Monday, September 26, 2016

Myelodysplastic syndromes and idopathic thrombocytopenia have an overlap because they share viral infections

Myelodysplastic syndromes and idopathic thrombocytopenia have an overlap because they share viral infections: the EBV virus and flaviviruses.

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.
Autoimmune cross-targeting has a virus marking the inside of cells for immune attack.

Older post:
Benzene, leukemia, and these same viruses: EBV or flaviruses
http://angelabiggs.blogspot.com/2016/04/leukemia-and-co-carcinogenesis.html

Note that benzene alone, with no the virus there, would inhibit polymerases causing stunted cell division thus anemia.

benzene inhibits polymerases
http://www.ncbi.nlm.nih.gov/pubmed/3381009
http://www.ncbi.nlm.nih.gov/pubmed/2926830

Myelodysplastic syndromes

EBV and myeloma
http://www.ncbi.nlm.nih.gov/pubmed/22234097

Hepatitis C and myeloma (hepatitis C is a flavivirus)
http://www.ncbi.nlm.nih.gov/pubmed/16610042
http://news.cancerconnect.com/hepatitis-c-infection-increases-risk-of-lymphoma-and-multiple-myeloma/

HLA-dr15 connected to Flaviviruses (Added dec 2016)

HLA-dr2/ HLA-dr15 and myelodysplastic syndrome (added dec 2016)
http://www.bloodjournal.org/content/100/5/1570?sso-checked=true


Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, spirochete infection marking the outside.

Idopathic thrombocytopenia is a spirochete and a flavivirus or a flu virus or EBV

H.pylori (spirochete) and  thrombocytopenia
http://www.ncbi.nlm.nih.gov/pubmed/24574745
http://www.ncbi.nlm.nih.gov/pubmed/25728540
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177465/
http://www.ncbi.nlm.nih.gov/pubmed/27603101
http://www.ncbi.nlm.nih.gov/pubmed/27326941

Lyme (spirochete) and thrombocytopenia
http://cid.oxfordjournals.org/content/22/6/1119.full.pdf
http://ispub.com/IJID/2/2/3023
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882572/
http://www.ncbi.nlm.nih.gov/pubmed/8183774

previous post of thrombocytopenia
http://angelabiggs.blogspot.com/2014/09/is-idopathic-thrombocytopenic-purpura.html

EBV and thrombocytopenia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026329/





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