Chorioid Plexus compared to the BBB blood brain barrier

Chorioid Plexus compared to the BBB blood brain barrier and the hypothesis that they deal with different antigens.


Each of the brain's ventricles has their own CP region

Capillary blood is filtered here at the CP to become cerebrospinal fluid.

Resident macrophages and dendritic cells are in the CP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496674/

Note that resident macrophages come from the yolk and focus on outer antigens while travel monocytes come from bone marrow and develop into dendritic cells or macrophages that deal with inner antigens based on the hormone that they see. High insulin favors macrophages while IGF-1 or GH exposed monocytes develop into dendritic cells.

IGF-1 made by CP epithelial
https://www.ncbi.nlm.nih.gov/pubmed/7513042

this would favor dendritic over macrophages (traveling)

myeloid dendritic cells of the cp
https://www.ncbi.nlm.nih.gov/pubmed/16817190

CP : fibroblasts, macrophages, dendritic cells
https://www.frontiersin.org/articles/10.3389/fncel.2015.00136/full

astrocytes (stromal cells) attract dendritic cells
https://www.ncbi.nlm.nih.gov/pubmed/16106219

astrocytes activate B cells
https://www.ncbi.nlm.nih.gov/pubmed/29673365
https://www.ncbi.nlm.nih.gov/pubmed/26223505

pericytes and and astrocytes communication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042982/

FRC-like cells in CNS
https://www.cell.com/immunity/pdfExtended/S1074-7613(16)30001-2