Saturday, January 9, 2016

Myasthenia gravis. Are there 2 types because 2 different viruses trigger it? Are flaviviruses like zika involved?

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack. A virus marking the inside of the thymus and an infection like mycoplasmas marking the outside for myasthenia gravis

Myasthenia gravis and RA

mycoplasmas and RA
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1006269/

could be Stentorophomonas  instead of mycoplasmas which would explain the overlap with fibromyalgia and pituitary tumors.

 Ocular MG (eyes are weak) 

 People with ocular MG are slightly more likely to have seronegative MG (no measurable acetylcholine receptor antibodies) compared with people with generalized MG

Myasthenia gravis, ACTH antibodies, conjunctivitis
http://www.ncbi.nlm.nih.gov/pubmed/15465082

Flaviviruses like zika virus infect using ACTH receptors...symptoms of Zika infection include conjunctivitis

Myasthenia gravis after west nile
http://www.medscape.com/viewarticle/807230

West nile, yellow fever, dengue, and Zika are a few examples of  flaviviruses

The thymus has ACTH receptors
http://www.ncbi.nlm.nih.gov/pubmed/25733567

Late onset MG and HLA-DR15
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348874/


Generalized MG (trunk, arms and legs are weak)

Enteroviruses use acetylocholine receptors

Examples of enteroviruses : d68, coxsackie viruses, polio virus, and  echoviruses

polio virus and thymus
http://www.ncbi.nlm.nih.gov/pubmed/20368632

Acetylcholine receptors, thymus and myasthenia gravis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1536815/
http://www.ncbi.nlm.nih.gov/pubmed/182897

HLA-DR3, early onset MG, and acetylcholine
http://www.jimmunol.org/content/167/2/1118.full





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4 comments:

  1. LillyFebruary 2, 2016 at 4:55 PM

    Thank you for this info! I'm fairly new to Myasthenia. Diagnosed in June of 2015. I'm doing pretty good now. I'm wondering if this has to do with my Trip to Aruba in Nov 2014 when my first ocular MG emerged?? Docs did run tests on West nile and Lyne disease which were both negative.

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  2. Biggs HypothesesFebruary 10, 2016 at 5:37 PM

    How soon did they run the tests? These viruses only stay in your system 2 weeks but they can trigger the autoimmune when they are there. Do you remember getting bitten by a mosquito ?

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  3. LillyFebruary 29, 2016 at 6:06 PM

    I came back from Aruba Nov 2014, I had double vision went to my optamologist. He told me it was 6th nerve palsy. Fast forward to Feb 2015, was shoveling, had pain and sciatica next day. Orhtopedic took xray, I had 2 herniated discs. Back and forth to Physical therapy and it was improving until about mid April 2014. Went to see Pain mgmnt doc for epidural for the sciatica. He checked my reflexes on both sides, my left arms and legs were both weak. Went to neurologist next day. She hospitalized me in June for 5 days to run tests. She suspected MS. MG came up positive. I'm am currently getting plasmapheresis and on Cellcept.
    So, if it was ZIKA, they could not run tests now. Hospital ran tests for Lyme and West nile. Both Negative.

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  4. Natural Herbs ClinicMay 22, 2017 at 4:37 AM

    This comment has been removed by a blog administrator.

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