.arizona.edu/article/2015/02/cellular-highway-breaks-down-in-als
als and microtubules..genetic?
http://onlinelibrary.wiley.com/store/10.1046/j.1471-4159.2003.01505.x/asset/j.1471-4159.2003.01505.x.pdf?v=1&t=ilbs1xxy&s=3327c88bf2325881a0efd564c1d92ffa84dbcd02
A microtubule theme seems to be developing. The aflatoxin like toxin that the trichophyton secretes in ALS must be acting on the microtubules.
overlap of Frontal lobe dementia and ALS with a non tau but other genetic link
http://archneur.jamanetwork.com/article.aspx?articleid=785491
Could it be that picks's disease is associated with aflatoxin from an aspergillus infection of the frontal lobe while ALS is trichonphyton's aflatoxin like compound?
People with asperger's get pick's disease at higher rates?
Aspergillus and frontal lobe
http://www.ncbi.nlm.nih.gov/pubmed/7520548
http://link.springer.com/article/10.1007%2FBF01808927#page-1
Locations of aspergillus infections
http://www.turner-white.com/pdf/hp_apr99_aspergill.pdf
aspergillus and it's quorum might connect to asperger's
http://angelabiggs.blogspot.com/2016/02/aspergillus-quorum-is-oxylipins-could.html
asperger's and frontal lobe dementia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379728/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267505/
http://www.aspergerpartner.com/wp-content/uploads/2014/08/Does-ASD-get-worse-with-with-age.pdf
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