anterior cingulate cortex, hoarding, cortisol, spirochetes, cataracts, and depression

This post is analyzing the areas of overlap of cortisol.  It is unclear how spirochetes cause the high cortisol involved.

Recently it was made clear that OCD is not the same as emotional hoarding. If we remove the OCD and look just at the type of hoarding where the patient has the inability to give up an object no matter how illogical..this could be a distinct disorder with a distinct infection.

Area of the brain changed in a hoarder
http://www.medicalnewstoday.com/articles/248862.php
http://blogs.scientificamerican.com/observations/scans-of-hoarders-brains-reveal-why-they-never-de-clutter/

This area of the brain is responsible for the cortisol awakening response.

Serotonin 4 receptor and the cortisol awakening response
http://www.ncbi.nlm.nih.gov/pubmed/26894483

Morning awakening and the burst of cortisol
http://www.ncbi.nlm.nih.gov/pubmed/20026350

cortisol awakening and depression
http://www.ncbi.nlm.nih.gov/pubmed/25999722

High rates of panic attacks with Hoarding
http://www.ncbi.nlm.nih.gov/pubmed/24854164

Panic attacks and cortisol
http://www.ncbi.nlm.nih.gov/pubmed/10698825

Anxiety disorder and cortisol
http://www.ncbi.nlm.nih.gov/pubmed/26934635

High rates of depression and anxiety with hoarding.
http://www.ncbi.nlm.nih.gov/pubmed/25732668
http://www.ncbi.nlm.nih.gov/pubmed/23505992

high rates of depression with borrelia burgdorferi infection
https://www.ncbi.nlm.nih.gov/pubmed/12194228

So I am going to start with a "reach" looking at spirochete infections as the possible cause of high cortisol concentrations and see how many areas of overlap I can find.

ten most depressed states: more spirochetes?
http://www.health.com/health/gallery/0,,20483493,00.html/view-all

Could spirochetes cause this? There are 2 spirochetes I am going to focus on : the Borrelia which is carried by ticks and then Leptospira which is carried by dogs.

spirochete review paper
http://www1.biogema.de/WEK/312-Margulis-final.pdf

The quorum, which is the chemical communication of an infection, can interfere with the host's body. What is the quorum of spirochetes and can it explain the cortisol issue.

Borrelia's quorum: Lux...does epinephrine exist too?
http://www.ncbi.nlm.nih.gov/pubmed/12941391
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128172/

Borrelia's quorum: c-di-GMP 
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002133
this is not made very long but in the transition
 c-di-GMP appears to govern a catabolic switch in B. burgdorferi and plays a vital role in the tick part of the spirochetal enzootic cycle. It is not need to infect mammals but just ticks

e.coli and salmonella use both lux and epinephrine as quorums..are spirochetes similar?
do spirochetes use epinephrine? or because we see such high levels of cortisol are they making or stimulating that? Can infections make cortisone?

http://www.nytimes.com/1995/02/15/us/personal-health-when-lyme-invades-the-brain-and-spinal-system.html

Borreliosis in children
http://www.ncbi.nlm.nih.gov/pubmed/13130169

adults with borreliosis
http://www.ncbi.nlm.nih.gov/pubmed/12225315

 facial palsy with both

acute mycocarditis and borreliosis
http://www.ncbi.nlm.nih.gov/pubmed/1535149
http://www.ncbi.nlm.nih.gov/pubmed/15810500
http://www.ncbi.nlm.nih.gov/pubmed/7726189

increased hair cortisol before acute mycocarditis
http://www.ncbi.nlm.nih.gov/pubmed/20812871

lyme and the mind
http://www.mentalhealthandillness.com/Articles/LymeDiseaseAndCognitiveImpairments.htm

Lyme and depression...the serotonin receptors...not depressed rather emotionally dumb
http://www.examiner.com/article/the-difference-between-depression-and-lyme-depression

phobias, anxiety and cortisol
http://www.webmd.com/anxiety-panic/news/20110328/cortisol-may-help-reduce-some-phobias

cortisol and the brain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795004/

This doctor claims depression medicine causes cataracts but what if cortisone caused both the depression and the cataracts
http://www.secondopinionnewsletter.com/Health-Alert-Archive/View-Archive/1729/The-overlooked-link-between-depression-and-cataracts.htm

Lyme and cataracts
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049946/

Leptospira is a spirochete carried by dogs which can be caught by people.

cortisone causes cleft palate
http://dev.biologists.org/content/develop/5/2/201.full.pdf

Leptospira and clotting
http://www.ncbi.nlm.nih.gov/m/pubmed/20002620/

Do the bacteria secrete something that induces cortisol or do they secrete cortisol themselves?  how does cushing syndrome fit in here?

Looking at other endotoxin bacterias they have noticed that salmonella seems to have a relationship with cortisol. They proliferate with cortisol and levels tend to go up during infection.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256119/