Wednesday, January 20, 2016

Multiple sclerosis and seizures : autoimmune cross-targeting with different viruses

Multiple sclerosis and seizures have long been known to manifest at times together.
http://www.ncbi.nlm.nih.gov/pubmed/22258045

Autoimmune Cross-targeting hypothesis could explain why.
One must have 2 infections to trigger the autoimmune reaction.
A virus on the inside and bacteria driven antibodies on the outside.

Infections that draw the immune system to the hypothalamus and cause cross-targeting there: staph, mycobacterias, pertussis.

eczema and staph
http://www.ncbi.nlm.nih.gov/pubmed/16965415

psoriasis and mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/26500993
http://www.ncbi.nlm.nih.gov/pubmed/26236445

mycobacteria infects the hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/25008390

psoriasis and multiple sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/26352056

If the mycobacteria involved in these diseases reaches the hypothalamus then the person is at risk for seizures

For Autoimmune cross-targeting to occur a virus must mark the inside.

For the nerves' myelin to be involved with multiple sclerosis that would be herpes zoster. For the neurons of the hypothalamus involved in seizures that would be enteroviruses.

zoster and multiple sclerosis (cross-targeting on myelin)
http://jid.oxfordjournals.org/content/204/2/177.full
http://www.medscape.com/viewarticle/744641
http://www.ncbi.nlm.nih.gov/pubmed/18306233

enteroviruses and seizures (cross-targeting at the hypothalamus)
http://www.ncbi.nlm.nih.gov/pubmed/11134476
http://www.bcmj.org/articles/acute-flaccid-paralysis-child-infected-enterovirus-d68-case-report
http://cid.oxfordjournals.org/content/32/2/236.full

The larger infection triggering the autoimmunity of the hypothalamus seems to consist of several possibilities.

Seizures and eczema (is this the staph reaching the hypothalamus?)
http://www.ncbi.nlm.nih.gov/pubmed/24251558

seizures and t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/26168861

seizures and spirochetes
http://www.ncbi.nlm.nih.gov/pubmed/23428457

pertussis and seizures
http://www.ncbi.nlm.nih.gov/pubmed/26529162



1 comment:

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