Autoimmune cross-targeting hypothesis: the layering of 2 different infections on one target cell type triggers autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.
Schizophrenia and autoimmune cross-targeting of the amygdala. Different infections on the amygdala will trigger schizophrenia as long as one infects the inside and one infects the outside.
we know the amydala is involved in schizophrenia and it's hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24619536
http://www.ncbi.nlm.nih.gov/pubmed/20071145
Schizophrenia and t.gondii has long been suspected
http://wwwnc.cdc.gov/eid/article/9/11/03-0143_article
http://www.medicalnewstoday.com/articles/284681.php
Other infections at the amygdala could cause it...but t.gondii has the most evidence so far.
(at the bottom of the page I will look at mycobacterias as another culprit. )
(Also note that the T.gondii group I suspect may have bee allergies where as the mycobacteria group are more likely to have shellfish allergies)
So what virus is infecting the inside? Several have been looked at:
herpes and t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/21991754
mother's antibodies to HSV-2 and a child with schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/15319094
resent onset schizophrenia antibodies: CMV and HHV6
https://www.ncbi.nlm.nih.gov/pubmed/14991372
Earlier post about hearing loss, schizophrenia, and newborns
http://angelabiggs.blogspot.com/2014/12/tgondii-and-cytomegalovirus-both.html
So which herpes virus causes Schizophrenia by cross-targeting with t.gondii?
All 3 receptors are there at the amygdala and I believe they each cause a different type of schizophrenia based on the receptor they use....thus the 3 major types of schizophrenia.
(these receptor virus match ups are another hypothesis that is not proven but they help describe what we are seeing and since LYSINE has been shown to slow replication of all herpes viruses this simple amino acid could help....IF....these hypotheses are correct)
Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2, herpes zoster : Estrogen-beta receptors (nerves and uterine tissue )
Beta-herpes viruses: CMV, HHV6, HHV7 : Estrogen-related receptors (CMV binding confirmed)
Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)
the amygdala has estrogen alpha receptors and beta receptors
http://languagelog.ldc.upenn.edu/myl/ldc/llog/Brizendine/Jasnow2006.pdf
and estrogen-related receptor-gammas.
Can we divide these into different types of schizophrenia: disorganized, catatonic, paranoid?
DISORGANIZED : HLA-A2 and HLA-A11 : beta-herpes (CMV)
The estrogen related receptors have been connected to spatial learning.
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-47134/
http://www.omim.org/entry/602969
Some schizophrenia has spatial learning issues
http://www.sciencedirect.com/science/article/pii/S2213158212000253
http://www.ncbi.nlm.nih.gov/pubmed/16048451
Could this be the "disorganized schizophrenia" group be similar to spatial issues and linked to the Estrogen Related Receptors and CMV?
CMV and estrogen related receptors link
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/
CMV, hearing loss, schizophrenia, and t.gondii in young children
http://angelabiggs.blogspot.com/2014/12/tgondii-and-cytomegalovirus-both.html
CMV and HLA-A11
http://www.bloodjournal.org/content/98/2/500?sso-checked=true
CATATONIC : HLA-B16 : Alpha-herpes (zoster, simplex)
Could the catatonic group be linked to the estrogen-beta receptor?
catatonic and herpes simplex 1 which uses beta
http://www.ncbi.nlm.nih.gov/pubmed/21364369
http://www.ncbi.nlm.nih.gov/pubmed/6487432
http://www.ncbi.nlm.nih.gov/pubmed/6722708
http://www.ncbi.nlm.nih.gov/pubmed/4370982
"spice" has been shown to trigger catatonic schizophrenia
http://www.schizophrenic.com/news/schizophrenia-research/studies-link-spice-drug-catatonic-psychosis
http://guilfordjournals.com/doi/abs/10.1521/psyc.2014.77.2.206
studies of this drug cold help elucidate if the beta receptor is used in catatonic schizophrenia
The beta-estrogen receptor cycles to the mitochondria of cells. The mitochondria is the "ATP power generator" for the cell allowing for movement. Catatonic is by definition the lack of movement. How does this all fit together?
HLA-B16 and schizo
https://www.researchgate.net/publication/14045457_HLA_antigens_in_schizophrenia_and_mood_disorders
PARANOID: HLA-A9 and HLA-A3 : Gamma Herpes (EBV)
Does paranoid schizophrenia use the alpha-estrogen receptor?
When just paranoid schizophrenia was looked at only EBV antibodies were found. Which would imply the alpha receptor.
http://www.sciencedirect.com/science/article/pii/S0920996411001605
Looking at the estrogen receptor genes they found that alpha receptor and beta receptor differences in schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/22001950
For paranoid schizophrenia an alpha estrogen gene mutation has been linked!
https://www.ncbi.nlm.nih.gov/pubmed/23497414
HLA-A9 and HLA-Cw4 (HLA-A is the nuclear mailbox) with paranoid schizo
https://www.cambridge.org/core/journals/psychological-medicine/article/is-schizophrenia-an-hla-associated-disease/2D67B606AE25A4C05A087DA7F9E31887
estrogen appears to be protective for woman against schizophrenia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860106/
alpha-receptors are strongly correlated with social behaviors
http://www.ncbi.nlm.nih.gov/pubmed/12488114
http://www.ncbi.nlm.nih.gov/pubmed/9213137
schizophrenia and social behaviors
http://www.ncbi.nlm.nih.gov/pubmed/20417974
We have known that during hormonal fluxes estrogen psychosis can result
http://psychcentral.com/news/2010/01/21/estrogen-may-prevent-psychosis/10886.html
Mycobacterias might replace T.gondii as the large outer infection
Previously on this blog I connected Mycobacterias to type 2 diabetes and high cholesterol through the use of it's quorum cGMP
http://angelabiggs.blogspot.com/2015/12/mycobacterias-possible-connection-to.html
Schizophrenia and metabolic disorder
http://www.ncbi.nlm.nih.gov/pubmed/17685741
Schizophrenia and type 2 diabetes
http://www.mdedge.com/currentpsychiatry/article/64865/schizophrenia-other-psychotic-disorders/link-between-schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16280338
http://www.ncbi.nlm.nih.gov/pubmed/15538314
Schizophrenia and high cholesterol
http://www.sciencedirect.com/science/article/pii/S0165032705002995
psoriasis and schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/21985649
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928455/ (and mood disorders)
file:///Users/angelabiggs/Downloads/fulltext-schizophrenia-v2-id1006%20(2).pdf
note that those with both schizophrenia and bipolar are at the highest risk for metabolic syndrome
http://www.healthyplace.com/diabetes/mental-health/metabolic-syndrome/
Bipolar is cross-targeting of the Anterior cingulate
Bipolar 1 : T.gondii and CMV
(more common in children?)
Bipolar 2: mycobacteria and CMV
(overlaps with high cholesterol and type 2 diabetes)
Hyperthyroid caused Bipolar-like...connected to graves and RA?
Hoarding and depression: spirochetes secreting high cortisone...not autoimmune either no cycles
HLA-A2 group (the nuclear mailbox)
https://www.researchgate.net/publication/14045457_HLA_antigens_in_schizophrenia_and_mood_disorders
Alzheimer's and schizophrenia should exist only in the catatonic type
Alzheimer's I had hypothesized caused by damaged mitochondrias.
In the case of Schizophrenia only one herpes virus type damages the mitochondria the Alpha herpes family including herpes zoster, HSV1, and HSV2 which uses the beta estrogen receptors. Beta-estrogen receptors cycle to the nerves mitochondria.
Alzheimer's and schizophrenia ....catatonic?
http://onlinelibrary.wiley.com/doi/10.1111/j.1479-8301.2007.00218.x/abstract
https://www.ncbi.nlm.nih.gov/pubmed/8732586
https://www.ncbi.nlm.nih.gov/pubmed/19748376
https://www.ncbi.nlm.nih.gov/pubmed/12788685
http://www.techtimes.com/articles/20929/20141125/the-surprising-link-between-alzheimers-and-schizophrenia.htm
HLA-B16 group (mitochondrial mailbox)
Parkinson's, Lewy bodies, bipolar, and schizophrenia
This overlap can only be caused by the shared mycobacterias
Lewy bodies are caused by mycobacteria's quorum, cGMP, in the brain
Parkinson's is the autoimmune cross-targeting of mycobacteria with a virus (flavivirus or flu) at the substantia nigra.
Bipolar 2 is mycobateria and cmv at the anterior singulate.
Schizophrenia is the mycobacteria with a herpes virus at the amygdala.
Thus if you are unlucky and catch a mycobacteria you are vulnerable to these autoimmune reactions if it gets into your brain. (and then you catch viral infections hence these autoimmune diseases can appear in different orders)
HLA-B27 I had linked to mitochondrial issues from bacterial proteins
HLA-B27 appears with schizophrenia...is this from the mycobacterias or t.gondii?
https://www.researchgate.net/publication/16252641_HLA_antigens_and_schizophrenia_A_pool_of_two_studies
Schizophrenia and autoimmune cross-targeting of the amygdala. Different infections on the amygdala will trigger schizophrenia as long as one infects the inside and one infects the outside.
we know the amydala is involved in schizophrenia and it's hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24619536
http://www.ncbi.nlm.nih.gov/pubmed/20071145
Schizophrenia and t.gondii has long been suspected
http://wwwnc.cdc.gov/eid/article/9/11/03-0143_article
http://www.medicalnewstoday.com/articles/284681.php
Other infections at the amygdala could cause it...but t.gondii has the most evidence so far.
(at the bottom of the page I will look at mycobacterias as another culprit. )
(Also note that the T.gondii group I suspect may have bee allergies where as the mycobacteria group are more likely to have shellfish allergies)
So what virus is infecting the inside? Several have been looked at:
herpes and t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/21991754
mother's antibodies to HSV-2 and a child with schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/15319094
resent onset schizophrenia antibodies: CMV and HHV6
https://www.ncbi.nlm.nih.gov/pubmed/14991372
Earlier post about hearing loss, schizophrenia, and newborns
http://angelabiggs.blogspot.com/2014/12/tgondii-and-cytomegalovirus-both.html
So which herpes virus causes Schizophrenia by cross-targeting with t.gondii?
All 3 receptors are there at the amygdala and I believe they each cause a different type of schizophrenia based on the receptor they use....thus the 3 major types of schizophrenia.
(these receptor virus match ups are another hypothesis that is not proven but they help describe what we are seeing and since LYSINE has been shown to slow replication of all herpes viruses this simple amino acid could help....IF....these hypotheses are correct)
Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2, herpes zoster : Estrogen-beta receptors (nerves and uterine tissue )
Beta-herpes viruses: CMV, HHV6, HHV7 : Estrogen-related receptors (CMV binding confirmed)
Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)
http://languagelog.ldc.upenn.edu/myl/ldc/llog/Brizendine/Jasnow2006.pdf
and estrogen-related receptor-gammas.
Can we divide these into different types of schizophrenia: disorganized, catatonic, paranoid?
DISORGANIZED : HLA-A2 and HLA-A11 : beta-herpes (CMV)
The estrogen related receptors have been connected to spatial learning.
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-47134/
http://www.omim.org/entry/602969
Some schizophrenia has spatial learning issues
http://www.sciencedirect.com/science/article/pii/S2213158212000253
http://www.ncbi.nlm.nih.gov/pubmed/16048451
Could this be the "disorganized schizophrenia" group be similar to spatial issues and linked to the Estrogen Related Receptors and CMV?
CMV and estrogen related receptors link
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/
CMV, hearing loss, schizophrenia, and t.gondii in young children
http://angelabiggs.blogspot.com/2014/12/tgondii-and-cytomegalovirus-both.html
CMV and HLA-A11
http://www.bloodjournal.org/content/98/2/500?sso-checked=true
CATATONIC : HLA-B16 : Alpha-herpes (zoster, simplex)
Could the catatonic group be linked to the estrogen-beta receptor?
catatonic and herpes simplex 1 which uses beta
http://www.ncbi.nlm.nih.gov/pubmed/21364369
http://www.ncbi.nlm.nih.gov/pubmed/6487432
http://www.ncbi.nlm.nih.gov/pubmed/6722708
http://www.ncbi.nlm.nih.gov/pubmed/4370982
"spice" has been shown to trigger catatonic schizophrenia
http://www.schizophrenic.com/news/schizophrenia-research/studies-link-spice-drug-catatonic-psychosis
http://guilfordjournals.com/doi/abs/10.1521/psyc.2014.77.2.206
studies of this drug cold help elucidate if the beta receptor is used in catatonic schizophrenia
The beta-estrogen receptor cycles to the mitochondria of cells. The mitochondria is the "ATP power generator" for the cell allowing for movement. Catatonic is by definition the lack of movement. How does this all fit together?
HLA-B16 and schizo
https://www.researchgate.net/publication/14045457_HLA_antigens_in_schizophrenia_and_mood_disorders
PARANOID: HLA-A9 and HLA-A3 : Gamma Herpes (EBV)
Does paranoid schizophrenia use the alpha-estrogen receptor?
When just paranoid schizophrenia was looked at only EBV antibodies were found. Which would imply the alpha receptor.
http://www.sciencedirect.com/science/article/pii/S0920996411001605
Looking at the estrogen receptor genes they found that alpha receptor and beta receptor differences in schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/22001950
For paranoid schizophrenia an alpha estrogen gene mutation has been linked!
https://www.ncbi.nlm.nih.gov/pubmed/23497414
HLA-A9 and HLA-Cw4 (HLA-A is the nuclear mailbox) with paranoid schizo
https://www.cambridge.org/core/journals/psychological-medicine/article/is-schizophrenia-an-hla-associated-disease/2D67B606AE25A4C05A087DA7F9E31887
estrogen appears to be protective for woman against schizophrenia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860106/
alpha-receptors are strongly correlated with social behaviors
http://www.ncbi.nlm.nih.gov/pubmed/12488114
http://www.ncbi.nlm.nih.gov/pubmed/9213137
schizophrenia and social behaviors
http://www.ncbi.nlm.nih.gov/pubmed/20417974
We have known that during hormonal fluxes estrogen psychosis can result
http://psychcentral.com/news/2010/01/21/estrogen-may-prevent-psychosis/10886.html
Mycobacterias might replace T.gondii as the large outer infection
Previously on this blog I connected Mycobacterias to type 2 diabetes and high cholesterol through the use of it's quorum cGMP
http://angelabiggs.blogspot.com/2015/12/mycobacterias-possible-connection-to.html
Schizophrenia and metabolic disorder
http://www.ncbi.nlm.nih.gov/pubmed/17685741
Schizophrenia and type 2 diabetes
http://www.mdedge.com/currentpsychiatry/article/64865/schizophrenia-other-psychotic-disorders/link-between-schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16280338
http://www.ncbi.nlm.nih.gov/pubmed/15538314
Schizophrenia and high cholesterol
http://www.sciencedirect.com/science/article/pii/S0165032705002995
psoriasis and schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/21985649
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928455/ (and mood disorders)
file:///Users/angelabiggs/Downloads/fulltext-schizophrenia-v2-id1006%20(2).pdf
note that those with both schizophrenia and bipolar are at the highest risk for metabolic syndrome
http://www.healthyplace.com/diabetes/mental-health/metabolic-syndrome/
Bipolar is cross-targeting of the Anterior cingulate
Bipolar 1 : T.gondii and CMV
(more common in children?)
Bipolar 2: mycobacteria and CMV
(overlaps with high cholesterol and type 2 diabetes)
Hyperthyroid caused Bipolar-like...connected to graves and RA?
Hoarding and depression: spirochetes secreting high cortisone...not autoimmune either no cycles
HLA-A2 group (the nuclear mailbox)
https://www.researchgate.net/publication/14045457_HLA_antigens_in_schizophrenia_and_mood_disorders
Alzheimer's and schizophrenia should exist only in the catatonic type
Alzheimer's I had hypothesized caused by damaged mitochondrias.
In the case of Schizophrenia only one herpes virus type damages the mitochondria the Alpha herpes family including herpes zoster, HSV1, and HSV2 which uses the beta estrogen receptors. Beta-estrogen receptors cycle to the nerves mitochondria.
Alzheimer's and schizophrenia ....catatonic?
http://onlinelibrary.wiley.com/doi/10.1111/j.1479-8301.2007.00218.x/abstract
https://www.ncbi.nlm.nih.gov/pubmed/8732586
https://www.ncbi.nlm.nih.gov/pubmed/19748376
https://www.ncbi.nlm.nih.gov/pubmed/12788685
http://www.techtimes.com/articles/20929/20141125/the-surprising-link-between-alzheimers-and-schizophrenia.htm
HLA-B16 group (mitochondrial mailbox)
Parkinson's, Lewy bodies, bipolar, and schizophrenia
This overlap can only be caused by the shared mycobacterias
Lewy bodies are caused by mycobacteria's quorum, cGMP, in the brain
Parkinson's is the autoimmune cross-targeting of mycobacteria with a virus (flavivirus or flu) at the substantia nigra.
Bipolar 2 is mycobateria and cmv at the anterior singulate.
Schizophrenia is the mycobacteria with a herpes virus at the amygdala.
Thus if you are unlucky and catch a mycobacteria you are vulnerable to these autoimmune reactions if it gets into your brain. (and then you catch viral infections hence these autoimmune diseases can appear in different orders)
HLA-B27 I had linked to mitochondrial issues from bacterial proteins
HLA-B27 appears with schizophrenia...is this from the mycobacterias or t.gondii?
https://www.researchgate.net/publication/16252641_HLA_antigens_and_schizophrenia_A_pool_of_two_studies
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