Psoriasis as an autoimmune disease.
My autoimmune hypothesis is that a dimorphic infection builds up antibodies and then a virus pushes it into an autoimmune disease.
Psoriasis has the gluten sensitivity which makes me look for a dimorphic infection. what i found was not fungal or bacterial rather mycobacterias. Tuberculosis has been associated with psoriasis.
Mycobacteria cause macrophages to produce extremely high levels of il-6.
J. immunol 1997 jan 1; 158(1):330-7
www.jimmunol.org/content/158/1.toc
which is interesting because high levels of il-6 impairs insulin signalling and could cause insulin resistance.
Vitam Horm 2009; 80; 613-33
http://www.ncbi.nlm.nih.gov/pubmed/19251052
Psoriasis has a high incidence of type 2 diabetes with it not the autoimmune type 1 diabetes.
Psoriasis is associated with an increased risk of Parkinson's. Parkinson's in general has been associated with type 2 diabetes too.
http://www.dermatologyupdate.com.au/latest-news/psoriasis-and-parkinson-s-linked
Type 2 diabetes has been linked to asthma and obesity.
I don't see an "autoimmune cross-targeting attack" here but rather an inflammation that may be gluten sensitive which might indicate the culprit as mycobacterias.
Interestingly we know that EGCG in green tea inhibits the proliferation of mycobacterias...and the matcha form of green tea has the highest concentration. Could we halt the asthma and help the type 2 diabetes by simply drinking this strong green tea? Could it help gout and parkinsonisms?
Psoriasis has been shown to coexist with gout, psoriatic arthritis. Do these people tend to have asthma and type 2 diabetes?
Could gluten elimination help these associated diseases too? Obviously not all asthmas will be gluten sensitive (the eczema associated type would be milk and egg not wheat since it might be staph infection linked) Could a gluten free diet help those who were struggling with type 2 diabetes not just celiac disease? Even more hopeful...could elimination of the mycobacteria remove the diseases completely? Inflammation should not linger like antibodies do.
What do people think? Could it be that Psoriasis not an autoimmune disease but an inflammation driven one?
Still thinking,
Angela Biggs
Added thoughts: Gluten ataxia is the most common cause of sporadic idopathic ataxia.
Brain 2003 mar 126(pt3):685-91 Are the people who have the psoriasis that develop the parkinson's the same people that would have this form of gluten ataxia? since psoriasis is gluten sensitive?
Are all Parkinson's cases gluten sensitive because the group that appears to have vitiligo might be different.....right? Some Vitiligo has been associated with gluten so are these just different mycobacterias?
I am going to have to research how the types of parkinson's differ next.
In looking at Parkinson's I have found that they also have elevated il-6 thus strengthening the possible link to mycobacterias il-6 rise.
http://www.ncbi.nlm.nih.gov/pubmed/19857551
http://www.ncbi.nlm.nih.gov/pubmed/19214748
WOW...so here is a connection between il-6 and mitochondrial fragmentation or morphology.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746985/
Just for background for those who have not read all of my posts, under the alzheimer post I made this statement:
" Parkinson's has currently been viewed as a mitochondria disease in that PURL has been indicated. Purl is a rhomboid protease involved in the morphology of mitochondria. This would not stop the functioning of the mitochondria rather make transport of them down the axon more difficult. Purl might be breaking a large mitochondria suv into smaller mitochondria coopers....so to speak...thus a sporatic energy supply. I don't know if any one has looked into that but it makes me wonder. If Resveratrol is now said to induce mitochondria biogenesis and has been shown to extend the lifespan of yeast and flies....could it counter the problem in Parkinson's somewhat?"
Okay so i have made a small tangent from types of parkinson's to the mechanism of parkinson's but maybe there are overlaps with this purl and the il-6? both causing smaller mitochondrias?
I hope some one out there reads these posts and can make some connections.
Angela Biggs
Added April 14 2016: Autoimmune cross-targeting hypothesis is the simultaneous infections of 2 infections one on the inside and one on the outside: mycobacterias and HPV in the case of psoriasis
http://angelabiggs.blogspot.com/2016/01/psoriasis-hpv-mycoplasms-and-autoimmune.html
My autoimmune hypothesis is that a dimorphic infection builds up antibodies and then a virus pushes it into an autoimmune disease.
Psoriasis has the gluten sensitivity which makes me look for a dimorphic infection. what i found was not fungal or bacterial rather mycobacterias. Tuberculosis has been associated with psoriasis.
Mycobacteria cause macrophages to produce extremely high levels of il-6.
J. immunol 1997 jan 1; 158(1):330-7
www.jimmunol.org/content/158/1.toc
which is interesting because high levels of il-6 impairs insulin signalling and could cause insulin resistance.
Vitam Horm 2009; 80; 613-33
http://www.ncbi.nlm.nih.gov/pubmed/19251052
Psoriasis has a high incidence of type 2 diabetes with it not the autoimmune type 1 diabetes.
Psoriasis is associated with an increased risk of Parkinson's. Parkinson's in general has been associated with type 2 diabetes too.
http://www.dermatologyupdate.com.au/latest-news/psoriasis-and-parkinson-s-linked
Type 2 diabetes has been linked to asthma and obesity.
I don't see an "autoimmune cross-targeting attack" here but rather an inflammation that may be gluten sensitive which might indicate the culprit as mycobacterias.
Interestingly we know that EGCG in green tea inhibits the proliferation of mycobacterias...and the matcha form of green tea has the highest concentration. Could we halt the asthma and help the type 2 diabetes by simply drinking this strong green tea? Could it help gout and parkinsonisms?
Psoriasis has been shown to coexist with gout, psoriatic arthritis. Do these people tend to have asthma and type 2 diabetes?
Could gluten elimination help these associated diseases too? Obviously not all asthmas will be gluten sensitive (the eczema associated type would be milk and egg not wheat since it might be staph infection linked) Could a gluten free diet help those who were struggling with type 2 diabetes not just celiac disease? Even more hopeful...could elimination of the mycobacteria remove the diseases completely? Inflammation should not linger like antibodies do.
What do people think? Could it be that Psoriasis not an autoimmune disease but an inflammation driven one?
Still thinking,
Angela Biggs
Added thoughts: Gluten ataxia is the most common cause of sporadic idopathic ataxia.
Brain 2003 mar 126(pt3):685-91 Are the people who have the psoriasis that develop the parkinson's the same people that would have this form of gluten ataxia? since psoriasis is gluten sensitive?
Are all Parkinson's cases gluten sensitive because the group that appears to have vitiligo might be different.....right? Some Vitiligo has been associated with gluten so are these just different mycobacterias?
I am going to have to research how the types of parkinson's differ next.
In looking at Parkinson's I have found that they also have elevated il-6 thus strengthening the possible link to mycobacterias il-6 rise.
http://www.ncbi.nlm.nih.gov/pubmed/19857551
http://www.ncbi.nlm.nih.gov/pubmed/19214748
WOW...so here is a connection between il-6 and mitochondrial fragmentation or morphology.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746985/
Just for background for those who have not read all of my posts, under the alzheimer post I made this statement:
" Parkinson's has currently been viewed as a mitochondria disease in that PURL has been indicated. Purl is a rhomboid protease involved in the morphology of mitochondria. This would not stop the functioning of the mitochondria rather make transport of them down the axon more difficult. Purl might be breaking a large mitochondria suv into smaller mitochondria coopers....so to speak...thus a sporatic energy supply. I don't know if any one has looked into that but it makes me wonder. If Resveratrol is now said to induce mitochondria biogenesis and has been shown to extend the lifespan of yeast and flies....could it counter the problem in Parkinson's somewhat?"
Okay so i have made a small tangent from types of parkinson's to the mechanism of parkinson's but maybe there are overlaps with this purl and the il-6? both causing smaller mitochondrias?
I hope some one out there reads these posts and can make some connections.
Angela Biggs
Added April 14 2016: Autoimmune cross-targeting hypothesis is the simultaneous infections of 2 infections one on the inside and one on the outside: mycobacterias and HPV in the case of psoriasis
http://angelabiggs.blogspot.com/2016/01/psoriasis-hpv-mycoplasms-and-autoimmune.html
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