The secondary lymph organs are strategically situated to intercept infections. The lymph glands capture the infections that breach the skin's barrier. The ILF and peyer patches guard the mucosal membranes. The blood brain barrier and the choroid plexus protects the brain. The spleen filters the blood removing not just dead blood cells but infections that have reached there. The omentum monitors and protects the peritoneal cavity which contains the stomach, the liver, the large and small intestines, the kidneys, the gall bladder, the pancreas, and the adrenal glands.
All secondary lymph organs have separate zones for fighting inner and outer antigens.
The inner antigens are processed by embryonic HSC derived macrophages. These macrophages communicate with and pass antigens to marginal reticular stromal cells or Astrocyte stromal cells. These cells with antigen evolve into follicular dendritic cells and secrete CXCL13 calling the B and the T cells to them. The dendritic cells are derived from adult HSC monocytes. These monocyte derived dendritic cells are the antigen presenting cells to the T cells. For inner antigens the T cell makes the determination at this point if the antigen is foreign.
The outer antigens are collected by langerhans, marginal zone B cells, B1, or Resident Tissue macrophages (of the CP) all of which differentiated from the yolk sac not the HSC of the bone marrow. These yolk sac derived cells communicate and pass antigens on to fibroblastic reticular stromal cells. These antigen holding FRC become follicular dendritic cells with B7-2 involvement and secrete CXCL13. These FDC cells hand the antigen off to B cells who do the antigen presenting to the T cell. For outer antigens the B cell determines if the antigen is foreign.
All secondary lymph organs have separate zones for fighting inner and outer antigens.
The inner antigens are processed by embryonic HSC derived macrophages. These macrophages communicate with and pass antigens to marginal reticular stromal cells or Astrocyte stromal cells. These cells with antigen evolve into follicular dendritic cells and secrete CXCL13 calling the B and the T cells to them. The dendritic cells are derived from adult HSC monocytes. These monocyte derived dendritic cells are the antigen presenting cells to the T cells. For inner antigens the T cell makes the determination at this point if the antigen is foreign.
The outer antigens are collected by langerhans, marginal zone B cells, B1, or Resident Tissue macrophages (of the CP) all of which differentiated from the yolk sac not the HSC of the bone marrow. These yolk sac derived cells communicate and pass antigens on to fibroblastic reticular stromal cells. These antigen holding FRC become follicular dendritic cells with B7-2 involvement and secrete CXCL13. These FDC cells hand the antigen off to B cells who do the antigen presenting to the T cell. For outer antigens the B cell determines if the antigen is foreign.
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