Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/
My co-carcinogenesis takes his further because carcinogens inhibit polymerases.
What I surmise from his hypothesis:
Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell's nucleus as a carcinogen they interact. Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen.
Non-Hodgkin's Lymphoma carcinogens
Naphthalene
http://epub.uni-regensburg.de/29760/1/journal.pone.0092787.pdf
http://onlinelibrary.wiley.com/store/10.1002/3527600418.mb9120e0011/asset/mb9120e0011.pdf?v=1&t=imv0o9nh&s=36f6894effd0fb56bec5bd1ccdb4d9f1329d3d1c
black tattoo and lymph nodes: Carbon Black or polycyclic aromatic hydrocarbons (PAH).
http://epub.uni-regensburg.de/29760/1/journal.pone.0092787.pdf
Napthalene is a PAH (joined benzene rings)
http://www.env.gov.bc.ca/wat/wq/BCguidelines/pahs/pahs-01.htm
mothballs and non-hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247554/
Parasites that feed on red blood cells like malaria release free heme into the blood which the parasites convert to Hemozion (brown malaria pigment) Could this process possibly produce a carcinogen ? Explaining the patterns in Africa? Does the parasite's enzyme that binds heme also bind polymerases? The known carcinogen benzene binds both heme and polymerases...just a thought.
Diffuse large B cell lymphomas (most common)
Hepatitis C and EBV...still researching this one
EBV and diffuse (slow type?)
https://www.ncbi.nlm.nih.gov/pubmed/26258272
https://www.ncbi.nlm.nih.gov/pubmed/25475080
Hep C and Diffuse (fast?)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145748/
Follicular lymphoma and polyomaviruses
merkel cell polyomavirus and follicular lymphoma
https://www.ncbi.nlm.nih.gov/pubmed/21414663
simian virus 40 and non-hodgkin's
http://www.ncbi.nlm.nih.gov/pubmed/25877010
http://www.ncbi.nlm.nih.gov/pubmed/15367569
http://www.ncbi.nlm.nih.gov/pubmed/15941954
JC and BK polyomaviruses
http://www.ncbi.nlm.nih.gov/pubmed/16537714
http://www.ncbi.nlm.nih.gov/pubmed/15941954
Hepatitis B
http://www.ncbi.nlm.nih.gov/pubmed/26885191
http://www.ncbi.nlm.nih.gov/pubmed/23562041
note that non-hodgkin's typically starts at the lymph nodes not at the bone marrow and still could be caused by epstein barr infecting with the estrogen receptors
http://www.ncbi.nlm.nih.gov/pubmed/22247563
Burkitt Lymphoma
Two types of Burkitt : endemic (africa & brazil) and sporatic (western countries with AIDS)
https://www.researchgate.net/publication/307157262_Differential_IgM_expression_distinguishes_two_types_of_pediatric_Burkitt_lymphoma_in_mouse_and_human
Does only EBV cause Burkitt or can HIV cause it too?
HIV and herv-k
http://journals.lww.com/jaids/Fulltext/2011/04002/183_HIV_Exposes_Major__Trafficking__in_HERV__K.76.aspx
Note that EBV was first isolated in 1964 from a Burkitt tumor of an african patient
Burkitt lymphoma and epstein barr
My co-carcinogenesis takes his further because carcinogens inhibit polymerases.
Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell's nucleus as a carcinogen they interact. Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen.
Non-Hodgkin's Lymphoma carcinogens
Naphthalene
http://epub.uni-regensburg.de/29760/1/journal.pone.0092787.pdf
http://onlinelibrary.wiley.com/store/10.1002/3527600418.mb9120e0011/asset/mb9120e0011.pdf?v=1&t=imv0o9nh&s=36f6894effd0fb56bec5bd1ccdb4d9f1329d3d1c
black tattoo and lymph nodes: Carbon Black or polycyclic aromatic hydrocarbons (PAH).
http://epub.uni-regensburg.de/29760/1/journal.pone.0092787.pdf
Napthalene is a PAH (joined benzene rings)
http://www.env.gov.bc.ca/wat/wq/BCguidelines/pahs/pahs-01.htm
mothballs and non-hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247554/
Parasites that feed on red blood cells like malaria release free heme into the blood which the parasites convert to Hemozion (brown malaria pigment) Could this process possibly produce a carcinogen ? Explaining the patterns in Africa? Does the parasite's enzyme that binds heme also bind polymerases? The known carcinogen benzene binds both heme and polymerases...just a thought.
Diffuse large B cell lymphomas (most common)
Hepatitis C and EBV...still researching this one
EBV and diffuse (slow type?)
https://www.ncbi.nlm.nih.gov/pubmed/26258272
https://www.ncbi.nlm.nih.gov/pubmed/25475080
Hep C and Diffuse (fast?)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145748/
Follicular lymphoma and polyomaviruses
merkel cell polyomavirus and follicular lymphoma
https://www.ncbi.nlm.nih.gov/pubmed/21414663
simian virus 40 and non-hodgkin's
http://www.ncbi.nlm.nih.gov/pubmed/25877010
http://www.ncbi.nlm.nih.gov/pubmed/15367569
http://www.ncbi.nlm.nih.gov/pubmed/15941954
JC and BK polyomaviruses
http://www.ncbi.nlm.nih.gov/pubmed/16537714
http://www.ncbi.nlm.nih.gov/pubmed/15941954
Hepatitis B
http://www.ncbi.nlm.nih.gov/pubmed/26885191
http://www.ncbi.nlm.nih.gov/pubmed/23562041
note that non-hodgkin's typically starts at the lymph nodes not at the bone marrow and still could be caused by epstein barr infecting with the estrogen receptors
http://www.ncbi.nlm.nih.gov/pubmed/22247563
Burkitt Lymphoma
Two types of Burkitt : endemic (africa & brazil) and sporatic (western countries with AIDS)
https://www.researchgate.net/publication/307157262_Differential_IgM_expression_distinguishes_two_types_of_pediatric_Burkitt_lymphoma_in_mouse_and_human
Does only EBV cause Burkitt or can HIV cause it too?
HIV and herv-k
http://journals.lww.com/jaids/Fulltext/2011/04002/183_HIV_Exposes_Major__Trafficking__in_HERV__K.76.aspx
Note that EBV was first isolated in 1964 from a Burkitt tumor of an african patient
Burkitt lymphoma and epstein barr
Primary effusion lymphoma
HHV8 and Primary effusion
http://www.bloodjournal.org/content/122/23/3712?sso-checked=true
HHV8 and Primary effusion
http://www.bloodjournal.org/content/122/23/3712?sso-checked=true
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