Tuesday, September 6, 2016

Postural orthostatic tachycardia, Reoviruses, and adrenergic receptors...is there a connection?

Postural orthostatic tachycardia, Reoviruses, and adrenergic receptors...is there a connection?

This blog has been looking at autoimmune diseases. It is unclear if hyperadrenic POTS is  an autoimmune disease. This is the pattern so far with reoviruses looking like culprits of the disease not so much as triggers of an autoimmune reaction.

 Disease cluster : POTS, Ehler-danlos syndrome, mast cell activation
http://www.jacionline.org/article/S0091-6749(14)02927-3/abstract

(hyperadrenic POTS)

reoviruses are found in mast cell tumors in dogs
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073555

mast cell syndrome in people..90% is cutaneous  (reovirus involved here too?)
http://www.medscape.com/viewarticle/450039_2

Autoimmune diseases with POTS

1 in 4 ( 25% ) of POTS patients had ANA (antinuclear antibodies)
1 in 9 POTS patients had Hashimoto's

Reoviruses create ANA
Fungal infections can have reoviruses in them

Hashimoto's, I had hypothesized, as connected to fungal infections

avian reovirus affects joints (hock)of chickens
http://www.ncbi.nlm.nih.gov/pubmed/2163092
http://www.ncbi.nlm.nih.gov/pubmed/10935283

Ehlers-Danlos syndrome (hyperflexibility)
https://en.wikipedia.org/wiki/Ehlers%E2%80%93Danlos_syndrome

(EDS that is sporadic not genetic...but they are disorders of collagen)

EDS and local anaesthetics (the added epinephrine triggers pots but not the vascular constriction that would hold the anaesthetics locally)
http://www.reluctantcontortionist.co.uk/eds/eds-and-anaesthetics/

pots and EDS
http://www.ncbi.nlm.nih.gov/pubmed/25156902
http://www.ncbi.nlm.nih.gov/pubmed/24685354
http://www.ncbi.nlm.nih.gov/pubmed/26198889

a genetic form of POTS is the norephinephrine transport defect
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600095/

Autoantibodies to adrenergic receptors in POTS syndrome
http://www.ncbi.nlm.nih.gov/pubmed/24572257

reovirus can bind adrenergic receptors
http://jvi.asm.org/content/64/2/639.full.pdf
http://www.ncbi.nlm.nih.gov/pubmed/2831655

Raynaud's and increased epinephrine / norephinephrine
http://circres.ahajournals.org/content/7/6/821

Raynaud's and pots
http://www.ncbi.nlm.nih.gov/pubmed/26610893
http://www.ncbi.nlm.nih.gov/pubmed/26242228
http://www.ncbi.nlm.nih.gov/pubmed/20723911

Vaccines and pots: we use eggs in the development of vaccines..do some of the eggs have avian reoviruses? the percent would be small?  (I am for Vaccines. )

flu and pots
http://www.uscfc.uscourts.gov/sites/default/files/opinions/MORAN.HIBBARD052511.pdf
http://forums.phoenixrising.me/index.php?threads/our-difficulties-with-current-flu-vaccine-and-dysautonomia.6713/

Gardasil and POTS connection
http://www.ncbi.nlm.nih.gov/pubmed/25882168

detection of reovirus in bird flu vaccine
http://www.ncbi.nlm.nih.gov/pubmed/15620400

POTS after chicken pox infection (zoster)....and anti-virals?
https://www.researchgate.net/publication/290480129_P-B34_Postural_tachycardia_syndrome_POTS_after_Varicella_Zoster_virus_infection_chicken_pox

Any thoughts?

celiac and rotavirus
http://www.ncbi.nlm.nih.gov/pubmed/17032199

I had hypothesized celiac as autoimmune cross-targeting of e.coli or sutterella like infections marking the outside and a virus like rotavirus marking the inside of the intestinal cells.

autonomic dysfunction and celiac
http://www.ncbi.nlm.nih.gov/pubmed/25554987
http://www.ncbi.nlm.nih.gov/pubmed/25962148
http://www.ncbi.nlm.nih.gov/pubmed/20940666

Is this the celiac group that was triggered by rotaviruses?

raynaud's and scleroderma
http://www.medscape.com/viewarticle/493381

aspergillus and scleroderma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116216/

remember aspergillus can have reovirus infections

ANA is in 12% of scleroderma patients
http://www.ncbi.nlm.nih.gov/pubmed/25580285

older post of aspergillus, scleroderma, raynauds,
http://angelabiggs.blogspot.com/2016/07/pernio-chilbain-raynoids-sle.html

norepinephrine and collagen???
http://www.ncbi.nlm.nih.gov/pubmed/19575289

scleroderma is the build up of collagen in skin cells (collagen was also the issue in EDS)

not exactly sure what this means yet

the norepinephrine transporter gene is the suspect for "panic disorder"
http://www.ncbi.nlm.nih.gov/pubmed/21416264
http://www.ncbi.nlm.nih.gov/pubmed/15722184

anxiety and panic in lupus
http://www.ncbi.nlm.nih.gov/pubmed/26748551
http://www.ncbi.nlm.nih.gov/pubmed/21078764
http://www.ncbi.nlm.nih.gov/pubmed/19500858

Panic disorder vs anxiety and EDS
http://www.edhs.info/about1-cs05

joint pain and ANA: to determine SLE in children:
http://www.ncbi.nlm.nih.gov/pubmed/26114367
http://www.ncbi.nlm.nih.gov/pubmed/15245579

Note that it also inhibits B and T cells and is currently used in immunosuppression
https://en.wikipedia.org/wiki/Mycophenolic_acid
and Mycophenolate mofetil is being used in some lupus and scleroderma cases

How does the immune system normally fight reoviruses? with NO

Nitric oxide increases during rotavirus infections
http://www.ncbi.nlm.nih.gov/pubmed/16721855
http://www.ncbi.nlm.nih.gov/pubmed/16004984  NO inhibits reoviruses too!!!

 what a strange thought: could laughing gas stop panic attacks?







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