Tuesday, March 29, 2016

ACTH, the placenta...and Zika

I have been hypothesizing that flaviviruses use melanocortin receptors.

melatonin protecting against flavivirus infection through competition with the receptors?
http://www.ncbi.nlm.nih.gov/pubmed/14962057

The ACTH receptor is the melanocortin2 receptor.

Zika was found in the amniotic fluid
http://www.dailymail.co.uk/health/article-3451984/Zika-cross-placenta-infect-unborn-babies-Traces-virus-amniotic-fluid-surrounding-two-fetuses-diagnosed-microcephaly.html

ACTH and the placenta

Placenta makes ACTH
http://www.nature.com/nature/journal/v254/n5501/abs/254620b0.html

placenta transports ACTH
http://press.endocrine.org/doi/abs/10.1210/jcem-39-3-440

Are there ACTH receptors on the placenta? yes
http://press.endocrine.org/doi/abs/10.1210/jcem-39-3-440
http://www.ncbi.nlm.nih.gov/pubmed/15781985

Note that Zika might be using the ACTH receptors
http://angelabiggs.blogspot.com/2016/01/does-zika-virus-use-melanocortin.html

Zika was found in placenta tissue
http://www.cdc.gov/mmwr/volumes/65/wr/mm6506e1.htm

since the placenta is made up of trophoblast cells one would think that zika would infect the trophoblast cells but the mouse model trophoblasts cells did not get infected?? i am trying to find the actual research paper because this doesn't sound right
https://www.sciencedaily.com/releases/2016/04/160405161124.htm

Apparently the Zika can get into the placenta cells but they don't replicate there.

Note that the placenta cells contain a specific inhibitor of mammalian retroviral RNA-directed DNA polymerase  (these are not retroviruses but it is not unfathomable that other similar inhibitors are present)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC319194/

 Does Zika there move just like ACTH through the placenta? does the hormone ACTH have a fast route?


So as an autoimmune blog how is this relevant ? Zika can trigger guillian barre through cross-targeting.
http://angelabiggs.blogspot.com/2016/01/is-guillian-barre-caused-by-autoimmune.html

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