Is Churg Strauss disease an autoimmune vasculitis caused by cross-targeting?

Churg Strauss Autoimmune Vasculitis 

Autoimmune theory pattern: an infection first builds up antibodies followed by a viral infection/vaccine which causes cross-targeting thus triggering the autoimmune disease. 

Cross-targeting of the immune system triggers autoimmunity by layering immune system attacks onto one target.  One viral marking the inside of the target and one visible marking the outside of the target...like a fungus or bacteria.

 For Churg-Strauss it might be an Aspergillus infection followed by hepatitis B.

Aspergillus and Churg-strauss connections:
http://www.ncbi.nlm.nih.gov/pubmed/3195817
http://www.ncbi.nlm.nih.gov/pubmed/11141396
Acta clin Croat 2002; 41:95-98  
http://www.ncbi.nlm.nih.gov/pubmed/12456338

Eosinophili pneumonia and Aspergillus:
http://www.ncbi.nlm.nih.gov/pubmed/4209914

Chronic Eosinophilic pneumonia followed by Churg-strauss
http://www.ncbi.nlm.nih.gov/pubmed/8050532 
http://www.ncbi.nlm.nih.gov/pubmed/8938874
  
There seems to be quite an overlap between aspergillus and churg-strauss. I am suggesting that this infection exists first and builds up a state of antibodies.

Then the viral trigger appears in the system and causes cross-targeting.  Producing antibodies that aim at the same target as the earlier infection.

Hepatitis B existing infection and Churg strauss
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845776

Hepatitis B  vaccine and Churg Strauss
http://www.ncbi.nlm.nih.gov/pubmed/11791655
http://www.ncbi.nlm.nih.gov/pubmed/9709187

Both hepatitis B and aspergillus are bloodstream infections which is where the immune system cross targets in Churg Strauss.  Churg-strauss is an immune attack of the vascular system. 

  Churg strauss has also been associated with several years of asthma but only in some patients. This could be due to hot tub asthma or aspergillus in the lungs. (the state of heightened antibodies before the development of the autoimmune disease)
http://www.sepeap.org/archivos/pdf/10226.pdf

Aspergillus seems to like not just vascular and lung walls but intestinal walls. It has been found intestinal tracts too. http://medind.nic.in/ibv/t07/i5/ibvt07i5p375.pdf

Remember it is not aspergillus that causes Chaus-strauss or hepatitis B that causes Chaus-strauss rather the our own immune system after the cross-targeting of these infections to the same location.

The overlap of churg-strauss and polyneuropathy could be the fact that aspergillus makes aflatoxin and aflatoxin can damage the nerves
http://www.elsevier.es/en-revista-neurologia-495-articulo-peripheral-polyneuropathy-and-churgstrauss-syndrome-90304325
http://www.ncbi.nlm.nih.gov/pubmed/25695917
http://www.ncbi.nlm.nih.gov/pubmed/24797730
http://www.ncbi.nlm.nih.gov/pubmed/24626013
http://www.ncbi.nlm.nih.gov/pubmed/24170259

does aflatoxin cause nerve damage?

Foot drop and churg-strauss?
http://www.pcp.org.ph/files/PJIM%20Vol53%20No2/A_Case_Report_of_Churg-Strauss_Syndrome_Presenting_with_Foot_Drop.pdf
http://www.cssassociation.org/patient-stories-reader/items/im-not-drunk-its-churg-strauss-syndrome.html
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088945/

vitiligo and churg-strauss?


This is just a hypothesis and something to be further investigated.
Angela Biggs 

Added for interest:
titanium overcomes the UV light inhibition of the growth of aspergillus 
http://www.ncbi.nlm.nih.gov/pubmed/19579656

Note that aspergillus is a fungus that grows on bulbs and I am looking into allergies to bulb like plants in association to autoimmune vasculitis.  Allergies under consideration: onions, garlic, and  lilies. 

Is it Eales disease is when it involves the eye and overlaps with Hashimoto's and other autoimmune diseases?
https://www.ncbi.nlm.nih.gov/pubmed/20075970

Note that candida and cryptococcus which are also fungal infections I have linked to Hashimoto's thyroid disease on other posts.