I have been hypothesizing that flaviviruses use melanocortin receptors.
melatonin protecting against flavivirus infection through competition with the receptors?
http://www.ncbi.nlm.nih.gov/pubmed/14962057
The ACTH receptor is the melanocortin2 receptor.
Zika was found in the amniotic fluid
http://www.dailymail.co.uk/health/article-3451984/Zika-cross-placenta-infect-unborn-babies-Traces-virus-amniotic-fluid-surrounding-two-fetuses-diagnosed-microcephaly.html
ACTH and the placenta
Placenta makes ACTH
http://www.nature.com/nature/journal/v254/n5501/abs/254620b0.html
placenta transports ACTH
http://press.endocrine.org/doi/abs/10.1210/jcem-39-3-440
Are there ACTH receptors on the placenta? yes
http://press.endocrine.org/doi/abs/10.1210/jcem-39-3-440
http://www.ncbi.nlm.nih.gov/pubmed/15781985
Note that Zika might be using the ACTH receptors
http://angelabiggs.blogspot.com/2016/01/does-zika-virus-use-melanocortin.html
Zika was found in placenta tissue
http://www.cdc.gov/mmwr/volumes/65/wr/mm6506e1.htm
since the placenta is made up of trophoblast cells one would think that zika would infect the trophoblast cells but the mouse model trophoblasts cells did not get infected?? i am trying to find the actual research paper because this doesn't sound right
https://www.sciencedaily.com/releases/2016/04/160405161124.htm
Apparently the Zika can get into the placenta cells but they don't replicate there.
Note that the placenta cells contain a specific inhibitor of mammalian retroviral RNA-directed DNA polymerase (these are not retroviruses but it is not unfathomable that other similar inhibitors are present)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC319194/
Does Zika there move just like ACTH through the placenta? does the hormone ACTH have a fast route?
So as an autoimmune blog how is this relevant ? Zika can trigger guillian barre through cross-targeting.
http://angelabiggs.blogspot.com/2016/01/is-guillian-barre-caused-by-autoimmune.html
melatonin protecting against flavivirus infection through competition with the receptors?
http://www.ncbi.nlm.nih.gov/pubmed/14962057
Zika was found in the amniotic fluid
http://www.dailymail.co.uk/health/article-3451984/Zika-cross-placenta-infect-unborn-babies-Traces-virus-amniotic-fluid-surrounding-two-fetuses-diagnosed-microcephaly.html
ACTH and the placenta
Placenta makes ACTH
http://www.nature.com/nature/journal/v254/n5501/abs/254620b0.html
placenta transports ACTH
http://press.endocrine.org/doi/abs/10.1210/jcem-39-3-440
Are there ACTH receptors on the placenta? yes
http://press.endocrine.org/doi/abs/10.1210/jcem-39-3-440
http://www.ncbi.nlm.nih.gov/pubmed/15781985
Note that Zika might be using the ACTH receptors
http://angelabiggs.blogspot.com/2016/01/does-zika-virus-use-melanocortin.html
Zika was found in placenta tissue
http://www.cdc.gov/mmwr/volumes/65/wr/mm6506e1.htm
since the placenta is made up of trophoblast cells one would think that zika would infect the trophoblast cells but the mouse model trophoblasts cells did not get infected?? i am trying to find the actual research paper because this doesn't sound right
https://www.sciencedaily.com/releases/2016/04/160405161124.htm
Apparently the Zika can get into the placenta cells but they don't replicate there.
Note that the placenta cells contain a specific inhibitor of mammalian retroviral RNA-directed DNA polymerase (these are not retroviruses but it is not unfathomable that other similar inhibitors are present)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC319194/
Does Zika there move just like ACTH through the placenta? does the hormone ACTH have a fast route?
So as an autoimmune blog how is this relevant ? Zika can trigger guillian barre through cross-targeting.
http://angelabiggs.blogspot.com/2016/01/is-guillian-barre-caused-by-autoimmune.html
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