Friday, March 18, 2016

Tau bodies compared to Lewy bodies: Tau from aspergillus and alpha-synuclein from mycobacteria

If aspergillus is producing aflatoxin and causing the tau protein lewy bodies then when aspergillus exists in the intestine one should have nerve issues and tau there.

Earlier post connecting tau to aspergillus
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html

Having IBS increase the chances of having nerve damage
https://www.sciencedaily.com/releases/2007/04/070423185730.htm

Restless leg syndrome and IBS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479257/

Small fiber neuropathy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086960/

neuropathy compared to restless leg syndrome
http://www.clinicaladvisor.com/the-waiting-room/restless-legs-syndrome-neuropathy-differences/article/402886/

Which does it cause: RLS or a type of neuropathy?

If aspergillus causes one type of colitis which type has nerve damage?

Intestinal ganglioneurmatosis (damaged nerves and the presence of TAU protein)
https://www.researchgate.net/publication/10837617_Intestinal_ganglioneuromatosis_diagnosed_in_adult_patients

diffuse intestinal ganglioneurmatosis mimicking crohn's ??? does it not look like colitis ?
http://www.ajronline.org/doi/full/10.2214/ajr.182.5.1821166

a crohn's with polyps ? this type does exist..
http://www.ncbi.nlm.nih.gov/pubmed/3691406
http://www.ncbi.nlm.nih.gov/pubmed/12031089
http://www.ncbi.nlm.nih.gov/pubmed/3717497

RLS and asperger's

http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_articulo=13154274&pident_usuario=0&pcontactid=&pident_revista=295&ty=99&accion=L&origen=zonadelectura&web=www.elsevier.es&lan=es&fichero=295v25n06a13154274pdf001_2.pdf

note that in the book "my asperger soul" the writer found that he had hundreds of colon polyps

https://books.google.com/books?id=Gy7Hys5XXIMC&pg=PA205&lpg=PA205&dq=asperger%27s+polyps&source=bl&ots=ERrhdAtsoB&sig=eYbYg4hGGC80pZENAqhjO3Iqk2Q&hl=en&sa=X&ved=0ahUKEwi2tsTYnsvLAhWLzoMKHaFPAU0Q6AEITzAJ#v=onepage&q=asperger's%20polyps&f=false

lewy body dementia and restless leg: dopamine medication helped both?
http://www.ncbi.nlm.nih.gov/pubmed/24528871
http://www.ncbi.nlm.nih.gov/pubmed/22849331

autopsy of RSL showed no TAU or lewy bodies ? I would have thought it would be there
http://www.ncbi.nlm.nih.gov/pubmed/15197711

aflatoxin and dopamine
https://www.researchgate.net/publication/20744418_Effect_of_repeated_dietary_exposure_of_aflatoxin_B1_on_brain_biogenic_amines_and_metabolites_in_the_rat

no TAU on brain or spinal with RLS?
http://www.ncbi.nlm.nih.gov/pubmed/15197711

Note that there are 4 types of frontal lobe dementia and for TAU proteins we are looking at a specific one.

Semantic dementia: "the loss of words" Which has been strongly linked to viral infections

Behavioral variant FTD:  which has the loss of social behavior, conduct, and impulse control. Which has been linked to Pick's disease where Tau proteins form Lewy bodies.

Progressive nonfluent aphasia FTD:  which involves speech production, stuttering, and apraxia. This form has been linked to blood clots creating a stroke

The 4th type is connected with ALS, amyotrophic lateral sclerosis.

Aflotoxin like compounds are made by some other dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum

Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf

Looking at other lewy body brain diseases like parkinson's one realizes that the content of the lewy body is different.

Parkinson's had alpha-synuclein in their gut (a different type of lewy body) as well as in the brain
http://www.livescience.com/36354-parkinsons-disease-colonoscopy-diagnosis.html

alpha-synuclein has also been found in the blood of type 2 diabetes
http://www.nature.com/articles/srep12081

alpha-synuclein is also found in multiple sclerosis which could involve mycobacterias
http://www.ncbi.nlm.nih.gov/pubmed/19151622

cGMP increases the amount of alpha-synuclein
http://eurekamag.com/research/034/334/034334017.php

cGMP and synuclein (functional connections)
https://www.ncbi.nlm.nih.gov/pubmed/18064424
https://www.ncbi.nlm.nih.gov/pubmed/17610578

Parkinson's, type 2 diabetes, fatty acid liver disease, crohn's, and psoriasis were previously connected to Mycobacterias on this blog.  The quorum of mycobacteria is cGMP. (which on  a previous blog post was connected to type 2 diabetes and fatty liver disease)

Thus the alpha-synuclein seen in these cases could be caused by the high concentraiton of cGMP made by mycobacterias as they attempt to talk to each other.


No comments:

Post a Comment