Acute disseminated encephalomyelitis is an autoimmune inflammatory disease of the brain and spinal cord.
Autoimmune Cross-targeting hypothesis: 2 simultaneous infections on one target triggers autoimmunity. One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.
zika and acute disseminated encephalomyelitis
http://www.telegraph.co.uk/news/2016/04/10/now-scientists-find-zika-linked-brain-disorder-in-adults/
http://www.aol.com/article/2016/04/10/scientists-find-new-zika-linked-brain-disorder-in-adults/21341521/
The question is: do these patients have strep infections or have they just recovered from strep infections?
Other flaviviruses behave similarly.
dengue and acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pubmed/24250170
http://www.ncbi.nlm.nih.gov/pubmed/12111572
http://www.ncbi.nlm.nih.gov/pubmed/17568897
west nile, meningitis/ acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747452/ (and strep)
http://www.ncbi.nlm.nih.gov/pubmed/21612601
http://www.ncbi.nlm.nih.gov/pubmed/16447753
http://www.ncbi.nlm.nih.gov/pubmed/15647737
strep and acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pubmed/11706964
http://www.ncbi.nlm.nih.gov/pubmed/11891098
http://www.ncbi.nlm.nih.gov/pubmed/10751252
http://pandasnetwork.org/SwedoSnider2003.pdf
pandas following acute disseminated encephalomyelitis
http://pandasnetwork.org/first-case-report-of-pans-published-in-pediatrics/
http://www.ncbi.nlm.nih.gov/pubmed/23142103
Summary of Zika virus complictions
Zika and campylobacteria at peripheral nerves could cause Guillian Barre
Zika and strep at the spinal cord and brain could cause acute disseminated encephalomyelitis/pandas
Zika and mycobacteria at substantia nigra could cause a form of parkinson's disease
Zika and Benzene in the bone marrow could cause leukemia.
Seems logical that this Zika viruse could cross-target with strep and trigger the acute disseminated encephalomyelitis with pandas syndrome following.
Only with Zika if it is using the ACTH (Melanocortin2 receptors) the inflammation area might be greater than the other melanocortin receptor using flaviviruses.
Further if we look at these other diseases we find that a parkinson's disease drug has been found to be active against flaviviruses and could be useful against zika.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/
Autoimmune Cross-targeting hypothesis: 2 simultaneous infections on one target triggers autoimmunity. One infection is on the outside of the target cell and one infection is on the inside of the target. The partners of the infection can vary but the inside and outside paradigm is what triggers the autoimmune response that results in the development of autoimmune disease.
zika and acute disseminated encephalomyelitis
http://www.telegraph.co.uk/news/2016/04/10/now-scientists-find-zika-linked-brain-disorder-in-adults/
http://www.aol.com/article/2016/04/10/scientists-find-new-zika-linked-brain-disorder-in-adults/21341521/
The question is: do these patients have strep infections or have they just recovered from strep infections?
Other flaviviruses behave similarly.
dengue and acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pubmed/24250170
http://www.ncbi.nlm.nih.gov/pubmed/12111572
http://www.ncbi.nlm.nih.gov/pubmed/17568897
west nile, meningitis/ acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747452/ (and strep)
http://www.ncbi.nlm.nih.gov/pubmed/21612601
http://www.ncbi.nlm.nih.gov/pubmed/16447753
http://www.ncbi.nlm.nih.gov/pubmed/15647737
strep and acute disseminated encephalomyelitis
http://www.ncbi.nlm.nih.gov/pubmed/11706964
http://www.ncbi.nlm.nih.gov/pubmed/11891098
http://www.ncbi.nlm.nih.gov/pubmed/10751252
http://pandasnetwork.org/SwedoSnider2003.pdf
pandas following acute disseminated encephalomyelitis
http://pandasnetwork.org/first-case-report-of-pans-published-in-pediatrics/
http://www.ncbi.nlm.nih.gov/pubmed/23142103
Summary of Zika virus complictions
Zika and campylobacteria at peripheral nerves could cause Guillian Barre
Zika and strep at the spinal cord and brain could cause acute disseminated encephalomyelitis/pandas
Zika and mycobacteria at substantia nigra could cause a form of parkinson's disease
Zika and Benzene in the bone marrow could cause leukemia.
Seems logical that this Zika viruse could cross-target with strep and trigger the acute disseminated encephalomyelitis with pandas syndrome following.
Only with Zika if it is using the ACTH (Melanocortin2 receptors) the inflammation area might be greater than the other melanocortin receptor using flaviviruses.
Further if we look at these other diseases we find that a parkinson's disease drug has been found to be active against flaviviruses and could be useful against zika.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/
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