The autoimmune hypothesis : antibodies cross-target from 2 different infections and only then does autoimmune disease develop.
An infection, in this case mycobacterias, causes a build up of antibodies against dopamine nerves and then a virus infects the same target, these dopamine nerves, thus cross-targeting and giving another reason for the immune system to attack self causing the person to develop the autoimmune disease.
The genetic susceptibility of parkinson's overlaps leprosy.
http://news.sciencemag.org/sciencenow/2004/01/27-01.html
Parkinson's and Nocardia mycobacteria
http://drbroxmeyer.netfirms.com/parkinsons.pdf
For Parkinson's I have been looking at the overlap of il-6 and mycobacterias. The il-6 overlap occurs with type 2 diabetes, psoriasis, and parkinson's. Mycobacterias could be involved with all of these diseases.
While psoriasis and type 2 diabetes may be due to inflammation from infection and not an autoimmune disease because no viral trigger exists....Parkinson's disease appears to have a viral trigger. Thus parkinson's might be autoimmune because it fits the 2 stages.
NOTE: added 9/3 Psoriasis has now been linked to Parkinson's disease. Which makes sense if they are both mycobacteria diseases. http://www.dermatologyupdate.com.au/latest-news/psoriasis-and-parkinson-s-linked
Mycobacterias which are gluten sensitive create antibodies through dimorphic switching maybe priming the immune system. Dimorphic switching means that the infection changes morphology shape. (E.coli changes morphology when casein triggers the lon enzyme...and enzyme that also exist in mycobacterias)
http://www.ncbi.nlm.nih.gov/pubmed/9425059
As the mycobaterias change back and forth the immune system is generating antibody flags looking for them and one of these antibodies....should predictable be for the dopamine nerves. Unless even easier...the mycobacteria infect these nerves specifically.
The suspect already under consideration for Parkinson's is the bird flu.
The bird flu virus infects the dopamine nerves triggering the cross targeting. H5NI is the bird flu (all Influenza A are associated with aquatic birds but not all are referred to as the bird flu) The location of infection triggers the cross-targeting and the immune system develops into autoimmunity.
http://www.parkinson.org/NationalParkinsonFoundation/files/6d/6dea0022-01a5-4d55-926c-42efa0084c18.pdf
http://www.ncbi.nlm.nih.gov/pubmed/19667183
Now we just have to link, or find the antibodies, or at least be able to explain how antibodies from a mycobacteria would target the Dopamine nerves specifically. This is the closest i have so far and it is probably not the same mycobacteria we are dealing with.
Leprosy, antigens, and periphery nerves
http://www.ncbi.nlm.nih.gov/pubmed/6416726
Maybe Parkinson's is not just an inflammation issue but can be an autoimmune one? My autoimmune hypothesis pattern is an infection first followed by a viral cross-targeting. If mycobacterias start the situation is Parkinson's disease gluten sensitive? or just some of the parkinsonisms?
Here's an example of one parkinson's patient that after antibiotics recovered? Does this mean if you catch it early enough or are only some this type? Was he gluten sensitive ? Not celiac but still gluten sensitive.
http://www.newscientist.com/article/mg20927962.600-faecal-transplant-eases-symptoms-of-parkinsons.html
I have failed to find a scientific study or journal connecting the two but i did find this article indicating the worsening of Parkinson's with gluten related diseases.
http://www.livestrong.com/article/549400-gluten-sensitivity-parkinsons-disease/
I found that the rare Multiple system atropy kind is gluten sensitive but this is considered a parkinsonism.
http://www.ncbi.nlm.nih.gov/pubmed/?term=gluten+parkinson
Decent list of the types of parkinson's diseases:
http://www.parkinson.org/Parkinson-s-Disease/Diagnosis/What-are-the-different-types-of-atypical-Parkinson
The genetics of parkinson's infers autoimmune and infectious origin.
https://www.aarda.org/research_display.php?ID=89
I wish I had more information about the Parkinson's disease clusters and which group they are in. Anyone out there have this information? I did see a video clip where micheal j. fox was talking about taking the medication intended for the bird flu virus and getting relief. what does that mean? is the virus still active and continuously triggering the immune system?
Which brings me to the children in England which developed narcoplesy after getting a flu shot vaccine. Parkinson's overlaps sleep disorders. Are these kids symptoms related? Different because it was the swine flu H1N1 triggering the autoimmune reaction verse the bird flu H5N1?
Note that the H1N1 swine flu (H1N2 is also considered a swine flu) Has also been associated with nerve infection and inflammation by the virus. http://www.ncbi.nlm.nih.gov/pubmed/21744080
The flu has also been suspected in Parkinson's.
http://www.ncbi.nlm.nih.gov/pubmed/22361110
http://www.ncbi.nlm.nih.gov/pubmed/22753266
Flaviviruses and parkinson's (update april 2016) viruses like west nile
http://www.ncbi.nlm.nih.gov/pubmed/12935837
http://www.ncbi.nlm.nih.gov/pubmed/26719256
http://www.ncbi.nlm.nih.gov/pubmed/18760350
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/ (antiparkinson's drugs)
HLA-DR and parkinson's (cytosol mailbox for RNA virus) (this HLA part added 10/6/2016)
https://www.ncbi.nlm.nih.gov/pubmed/22807207 DRB1
https://www.ncbi.nlm.nih.gov/pubmed/25319953 DRA
I think where these viruses incubate in the body will be key to unraveling autoimmune diseases. Obviously some have more then one incubation area but because of the overlap with other tick disorders the focus seems to be the Basal Ganglia. (see the newer post on autoimmune diseases of the Basal Ganglia)
I would love to figure out which parkinson's diseases are autoimmune and might be connected to the mycobacterias and viruses. I have been assuming the most common type. Can anyone out there follow my logic?
Remember these are just ideas and unproven theories. I just hope they lead somewhere (please look at the psoriasis post too because it is connected to this one by mycobacterias)
Angela Biggs
An infection, in this case mycobacterias, causes a build up of antibodies against dopamine nerves and then a virus infects the same target, these dopamine nerves, thus cross-targeting and giving another reason for the immune system to attack self causing the person to develop the autoimmune disease.
The genetic susceptibility of parkinson's overlaps leprosy.
http://news.sciencemag.org/sciencenow/2004/01/27-01.html
Parkinson's and Nocardia mycobacteria
http://drbroxmeyer.netfirms.com/parkinsons.pdf
For Parkinson's I have been looking at the overlap of il-6 and mycobacterias. The il-6 overlap occurs with type 2 diabetes, psoriasis, and parkinson's. Mycobacterias could be involved with all of these diseases.
While psoriasis and type 2 diabetes may be due to inflammation from infection and not an autoimmune disease because no viral trigger exists....Parkinson's disease appears to have a viral trigger. Thus parkinson's might be autoimmune because it fits the 2 stages.
NOTE: added 9/3 Psoriasis has now been linked to Parkinson's disease. Which makes sense if they are both mycobacteria diseases. http://www.dermatologyupdate.com.au/latest-news/psoriasis-and-parkinson-s-linked
Mycobacterias which are gluten sensitive create antibodies through dimorphic switching maybe priming the immune system. Dimorphic switching means that the infection changes morphology shape. (E.coli changes morphology when casein triggers the lon enzyme...and enzyme that also exist in mycobacterias)
http://www.ncbi.nlm.nih.gov/pubmed/9425059
As the mycobaterias change back and forth the immune system is generating antibody flags looking for them and one of these antibodies....should predictable be for the dopamine nerves. Unless even easier...the mycobacteria infect these nerves specifically.
The suspect already under consideration for Parkinson's is the bird flu.
The bird flu virus infects the dopamine nerves triggering the cross targeting. H5NI is the bird flu (all Influenza A are associated with aquatic birds but not all are referred to as the bird flu) The location of infection triggers the cross-targeting and the immune system develops into autoimmunity.
http://www.parkinson.org/NationalParkinsonFoundation/files/6d/6dea0022-01a5-4d55-926c-42efa0084c18.pdf
http://www.ncbi.nlm.nih.gov/pubmed/19667183
Now we just have to link, or find the antibodies, or at least be able to explain how antibodies from a mycobacteria would target the Dopamine nerves specifically. This is the closest i have so far and it is probably not the same mycobacteria we are dealing with.
Leprosy, antigens, and periphery nerves
http://www.ncbi.nlm.nih.gov/pubmed/6416726
Maybe Parkinson's is not just an inflammation issue but can be an autoimmune one? My autoimmune hypothesis pattern is an infection first followed by a viral cross-targeting. If mycobacterias start the situation is Parkinson's disease gluten sensitive? or just some of the parkinsonisms?
Here's an example of one parkinson's patient that after antibiotics recovered? Does this mean if you catch it early enough or are only some this type? Was he gluten sensitive ? Not celiac but still gluten sensitive.
http://www.newscientist.com/article/mg20927962.600-faecal-transplant-eases-symptoms-of-parkinsons.html
I have failed to find a scientific study or journal connecting the two but i did find this article indicating the worsening of Parkinson's with gluten related diseases.
http://www.livestrong.com/article/549400-gluten-sensitivity-parkinsons-disease/
I found that the rare Multiple system atropy kind is gluten sensitive but this is considered a parkinsonism.
http://www.ncbi.nlm.nih.gov/pubmed/?term=gluten+parkinson
Decent list of the types of parkinson's diseases:
http://www.parkinson.org/Parkinson-s-Disease/Diagnosis/What-are-the-different-types-of-atypical-Parkinson
The genetics of parkinson's infers autoimmune and infectious origin.
https://www.aarda.org/research_display.php?ID=89
I wish I had more information about the Parkinson's disease clusters and which group they are in. Anyone out there have this information? I did see a video clip where micheal j. fox was talking about taking the medication intended for the bird flu virus and getting relief. what does that mean? is the virus still active and continuously triggering the immune system?
Which brings me to the children in England which developed narcoplesy after getting a flu shot vaccine. Parkinson's overlaps sleep disorders. Are these kids symptoms related? Different because it was the swine flu H1N1 triggering the autoimmune reaction verse the bird flu H5N1?
Note that the H1N1 swine flu (H1N2 is also considered a swine flu) Has also been associated with nerve infection and inflammation by the virus. http://www.ncbi.nlm.nih.gov/pubmed/21744080
The flu has also been suspected in Parkinson's.
http://www.ncbi.nlm.nih.gov/pubmed/22361110
http://www.ncbi.nlm.nih.gov/pubmed/22753266
Flaviviruses and parkinson's (update april 2016) viruses like west nile
http://www.ncbi.nlm.nih.gov/pubmed/12935837
http://www.ncbi.nlm.nih.gov/pubmed/26719256
http://www.ncbi.nlm.nih.gov/pubmed/18760350
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/ (antiparkinson's drugs)
HLA-DR and parkinson's (cytosol mailbox for RNA virus) (this HLA part added 10/6/2016)
https://www.ncbi.nlm.nih.gov/pubmed/22807207 DRB1
https://www.ncbi.nlm.nih.gov/pubmed/25319953 DRA
I think where these viruses incubate in the body will be key to unraveling autoimmune diseases. Obviously some have more then one incubation area but because of the overlap with other tick disorders the focus seems to be the Basal Ganglia. (see the newer post on autoimmune diseases of the Basal Ganglia)
I would love to figure out which parkinson's diseases are autoimmune and might be connected to the mycobacterias and viruses. I have been assuming the most common type. Can anyone out there follow my logic?
Remember these are just ideas and unproven theories. I just hope they lead somewhere (please look at the psoriasis post too because it is connected to this one by mycobacterias)
Angela Biggs
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