Saturday, April 9, 2016

Benzene, bone marrow, and co-carcinogenesis: a carcinogen and a virus synergistically causing cancer (Zika's flavivirus family is involved)

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.

My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body. Benzene saturates and waits in the bone marrow.

With all the fracking contaminating well water with benezene...the public should be aware of the risks.

benzene and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/9118924
http://www.ncbi.nlm.nih.gov/pubmed/27049659
http://www.ncbi.nlm.nih.gov/pubmed/9155776
http://www.ncbi.nlm.nih.gov/pubmed/9118924

childhood leukemia and benzene
http://www.medscape.com/viewarticle/857205
http://www.ncbi.nlm.nih.gov/pubmed/27043530
http://www.ncbi.nlm.nih.gov/pubmed/26589707
http://www.ncbi.nlm.nih.gov/pubmed/25333868

anemia and benzene (alone it inhibits growth)
http://www.ncbi.nlm.nih.gov/pubmed/8987251
how benzene causes this is unknown

benzene inhibits polymerases
http://www.ncbi.nlm.nih.gov/pubmed/3381009
http://www.ncbi.nlm.nih.gov/pubmed/2926830
http://www.ncbi.nlm.nih.gov/pubmed/4006011 (mito but still a polymerase....needs to happen in the nucleus to cause cancer)

Leukemia and benzene from highway
http://timesofindia.indiatimes.com/life-style/health-fitness/health-news/Living-near-highway-may-increase-leukemia-risk-in-kids/articleshow/49009660.cms

Soda/drinks with too much benzene: is this still an issue?
http://www.cbsnews.com/news/fda-too-much-benzene-in-some-drinks/

FDA and benzene testing in sodas (vit C involved.. stick to OJ or other natural sources)
http://www.fda.gov/Food/FoodborneIllnessContaminants/ChemicalContaminants/ucm055131.htm

Fracking water and benzene...a thousand times what the FDA considers safe
http://www.latimes.com/local/california/la-me-fracking-20150211-story.html

link to other carcinogens and polymerases


The viruses that infect bone marrow where the benzene is known to go:

Flaviviruses seem linked to leukemia

Flaviviruses and bone marrow
http://www.ncbi.nlm.nih.gov/pubmed/7663049
Hepatitis C (flavivirus)
http://www.ncbi.nlm.nih.gov/pubmed/20095034
http://www.ncbi.nlm.nih.gov/pubmed/8037177
Dengue and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/24793316
west nile and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/16344671
http://journals.lww.com/jpho-online/Abstract/2005/12000/West_Nile_Virus_Infection_in_a_Teenage_Boy_With.6.aspx
http://wwwnc.cdc.gov/eid/article/7/4/01-7432_article ?
http://www.auntminnie.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=56900?

Zika fatalities :

"The patients who died were a 2-year-old girl, a 30-year-old woman, a 61-year-old man, and a 72-year-old woman. The two older patients had underlying medical conditions that were well-controlled with medications. After death, the two younger ones were found to likely have had acute leukemia."
http://www.cidrap.umn.edu/news-perspective/2016/04/report-outlines-patterns-rare-fatal-zika-infections

Would the viral encephalitis of Zika patients would look like other flaviviral infections. (brain image D)? or because the virus uses ACTH receptors is it wide spread???


Herpes viruses seem to be linked to Hodgkin lymphoma

Epstein barr and lymphoma
http://www.sciencedirect.com/science/article/pii/S0093775414003017
http://www.ncbi.nlm.nih.gov/pubmed/25400806
http://www.ncbi.nlm.nih.gov/pubmed/24228130

CMV and bone marrow
http://www.ncbi.nlm.nih.gov/pubmed/9052914

there are community clusters of leukemia and lymphoma suggesting a similar cause (like benzene)
http://aje.oxfordjournals.org/content/162/9/817.long 

The leukemia clusters:
http://www.ncbi.nlm.nih.gov/pubmed/21352818


note that non-hodgkin's typically starts at the lymph nodes not at the bone marrow and still could be caused by epstein barr infecting with the estrogen receptors but the carcinogen is different.

mothballs and non-hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247554/

Is naphthalene the carcinogen that goes the lymph glands?







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