Drug reaction with Eosinophila systemic syndrome and uric acid

Strong and sometimes fatal reactions to drugs involving Eosinophils appear to be caused by a state of high Uric acid.  This condition can result through infections releasing lactic acid which inhibits the secretion of uric acid or from viral infections damaging the kidneys which causes then a build up of uric acid.  It is this state of high uric acid that stimulates T helper 2 cells to increase Eosinophils.  Normally damaged tissues release uric acid as a signal to T helper 2 cells who then promote the Eosinophils but....when uric acid is artificially high...Eosinphils are out of control.


DRESS
Drug reaction with Eosinophila systemic syndrome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718748/

Staph and DRESS
http://www.ncbi.nlm.nih.gov/pubmed/17053739

Clindamycin induced DRESS during staph infection
http://www.ncbi.nlm.nih.gov/pubmed/23165860

note that Allopurinol is a treatment for gout
Gout I connected to Staph
http://angelabiggs.blogspot.com/2016/03/staph-uric-acid-and-gout.html
allopurinol is one of the drugs triggering DRESS

ziprasidone: schizophrenia drug (t.gondii)
Dapsone: leprosy/mycobacteria or t.gondii infection
Allopurinol: gout drug (staph ? or t.gondii?)
sulfonamide : antibiotic
minocycline: mycobacteria and MARSA (staph)
lamotrigine: seizure and schizophrenia drug
phenytoin: seizure medication

Do these drugs cause a reaction from infections? Do these drugs stimulate the infections to make lactic acid?

Is the uric acid from high lactic acid ? staph makes lactic acid and so does t.gondii
Lactic acid prevents the secretion of uric acid

t.gondii makes lactic acid
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000188

schizophrenia and high uric acid levels
http://www.ncbi.nlm.nih.gov/pubmed/22926590

uric acid and chronic kidney disease
http://www.ncbi.nlm.nih.gov/pubmed/20683957
http://www.ncbi.nlm.nih.gov/pubmed/23543594

hyperurcemia is high blood uric acid

kidneys are suppose to secrete uric acid into urine

Eosinophils and the response to uric acid produced by damaged tissues (it's their job)
http://www.ncbi.nlm.nih.gov/pubmed/20483787

the high uric acid could be what triggers eosinophils (through T helper 2?)

What about the viral causes of DRESS? A virus doesn't make lactic acid.

HHV6 or epstein barr?  Do they damage the kidney's mitochondrias and cause a similar syndrome by elevating uric acid?  Is the condition to be feared high Uric acid?

Dysphagia,which is difficulty swallowing, is often an early symptom of DRESS and is often associated with gout
http://www.eblue.org/article/S0190-9622(13)01021-9/abstract
http://www.ehealthme.com/cs/gout/dysphagia

Uric Acid and the Th2 of the immune system
http://www.jimmunol.org/content/192/9/4032.full
http://www.sciencedirect.com/science/article/pii/S1074761311001221

wells syndrome is eosinophilic cellulitis
http://emedicine.medscape.com/article/1124844-overview

cyclosporine treats wells syndrome possibly by acting on T helper cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057600/pdf/11641541.pdf

Cyclosporine is known to resolve DRESS syndrome
http://www.ncbi.nlm.nih.gov/pubmed/16114793
http://www.ncbi.nlm.nih.gov/pubmed/20110143

However one does not have to have an infection to have gout and  DRESS. One could merely be an alcoholic.

Note that the relationship between gout and alcohol have been known since Henry the VIII. Alcohol especially beer's purines raises the lactic acid levels of the body.  When lactic acid levels are high uric acid is not secreted and causes gout.  Alcohol itself is secreted instead of uric acid by the kidney when levels are high.