IgG4 antibodies

Autoimmune hypothesis: Two infections on one target triggers autoimmune disease. One infection inside and one infection outside of the cell.

Does the B cell that gets pulled from outside antigen pathways to inside antigen pathways become the IgG4 producing B cell with the goal of shutting down the outside pathways?

This would mean that the IgG4 would be similar based on the large infection and the pathway stopped if the autoimmune diseases share the same large infection.    For example, all mycobacteria triggered autoimmune diseases would have the same IgG4 against aquaporins.

IgG4 antibodies represent a down-regulatory response
https://www.ncbi.nlm.nih.gov/pubmed?term=24111912

IgG4 made by Bcells that produce il-10
https://www.jacionline.org/article/S0091-6749(13)00150-4/pdf

Br1 up regulate the plasma cells to become IgG4 producing
https://www.jacionline.org/article/S0091-6749(16)30722-9/pdf


Anti-Aquaporin

Mycobacteria and other bacterial cytosol infection which involve eosinophils and macrophages in a phagocytosis method appear to develop anti-AQP ( aquaporin antibodies)

aquaporins move eosoinophils
https://www.ncbi.nlm.nih.gov/pubmed/18510218

anti-aquaporin4 and multiple sclerosis
https://www.ncbi.nlm.nih.gov/pubmed/20705110

mycobacteria and multiple sclerosis
https://www.sciencedaily.com/releases/2010/02/100226084007.htm

idiopathic demyelination and anti-AQP4
https://www.hindawi.com/journals/msi/2017/1359761/

anti-aquaporin4 in neuromyelitis
https://www.ncbi.nlm.nih.gov/pubmed/18808744

salivary glands and parkinson's disease
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=838

salivary gland and psoriasis
https://www.ncbi.nlm.nih.gov/pubmed/7165375

salivary glands and aquaporins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783900/

parkinson's and mycobacteria
https://www.ncbi.nlm.nih.gov/pubmed/25459140

psoriasis and mycobacteria
https://www.ncbi.nlm.nih.gov/pubmed/9657322

aquaporin and psoriasis
https://www.ncbi.nlm.nih.gov/pubmed/21400035

(Candida also has portions move to the cytosol)

SJ and salivary
https://www.ncbi.nlm.nih.gov/pubmed/1055974

Candida and SJ
https://www.ncbi.nlm.nih.gov/pubmed/12973284

SJ and MS because of salivary
https://www.jwatch.org/jn200112200000006/2001/12/20/possible-association-between-sjogrens-syndrome


Anti-insulin

Type one diabetes : coxsackie/flu  and e.coli

Neutrophils kill e.coli. How are these connected to insulin?

neutrophils suppress insulin signalling ( enzyme secreted disrupts the receptor)
https://stke.sciencemag.org/content/5/243/ec250

Insulin seems to be required for the functioning of neutrophils.
https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.0104050

Does anti-growth hormone match up with celiac disease and anti-IGF-1 match up with alopecia? Is the IgG4 trying to stop the outer antigen pathway?

celiac and Growth hormone deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570481/

alopecia and IGF-1 deficiency
https://www.sciencedirect.com/science/article/pii/S1087002415305372

Does it always switch to il-10 and no IFN when B switches places or is it like this?

Anti-gangliosides

Involves vacuole bacteria

Guillian-barre and anti-gangliosides
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422685/

http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=5;spage=1324;epage=1331;aulast=Baskar

https://www.researchgate.net/publication/325884578_Anti-ganglioside_Antibodies_in_Peripheral_Nerve_Pathology

natural killer cells

il-15 and gangliosides
https://www.ncbi.nlm.nih.gov/pubmed/16116192

gangliosides in autism
https://www.ncbi.nlm.nih.gov/pubmed/9766735

sutterella and autism spectrum disorder
https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-4-42


Anti-ANCA / anti-ANA

involves golgi/ER bacterias

salmonella and anti-ANCA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905360/

reactive arthritis and salmonella
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195798/

anti-ANCA bind the neutrophil traps
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00439/full

Anti-ANCA and Rheumatoid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552688/

anti-nuclear in strep with tourettes
https://www.ncbi.nlm.nih.gov/pubmed/12699862

TLR8 and strep
http://www.jimmunol.org/content/195/3/1092

TLR8 is the Tcell mailbox for the Endoplasmic reticulum

polyarthritis and strep
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803937/


Anti-leiomodin

Nodding disease is triggered by the parasitic worm and what virus? The IgG4 was found against leiomodin-1.  Nodding disease is autoimmune disease of the skin where the autoantigen attacks the brain?

Autoimmune cross-targeting hypothesis: two infections on one tissue. The reaction is at the skin but then the antibody attacks the brain?

 For these worms how does this work? The Leiomodin-1 antibody bound the worms...but they were IgG4?

When exposed to cold temperatures or food the children nod their heads uncontrollably. The hippocampus of the brain is responsible for body temperature sensations and hunger urges.

The worm is not in the hippocampus but the autoantibody shows up there.
https://www.ncbi.nlm.nih.gov/pubmed/28202777

Which virus at the skin has co-infected and caused the IgG4?

Does this mean that leiomodin-1 is involved with eosinophils degranulation attack? Since eosinophils at the main cell type attacking the worms how would this work?

eosinophils and smooth muscles
https://www.ncbi.nlm.nih.gov/pubmed/23180361