Autoimmune Cross-targeting hypothesis: 2 simultaneous infections on one target triggers autoimmunity. One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.
In the case of Guillain barre: camypylobacteria infection is on the outside and a flavivirus marks the inside.
The Campylobacteria Jejuni infection begins in the gut but triggers the autoimmune paralysis of the legs when it crosses the intestine and get into the peripheral nervous system.
references of Guillain barre and campylobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258
http://www.ncbi.nlm.nih.gov/pubmed/23514735
http://www.ncbi.nlm.nih.gov/pubmed/23528202
The Campylobacteria Jejuni infection begins in the gut but triggers the autoimmune paralysis of the legs when it crosses the intestine and get into the peripheral nervous system.
references of Guillain barre and campylobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258
http://www.ncbi.nlm.nih.gov/pubmed/23514735
http://www.ncbi.nlm.nih.gov/pubmed/23528202
Zika virus Guillain barre
guillain barre and dengue
there are more references on pubmed
guillain barre and chikungunya
chikunguna is called dengue in the Americas????
west nile and guillain barre
http://www.ncbi.nlm.nih.gov/pubmed/22461779
Note that Herpes viruses like herpes zoster infect nerves too and can trigger the autoimmune cross-targeting. The key is that the campylobacteria must be there on the outside when a virus infects the inside of the nerve.
or....there can be a type of guillian barre triggered by mycoplasmas instead of camyplobacteria
http://www.ncbi.nlm.nih.gov/pubmed/?term=guillian+barre+mycoplasma
mycoplasmas have strong associations with Rheumatoid arthritis
Campylobacteria/sutterella are fecal bacterias found in areas where the flooding can cause sewer to enter the water supply or where milk is contaminated by fecal matter and milk is drunk raw
fecal and milk
http://www.cdc.gov/mmwr/volumes/65/wr/pdfs/mm6512.pdf
Note that Herpes viruses like herpes zoster infect nerves too and can trigger the autoimmune cross-targeting. The key is that the campylobacteria must be there on the outside when a virus infects the inside of the nerve.
or....there can be a type of guillian barre triggered by mycoplasmas instead of camyplobacteria
http://www.ncbi.nlm.nih.gov/pubmed/?term=guillian+barre+mycoplasma
mycoplasmas have strong associations with Rheumatoid arthritis
Campylobacteria/sutterella are fecal bacterias found in areas where the flooding can cause sewer to enter the water supply or where milk is contaminated by fecal matter and milk is drunk raw
fecal and milk
http://www.cdc.gov/mmwr/volumes/65/wr/pdfs/mm6512.pdf
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