Saturday, April 6, 2013

Does the location of the bacteria decide which autoimmune disease develops in some cases? (autism, MS, and guillain barre)


So the hypothesis is: an infection builds up antibodies and then a virus triggers cross-targeting where the immune system then attacks. 

I am not sure what I am looking at tonight when I am looking at these nerve autoimmune diseases.

Autoimmune diseases with myelin protein antibodies:

schizophrenia correction...yes (https://www.ncbi.nlm.nih.gov/pubmed/2416737)
guillian barre syndrome yes
multiple sclerosis yes
autism yes

Autoimmune disease with measles or herpes?

schizophrenia yes
guillian barre syndrome yes
multiple sclerosis yes
autism yes for measles and herpes encephalitis (maybe zoster?)

Does measles or the herpes virus cause myelin protein antibodies?  I could not find a listing of the specific neural antibodies known to be generated by the measles vaccine.

If the same viruses are present for all 3 of these diseases does the bacteria infection make them different disease?

Guillain barre the suspect is Campylobacteria Jejuni. This infection begins in the gut but triggers the autoimmune paralysis of the legs...the peripheral nervous system.

references of Guillain barre and campylobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258
http://www.ncbi.nlm.nih.gov/pubmed/23514735
http://www.ncbi.nlm.nih.gov/pubmed/23528202

Multiple sclerosis my suspect is staph because of the association with eczema.  Staph is known to infect the central nervous system. Multiple sclerosis is a disease of the CNS.


In Autism the suspect is sutterella  which is known to be found in both the gut and brain abscesses. It seems possible that an infection that likes to live with our brain cells would try to look like a brain cell.  Autistic mother's who generate antibodies to the brain...do they have sutterella too like some of the autistic kids?
Sutterella and Autism ref
http://www.ncbi.nlm.nih.gov/pubmed/22233678

I wish we had more antibody data to look at.

Anyone out there think this is possible?
Hopeful,
Angela Biggs

Please note that the swine flu which can also infect the nerves has also been associated with guillain-barre. http://www.ncbi.nlm.nih.gov/pubmed/21744080

This is a cross-targeting issue of the immune not really an infection specific issue.

For Multiple sclerosis Herv-k which appears to be a central nervous system retrovirus could replace the measles or herpes as triggering the cross-targeting.   (added 5/28)








1 comment:

  1. The biggest problem with Fecal Transplant microbiotas is the fact that there is so little data available to back up the claims. A study in the Journal of Gastroenterology and Hepatology showed that FMT was effective at getting rid of C. difficile.

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