Tuesday, April 30, 2013

Behcet's Disease is it a cross-targeting autoimmune disease?

The autoimmune hypothesis pattern: an infection first inducing antibodies followed by a viral infection which causes cross-targeting thus triggering the immune system to attack causing autoimmune disease.

For Behcet's disease the infection culprits are Streptococcus sanguinis and herpes simplex (mouth ulcers)

http://www.ncbi.nlm.nih.gov/pubmed/23137016
http://www.ncbi.nlm.nih.gov/pubmed/18693149
http://www.ncbi.nlm.nih.gov/pubmed/21052488
http://www.ncbi.nlm.nih.gov/pubmed/22204815
http://www.ncbi.nlm.nih.gov/pubmed/22766172


I found a strange overlap with MS and Behcet's.
http://www.ncbi.nlm.nih.gov/pubmed/12645628

For MS I have as psoriasis or eczema with herpes zoster triggering the autoimmune disease.   

Could this be an entirely different type of MS? Where the strep has opened the blood brain barrier and the herpes virus is there?  Is this actually a form of Alzheimer's?   Where the herpes simplex virus is destroying the mitochondria?  Or do I need to become much more specific with the herpes viruses? That could be the case. 

Balo was/is a different type of MS where the virus is a hepatitis C virus and causing the ring shaped lesions. Balo is really a distinct autoimmune disease from MS. 

No comments:

Post a Comment