How do myeloid and plasmacytoid dendritic cells get viral antigens from inside infected cells? From exosomes?
What about viruses that infect the nucleus or the mitochondria?
Cells infected with mitochondrial virus HCV secrete exosomes
When entering the lymph node the exosomes get absorbed by the SCS while larger antigens move down the conduit? how does that work?
Langerhans has the ability to pull through collagen fibers
https://www.ncbi.nlm.nih.gov/pubmed/1431200
Marginal zone B cells and pulling through collagen
https://www.cell.com/immunity/supplemental/S1074-7613(05)00339-0
The conduits in the lymph node/spleen are a network formed by collagen fibers
mDendritic and pDendritic squeeze between the scs cells using "dock8"
http://www.bloodjournal.org/content/119/19/4451?sso-checked=true
fantastic images
Are exosomes blocked from conduit travel?
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