Postural orthostatic tachycardia syndrome (POTS) is it reoviruses or autoimmune cross-targeting? autonomic dysfunction and e.coli?

Is Postural orthostatic tachycardia an autoimmune disease or is it the result of a reovirus alone?

POTS and autoimmunity
http://www.ncbi.nlm.nih.gov/pubmed/24572257

what is reovirus?
https://en.wikipedia.org/wiki/Reoviridae

Reoviruses are non enveloped viruses which cause gastro intestinal issues.

reoviruses can contaminate egg shells
http://www.thepoultrysite.com/publications/6/diseases-of-poultry/200/reovirus-infections/

reovirus can bind adrenergic receptors
http://jvi.asm.org/content/64/2/639.full.pdf
http://www.ncbi.nlm.nih.gov/pubmed/2831655

actually binds the antagonist site of the receptor (blocks it?)
http://jvi.asm.org/content/64/2/639.full.pdf

reoviruses, isoprel, and beta-adrenergic receptors...no shared binding???
http://europepmc.org/abstract/med/2831655

isoprel activates beta adrenergic receptors

Autoantibodies to adrenergic receptors in POTS syndrome
http://www.ncbi.nlm.nih.gov/pubmed/24572257

Gardasil and POTS connection
http://www.ncbi.nlm.nih.gov/pubmed/25882168

Is it the HPV trigger cross-targeting with a larger infection or is it contamination of the vaccine by a reovirus?

Vaccines are made using eggs creating the possibility of egg shell contamination hence the warning of egg allergy and vaccines

Could contamination of the Gardasil vaccine by reoviruses cause the development of POTS?

The safety of Gardasil vaccines and the link to Pots might disappear when the method of vaccine development changes if it is the reovirus
http://allergynotes.blogspot.com/2010/03/next-generation-of-flu-vaccines-cell.html

I say this because I believe in vaccination

note that some cases of POTS have been connected to gastrointestinal issues which could be the group of POTS not connected to vaccines

gastro complaints with POTS patients
http://www.ncbi.nlm.nih.gov/pubmed/24068608

also note that reoviruses can infect fungus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC368758/

could this explain the overlap of Sjogren's and Hashimoto's with POTS if they are caused by fungal infections?

or is it the fact most yeasts have something like reoviruses in them?
http://www.nature.com/nature/journal/v268/n5619/abs/268464a0.html

or is it the fungus cross-targeting with the HPV?

the reason I changed my mind that POTS was autoimmune, I am leaning toward the reovirus, was my discover that some of the  flu vaccines can cause it....HPV and the flu are very different viruses

http://forums.phoenixrising.me/index.php?threads/our-difficulties-with-current-flu-vaccine-and-dysautonomia.6713/

detection of reovirus in bird flu vaccine
http://www.ncbi.nlm.nih.gov/pubmed/15620400

The adrenergic system involves the use of the neurotransmitters epinephrine and norepinephrine while cholinergic uses acetylcholine

Note that there are 3 types of POTS: neuropathic (idiopathic nerve disease), hyperadrenergic (high nor-epinephrine levels),  secondary (caused by circulation issues like diabetes)

genetic POTS is the nor-ephinephrine type
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600095/

since reoviruses bind adrenergic receptors do they trigger POTS?

Or is it autoimmune cross-targeting which would indicate damage to the heart is occurring. Is this true? does the immune system attack the heart? or is it merely a reovirus infection

Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target triggers autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

At this point it seems that the heart is not being attacked by the immune system but rather that somehow the adrenergic receptors are over stimulated. Either by reoviruses or the antibodies seeking the binding of them?

Note that salmonella and e.coli use epinephrine /norepinephrine as their quorums (communication signals between the bacteria
https://www.readbyqxmd.com/read/16487745/quorum-sensing-in-escherichia-coli-and-salmonella

Celiac patients tent to have bladder infections histories and bladder infections are commonly e.coli infections

Could e.coli not only trigger the autoimmune cross-targeting of celiac disease but be the cause of the autonomic dysfunction?

autonomic dysfunction and celiac
http://www.ncbi.nlm.nih.gov/pubmed/25554987
http://www.ncbi.nlm.nih.gov/pubmed/25962148
http://www.ncbi.nlm.nih.gov/pubmed/20940666

note that this is different from the autoimmune attack of the peripheral nerves which is like guillian barre

Campylobacteria/sutterella could probably trigger the celiac and guillian barre but not POTS.

POTS after chicken pox infection (zoster)....and anti-virals?
https://www.researchgate.net/publication/290480129_P-B34_Postural_tachycardia_syndrome_POTS_after_Varicella_Zoster_virus_infection_chicken_pox

anti-viral ribavirin and reovirus
http://www.sciencedirect.com/science/article/pii/0042682289904133

ribavirin and zoster
http://www.ncbi.nlm.nih.gov/pubmed/3298116

ribavirin
https://books.google.com/books?id=aoeBKqsswM8C&pg=PA70&lpg=PA70&dq=ribavirin+yeast&source=bl&ots=WQ6c3tcA0z&sig=eaZrMnYwvkD6jZFO9uYqEoepnlw&hl=en&sa=X&ved=0ahUKEwjqis6T2PDOAhUUHmMKHR46BVo4ChDoAQhWMAk#v=onepage&q=ribavirin%20yeast&f=false

flu and pots
http://forums.phoenixrising.me/index.php?threads/our-difficulties-with-current-flu-vaccine-and-dysautonomia.6713/

http://www.uscfc.uscourts.gov/sites/default/files/opinions/MORAN.HIBBARD052511.pdf

if from reovirus of egg shells

avian reovirus affects joints
http://www.ncbi.nlm.nih.gov/pubmed/2163092
http://www.ncbi.nlm.nih.gov/pubmed/10935283

POTS tends to have hypermobility in joints
http://www.edhs.info/#!dysautonomia-and-edhs/clvf

http://www.dynakids.org/Documents/hypermobility.pdf

hock
http://articles.extension.org/pages/65756/hock

epinephrine is used in local anesthetics to limit bleeding (constricts local blood supply)


some people react to the epinephrine..."pots" people?