Tuesday, August 23, 2016

Enteroviruses and nicotine acetylcholine receptors..does polio and d68 use the muscarine acetylcholine receptors or the ganglion nicotine receptors? can a nicotine patch help?

These are all ideas of how to slow the d68 infection but the AFM is probably caused by autoimmune cross-targeting where it is the body's own immune system that causes the paralysis.
http://angelabiggs.blogspot.com/2018/10/is-autoimmune-triggered-paralysis.html

It is the immune system we need to stop in order to stop the paralysis. There are ideas for kids with eczema/asthma who I feel are in the high risk group of developing the autoimmune disease due to the staph infection cross-targeting with d68. 

Rabies binds the neurotoxin binding site of the nicotinic acetylcholine receptor
http://www.ncbi.nlm.nih.gov/pubmed/8887475

This neurotoxin binding site is where nicotine binds
http://www.ncbi.nlm.nih.gov/pubmed/3448605

coxsackie virus (an enterovirus) infection is blocked by nicotine
http://www.ncbi.nlm.nih.gov/pubmed/26851533
http://www.ncbi.nlm.nih.gov/pubmed/26507386
http://www.ncbi.nlm.nih.gov/pubmed/26851533

Enteroviruses might bind the same receptor family as the rabies virus.

Hypothesis:
Enveloped virus families bind specific receptor families.

Looking at the types of nicotine binding receptors:
https://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor

4 subtypes (these can be further divided)

Can we match up the enteroviruses with these receptors?

2 type the exists in the spine/ ganglion (GS) sympathetic and parasympathetic (GP)

2 types in the brain (B1 and B2)

one type exists in muscles (M)

Coxsackie appears to be using the Muscle type

non-polio enteroviruses are responsible for half of aseptic meningitis in children
http://www.ncbi.nlm.nih.gov/pubmed/17668054

Are most non- polio viruses using B1 and B2 but typically don't have access to the brain due to the blood brain barrier?

Do these viruses bind everywhere that nicotine does? Wouldn't it be strange if during enterovirus infections nicotine was given medically? or does polio and d68 bind muscarine ACH not nicotine ACH?

prozac and acetylcholine receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20039/

prozac and d68 paralysis
http://www.neurologyadvisor.com/general-neurology/prozac-enterovirus-d68-paralysis-treatment/article/403896/

Prozac, that inhibits the replication of the virus, does not seem to reverse the d68's AFM
https://www.empr.com/news/fluoxetine-enterovirus-antiviral-acute-flaccid-myelitis/article/814285/

entroviruses could also bind "neural cell adhesion molecule"
http://jvi.asm.org/content/72/9/7181.full

D68 and sialic acid immunoglobulin like dependent entry
https://www.ncbi.nlm.nih.gov/pubmed/26563423
http://www.nature.com/ncomms/2015/151113/ncomms9865/full/ncomms9865.html

anti-nACH receptors with immunoglobulin antibodies (commercially made)
http://www.ncbi.nlm.nih.gov/pubmed/20619959 

rabies virus and sialic acid binding of receptors
http://www.ncbi.nlm.nih.gov/pubmed/8004936

rabies binding the muscarine ACH
https://www.ncbi.nlm.nih.gov/pubmed/15804965

Acetylcholine receptors and sialic acid
https://www.ncbi.nlm.nih.gov/pubmed/20487973

these overlaps supports the notion that the enteroviruses use ACH receptors but which one?

sialic acid dependent entry of D68
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660200/

Enterovirus 71 infection blocked by:  heparin, polysulfated dextran sulfate, and suramin 
http://jvi.asm.org/content/87/1/611.full


estrogen and acetylcholine
file:///Users/angelabiggs/Downloads/Crosstalk_between_nicotine_and_estrogen-induced_estrogen_receptor_activation_induces_alpha9-nicotinic_acetylcholine_receptor_expression_in_human_breast_cancer_cell.pdf



1 comment:

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