Monday, October 24, 2016

Rheumatoid arthritis, HLA-DRB1, and retroviruses or a parvovirus or flu? ????

With the associations of plantar fasciitis, carpal tunnel, morning stiffness, and the visible inflammation of tendons I am leaning toward the tendons as the main autoimmune tissue target of rheumatoid arthritis.

Tendons were the first suspected target in 1969
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1031189/?page=1

Autoimmune cross-targeting hypothesis states that two infections on one target triggers autoimmune disease. An infection on the outside of the target and a viral infection on the inside.

Mycoplasmas have been linked to rheumatoid arthritis but which viruses trigger from the inside?

HLA-DRB1 and HLA-DR4
https://www.ncbi.nlm.nih.gov/pubmed/16126967

 HLA-DR4 and HLA-DR5
https://www.ncbi.nlm.nih.gov/pubmed/23537298

Using the HLA-location hypothesis one would match HLA-DR to cytosol viruses or bacteria

HLA-DR4 and the flu

HLA-DR5 and Retrovirus

hypothesis of retroviruses and RA
https://www.ncbi.nlm.nih.gov/pubmed/8060765

retroviruses induce arthritis in goats
http://www.microbiologyresearch.org/docserver/fulltext/jgv/65/9/JV0650091519.pdf?expires=1477339390&id=id&accname=guest&checksum=7D97A61DA035E095C025A3677BA36B61

High seroprevalence of HTLV in RA (oligoarthritis knee type?)
https://www.ncbi.nlm.nih.gov/pubmed/8607895
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-2-4
https://www.ncbi.nlm.nih.gov/pubmed/12787527
https://www.ncbi.nlm.nih.gov/pubmed/2053917

rheumatic heart disease
https://www.ncbi.nlm.nih.gov/pubmed/27521249

Another virus that triggers RA is the parvovirus

parvovirus and arthritis
https://www.ncbi.nlm.nih.gov/pubmed/15322815
https://www.ncbi.nlm.nih.gov/pubmed/18484700

Parvovirus, arthritis, and HLA-DRB1
https://jid.oxfordjournals.org/content/186/4/447.full

note that the parvovirus is a DNA virus

Raynaud's might be triggered by B19 erythrovirus (parvovirus in humans)
http://cid.oxfordjournals.org/content/30/3/500.full.pdf

 HLA-DR4 and HLA-DR5
https://www.ncbi.nlm.nih.gov/pubmed/23537298

HLA-DR4 has been connected to Totalis alopecia and the flu

swine flu vaccine has been suspected of trigger RA
https://www.hindawi.com/journals/crirh/2012/785028/
http://rheumatology.oxfordjournals.org/content/42/7/907.full
http://patient.info/forums/discuss/reaction-to-flu-and-swine-flu-jab-33993

HLA-DR4 has also been connected with type one diabetes. The flu has been known to trigger type one diabetes.

Note that these same viruses my cross-target with spirochetes instead of mycoplasmas to cause "lyme arthritis"
https://www.ncbi.nlm.nih.gov/pubmed/2078208




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